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61.
62.
Yukari Yokoyama Kotaro Otsuka Norito Kawakami Seiichiro Kobayashi Akira Ogawa Kozo Tannno Toshiyuki Onoda Yumi Yaegashi Kiyomi Sakata 《PloS one》2014,9(7)
Mental health is one of the most important issues facing disaster survivors. The purpose of this study is to determine the prevalence and correlates of mental health problems in survivors of the Great East Japan Earthquake and Tsunami at 6–11 months after the disaster. The questionnaire and notification were sent to the survivors in three municipalities in the Tohoku area of the Northern part of Honshu, Japan’s largest island, between September 2011 and February 2012. Questionnaires were sent to 12,772, 11,411, and 18,648 residents in the Yamada, Otsuchi, and Rikuzentakata municipalities, respectively. Residents were asked to bring the completed questionnaires to their health check-ups. A total of 11,124 or (26.0%) of them underwent health check-ups, and 10,198 were enrolled. We excluded 179 for whom a K6 score was missing and two who were both 17 years of age, which left 10,025 study participants (3,934 male and 6,091 female, mean age 61.0 years). K6 was used to measure mental health problems. The respondents were classified into moderate (5–12 of K6) and serious mental health problems (13+). A total of 42.6% of the respondents had moderate or serious mental health problems. Multivariate analysis showed that women were significantly associated with mental health problems. Other variables associated with mental health problems were: younger male, health complaints, severe economic status, relocations, and lack of a social network. An interaction effect of sex and economic status on severe mental health problems was statistically significant. Our findings suggest that mental health problems were prevalent in survivors of the Great East Japan Earthquake and Tsunami. For men and women, health complaints, severe economic status, relocations, and lack of social network may be important risk factors of poor mental health. For men, interventions focusing on economic support may be particularly useful in reducing mental health problems after the disaster. 相似文献
63.
In this study, we present findings that suggest that PI3K-C2α, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process of FcεRI-triggered degranulation. RBL-2H3 cells were transfected with shRNA targeting PI3K-C2α. The knockdown impaired the FcεRI-induced release of a lysosome enzyme, β-hexosaminidase, without affecting the intracellular Ca2+ mobilization. The release of mRFP-tagged neuropeptide-Y, a reporter for the regulated exocytosis, was also decreased in the PI3K-C2α-deficient cells. The release was increased significantly by the expression of the siRNA-resistant version of PI3K-C2α. In wild-type cells, FcεRI stimulation induced the formation of large vesicles, which were associated with CD63, a marker protein of secretory granules. On the vesicles, the existence of PI3K-C2α and PtdIns(3,4)P2 was observed. These results indicated that PI3K-C2α and its product PtdIns(3,4)P2 may play roles in the secretory process. 相似文献
64.
Hiroyuki Ichikawa Ruji Terayama Tomoichiro Yamaai David M. Jacobowitz Feng Qiu Mengging Xiang Tomosada Sugimoto 《Cellular and molecular neurobiology》2009,29(5):691-698
Immunohistochemistry for neuron-specific nuclear protein (NeuN), caspase-3, calcitonin gene-related peptide (CGRP), and calcium-binding
proteins was performed on the trigeminal ganglion (TG) in wild type and Brn-3a knockout mice at embryonic days 12.5–16.5 (E12.5–E16.5). In Brn-3a knockout mice, the number of NeuN-immunoreactive (ir) neuron profiles increased at E14.5 (40.0% increase) and decreased at
E16.5 (28.3% reduction) compared to wild type mice. Caspase-3-ir neuron profiles were abundant in the TG of wild type mice
at E12.5–E16.5. However, the loss of Brn-3a decreased the number of caspase-3-ir neuron profiles at E12.5 (69.7% reduction) and E14.5 (51.7% reduction). At E16.5, the
distribution of caspase-3-ir neuron profiles was barely affected by the deficiency. CGRP-ir neuron profiles were observed
in the TG of wild type mice but not knockout mice at E12.5. At E14.5 and E16.5, CGRP-ir neuron profiles were abundant in both
wild type and knockout mice. Calbindin D-28 k (CB)-ir neuron profiles decreased in the TG of mutant mice at E12.5 compared
to wild type mice (56.4% reduction). At E14.5, however, Brn-3a deficiency transiently increased CB-ir neuron profiles (169.4% increase as compared to wild type mice). Calretinin (CR)-ir
neuron profiles could not be detected in the TG of wild type mice at E12.5–16.5. However, numerous CR-ir neuron profiles transiently
appeared in the knockout mouse at E14.5. Parvalbumin (PV)-ir neurons appeared in wild type and knockout mice at E14.5. At
this stage, the number of large (>50 μm2) PV-ir neuron profiles in knockout mice was fewer than that in wild type mice. The number and cell size of PV-ir neuron profiles
were barely affected by the deficiency at E16.5. The present study indicates that the loss of Brn-3a causes increase of TG neurons at E14.5 and decrease of TG neurons at E16.5. It is also suggested that Brn-3a deficiency affects the number and cell size of CGRP- and calcium-binding protein-containing neurons at E12.5 and E14.5. Caspase-3-dependent
cell death of CB- and CR-ir neurons may be suppressed by the deficiency at E14.5. 相似文献
65.
66.
Takushi Nagata Kiyomi Imagawa Tohru Yamada
Teruaki Mukaiyama
《Inorganica chimica acta》1994,220(1-2):283-287A novel manganese(III) complex having an optically active N, N′-ethylenebis-β-ketoimine ligand was prepared and characterized crystallographically. The manganese(III) complexes behave as effective catalysts in enantioselective epoxidation of unfunctionalized olefins by combined use of molecular oxygen, an oxidant, and pivalaldehyde, a reductant. Dihydronaphthalene derivatives were converted into the corresponding optically active epoxides with good to high enantioselectivities. 相似文献
67.
Green-leaved and red-leaved Perilla plants (short-day plants)cultured aseptically on diluted modified White's medium or onfull strength White's medium (W) containing reduced concentrationsof nitrogen sources, initiated flower buds under continuouslight (2,0002,200 lux fluorescent lamps) at 2426?C.The addition of sucrose to the medium promoted flower formation;the optimum concentration was 2% in 1/10?W medium. The plantscultured on unfertilized vermiculite also developed flower budsreadily, unlike those on fertilized vermiculite. High-intensity light (8,000 lux fluorescent lamps) given duringthe first 30 days of culture promoted flowering. This effectwas also produced to a lesser degree by the addition of sucroseto the medium, instead. On the other hand, high-intensity lightgiven during the second 30 days or throughout the culture periodinhibited flowering, irrespective of the presence of sucrosein the medium. (Received February 4, 1982; Accepted June 14, 1982) 相似文献
68.
Chi-Man Leong Wei-Huang Tsai Mamoru Terayama Shiuh-Feng Shiao Chung-Chi Lin 《Journal of Asia》2018,21(1):124-129
A trap-jaw ant Anochetus lanyuensis sp. nov., belonging to the graeffei species group Brown, 1978, is described on the basis of worker and gyne castes from Orchid Island (Lanyu), Taiwan. A. lanyuensis sp. nov. is easily distinguishable from the other species in the graeffei species group by the large size of its eye, longitudinal striae on the pronotal disc, and concave dorsal margin of the petiolar node in the frontal view. 相似文献
69.
Thalita Macedo Araújo Magalhães Teixeira Souza Raphael Hermano Santos Diniz Celina Kiyomi Yamakawa Lauren Bergmann Soares Jaciane Lutz Lenczak Juliana Velasco de Castro Oliveira Gustavo Henrique Goldman Edilene Alves Barbosa Anna Clara Silva Campos Ieso Miranda Castro Rogelio Lopes Brandão 《Antonie van Leeuwenhoek》2018,111(10):1749-1766
This work was performed to verify the potential of yeast strains isolated from cachaça distilleries for two specific biotechnological applications: beer and bioethanol production. In the beer production, the strains were tested for characteristics required in brewery practices, such as: capacity to ferment maltose and maltotriose, ability to grow at lowest temperatures, low H2S production, and flocculation profile. Among the strains tested, two of them showed appropriate characteristics to produce two different beer styles: lager and ale. Moreover, both strains were tested for cachaça production and the results confirmed the capacity of these strains to improve the quality of cachaça. In the bioethanol production, the fermentation process was performed similarly to that used by bioethanol industries: recycling of yeast biomass in the fermentative process with sulfuric acid washings (pH 2.0). The production of ethanol, glycerol, organic acids, dry cell weight, carbohydrate consumption, and cellular viability were analyzed. One strain presented fermentative parameters similar to PE2, industrial/commercial strain, with equivalent ethanol yields and cellular viability during all fermentative cycles. This work demonstrates that cachaça distilleries seem to be an interesting environment to select new yeast strains to be used in biotechnology applications as beer and bioethanol production. 相似文献
70.
Tadayoshi Taniyama Setsuo Takai Emi Miyazaki Ryutaro Fukumura Junko Sato Yoshiro Kobayashi Tadashi Hirakawa Kevin W. Moore Kiyomi Yamada 《Human genetics》1995,95(1):99-101
The human interleukin-10 receptor (IL-10R) gene has previously been mapped to chromosome 11. Here, we have determined the precise location of the human IL-10R gene by the fluorescence in situ hybridization method, and have found that the IL-10R gene maps to chromosome 11q23.3. 相似文献