全文获取类型
收费全文 | 902篇 |
免费 | 36篇 |
出版年
2022年 | 7篇 |
2021年 | 6篇 |
2020年 | 9篇 |
2019年 | 10篇 |
2018年 | 6篇 |
2016年 | 12篇 |
2015年 | 33篇 |
2014年 | 29篇 |
2013年 | 52篇 |
2012年 | 58篇 |
2011年 | 56篇 |
2010年 | 27篇 |
2009年 | 22篇 |
2008年 | 51篇 |
2007年 | 43篇 |
2006年 | 44篇 |
2005年 | 36篇 |
2004年 | 30篇 |
2003年 | 38篇 |
2002年 | 46篇 |
2001年 | 8篇 |
2000年 | 8篇 |
1999年 | 17篇 |
1998年 | 15篇 |
1997年 | 7篇 |
1996年 | 17篇 |
1995年 | 9篇 |
1994年 | 12篇 |
1993年 | 9篇 |
1992年 | 7篇 |
1991年 | 15篇 |
1990年 | 16篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 7篇 |
1986年 | 16篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 10篇 |
1979年 | 13篇 |
1978年 | 12篇 |
1977年 | 9篇 |
1975年 | 7篇 |
1974年 | 9篇 |
1973年 | 10篇 |
1972年 | 6篇 |
1968年 | 5篇 |
排序方式: 共有938条查询结果,搜索用时 296 毫秒
931.
Kjell Einar Erikstad Hanno Sandvik Tone Kristin Reiertsen Jan Ove Bustnes Hallvard Str?m 《Proceedings. Biological sciences / The Royal Society》2013,280(1769)
In long-lived species, any negative effect of pollution on adult survival may pose serious hazards to breeding populations. In this study, we measured concentrations of various organochlorines (OCs) (polychlorinated biphenyl and OC pesticides) in the blood of a large number of adult glaucous gulls (Larus hyperboreus) breeding on Bjørnøya (Bear Island) in the Norwegian Arctic, and modelled their local survival using capture–recapture analysis. Survival was negatively associated with concentrations of OCs in the blood. The effect of OCs was nonlinear and evident only among birds with the highest concentrations (the uppermost deciles of contamination). The threshold for depressed survival differed between the sexes, with females being more sensitive to contamination. For birds with lower OC concentration, survival was very high, i.e. at the upper range of survival rates reported from glaucous and other large gull species in other, presumably less contaminated populations. We propose two non-exclusive explanations. First, at some threshold of OC concentration, parents (especially males) may abandon reproduction to maximize their own survival. Second, high contamination of OC may eliminate the most sensitive individuals from the population (especially among females), inducing a strong selection towards high-quality and less sensitive phenotypes. 相似文献
932.
The ontogeny of the skeleton of the nassellarian radiolarian Amphimelissa setosa begins with the formation of three radial bars of silica; these correspond to the medial bar and spines L1 and L2 in the adult. By a precise sequence of the addition of various siliceous arcs and spines, this basic structure develops into the eucephalus. A new growth mechanism, in which existing skeletal elements serve as templates for the formation of new skeletal members, is hypothesized to explain the observed developmental patterns. The early ontogeny of nassellarian skeletons can be used to determine which skeletal features develop earliest. Among the structural characteristics used by radiolarian systematists, these conservative features are most suitable for use in interpretation of the taxonomic relationships and phylogeny of the group. 相似文献
933.
Electrical activity was recorded from single cells in the olfactorybulb when electrically stimulating the medial and lateral olfactorytract and when stimulating the olfactory epithelium with aminoacids. Bulbar units excited by stimulation of the medial olfactorytract were found in the medial and middle parts of the bulb.Neurones in the dorso-lateral part of the bulb were excitedby stimulation of lateral tract. Units inhibited by stimulationof the lateral or medial olfactory tracts had a reversed distributionwith the majority found in the medial or lateral parts of thebulb respectively. The chemicals tested induced changes in thedischarge of units mainly situated in the lateral part of thebulb. 相似文献
934.
Jose Erik Alvarez-Contino Estela Díaz-Sánchez Marina Mirchandani-Duque Jose Andrés Sánchez-Pérez Miguel A. Barbancho Alexander López-Salas Natalia García-Casares Kjell Fuxe Dasiel O. Borroto-Escuela Manuel Narváez 《Journal of cellular physiology》2023,238(2):459-474
Dysregulation of adult hippocampal neurogenesis is linked to major depressive disorder (MDD), with more than 300 million people diagnosed and worsened by the COVID-19 pandemic. Accumulating evidence for neuropeptide Y (NPY) and galanin (GAL) interaction was shown in various limbic system regions at molecular-, cellular-, and behavioral-specific levels. The purpose of the current work was to evaluate the proliferating role of GAL2 receptor (GALR2) and Y1R agonists interaction upon intranasal infusion in the ventral hippocampus. We studied their hippocampal proliferating actions using the proliferating cell nuclear antigen (PCNA) on neuroblasts or stem cells and the expression of the brain-derived neurothrophic factor (BDNF). Moreover, we studied the formation of Y1R–GALR2 heteroreceptor complexes and analyzed morphological changes in hippocampal neuronal cells. Finally, the functional outcome of the NPY and GAL interaction on the ventral hippocampus was evaluated in the forced swimming test. We demonstrated that the intranasal infusion of GALR2 and the Y1R agonists promotes neuroblasts proliferation in the dentate gyrus of the ventral hippocampus and the induction of the neurotrophic factor BDNF. These effects were mediated by the increased formation of Y1R–GALR2 heteroreceptor complexes, which may mediate the neurites outgrowth observed on neuronal hippocampal cells. Importantly, BDNF action was found necessary for the antidepressant-like effects after GALR2 and the Y1R agonists intranasal administration. Our data may suggest the translational development of new heterobivalent agonist pharmacophores acting on Y1R–GALR2 heterocomplexes in the ventral hippocampus for the novel therapy of MDD or depressive-affecting diseases. 相似文献
935.
Tormod Mørk Steinar Waage Tore Tollersrud Bjørg Kvitle Ståle Sviland 《Acta veterinaria Scandinavica》2007,49(1):23
Background
Clinical mastitis is an important disease in sheep. The objective of this work was to identify causal bacteria and study certain epidemiological and clinical features of clinical mastitis in ewes kept for meat and wool production. 相似文献936.
Jenny Tulldahl Kjell Pettersson Susan W. Andersson Lena Hulthn 《Obesity (Silver Spring, Md.)》1999,7(5):431-437
TULLDAHL, JENNY, KJELL PETTERSSON, SUSAN W. ANDERSSON, AND LENA HULTHÉN. Mode of infant feeding and achieved growth in adolescence: Early feeding patterns in relation to growth and body composition in adolescence. Obes Res. Objective: Feeding mode in infancy and differences in childhood growth have been studied in several longitudinal studies, but few studies have followed children up to adolescent age. There is evidence that formula-fed infants weigh more and are taller than their breast-fed counterparts, and indications that this difference may sustain. Research Methods and Procedures: We have studied the relations between length of breast-feeding, growth, and body composition in a group of 781 representatively chosen adolescents. Data on feeding pattern in infancy and on weight and height from birth up to 18 years were collected. We studied the relation between high body mass index (BMI) (defined as ≤85th percentile) in adolescence and length of breast-feeding. Results: Girls who were not breast-fed or breast-fed for less than 3 months had a significantly higher height curve than girls exclusively breast-fed for more then 3 months. There were tendencies towards higher values of adipose tissue measured by skinfolds in girls breast-fed for 3 months or less. Short duration of exclusive breast-feeding was associated with higher BMI (p<0. 04). In a subgroup of 194 adolescents, body composition was measured with dual energy X-ray. Both boys and girls who were exclusively breast-fed for more than 3 months were leaner and showed a trend towards lower skinfold values. Conclusion: These results are important to include in the debate about optimal feeding in infancy. Regarding breastfeeding as a standard, our results imply that formula fed infants may be at risk for overfeeding, which might lead to overweight, even up to adolescent age. 相似文献
937.
Are Kristiansen Kjell M. Vårum Hans Grasdalen 《Biochimica et Biophysica Acta (BBA)/General Subjects》1998,1425(1):137-150
This paper considers the non-productive (inhibitory) binding of chitosans to lysozyme from chicken egg white. Chitosans are linear, binary heteropolysaccharides consisting of 2-acetamido-2-deoxy-β-d-glucose (GlcNAc; A-unit) and 2-amino-2-deoxy-β-d-glucose (GlcN, D-unit). The active site cleft of lysozyme can bind six consecutive sugar residues in subsites named A–F, and specific binding of chitosan sequences to lysozyme occurs with A-units in subsite C. Chitosans with different fractions of A-units (FA) induced nearly identical changes in the 1H NMR spectrum of lysozyme upon binding, and the concentration of bound lysozyme could be determined. The data were analysed using a modified version of the McGhee and von Hippel model for binding of large ligands to one-dimensional homogeneous lattices. The average value of the dissociation constant for different sequences that may bind to lysozyme (KaveD) was estimated, as well as the number of chitosan units covered by lysozyme upon binding. KaveD decreased with increasing FA-values at pH* 3 and 4.5, while the opposite was true at pH* 5.5. Contributions from different hexamer sequences to KaveD of the chitosans were considered, and the data revealed interesting features with respect to binding of lysozyme to partially N-acetylated chitosans. The relevance of the present data with respect to understanding lysozyme degradation kinetics of chitosans is discussed. 相似文献
938.
Abstract. 1. In eclosion experiments at constant temperatures (6, 9, 12, 15, 18, 21, and 25 °C), Operophtera brumata (L.) pupae were found to respond nonlinearly to temperature, with 9 °C giving the highest developmental rate.
2. Pupal development rate decreased and mortality increased at the highest and lowest temperatures. No pupae eclosed at 6, 21, or 25 °C.
3. Exposing pupae to periods of cold did not enhance their rate of development consistently, indicating that no pupal diapause occurred. Light did not affect the length of the pupal period significantly.
4. Variation in mean developmental rates across temperatures was modelled both for data in the present study (northern Norway) and for a previously published German study (20° further south). The German population had a longer pupal period at all temperatures than the northern population (mean difference of 88 days). The difference is assumed to be genetically based, and hence an adaption to (and not a consequence of) differences in phenology between the two sites.
5. The diversity of the life cycle of O. brumata is discussed. Timing of eclosion can be explained by the selective forces of predation by birds on the one hand and mortality due to early snowfall on the other. 相似文献
2. Pupal development rate decreased and mortality increased at the highest and lowest temperatures. No pupae eclosed at 6, 21, or 25 °C.
3. Exposing pupae to periods of cold did not enhance their rate of development consistently, indicating that no pupal diapause occurred. Light did not affect the length of the pupal period significantly.
4. Variation in mean developmental rates across temperatures was modelled both for data in the present study (northern Norway) and for a previously published German study (20° further south). The German population had a longer pupal period at all temperatures than the northern population (mean difference of 88 days). The difference is assumed to be genetically based, and hence an adaption to (and not a consequence of) differences in phenology between the two sites.
5. The diversity of the life cycle of O. brumata is discussed. Timing of eclosion can be explained by the selective forces of predation by birds on the one hand and mortality due to early snowfall on the other. 相似文献