全文获取类型
收费全文 | 96篇 |
免费 | 7篇 |
出版年
2020年 | 1篇 |
2017年 | 1篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 2篇 |
2012年 | 3篇 |
2011年 | 6篇 |
2010年 | 2篇 |
2009年 | 3篇 |
2008年 | 1篇 |
2007年 | 3篇 |
2006年 | 8篇 |
2005年 | 2篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 10篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 4篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1958年 | 1篇 |
1957年 | 1篇 |
1956年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有103条查询结果,搜索用时 15 毫秒
101.
102.
Hideki Tanaka Hirotsugu Hino Shota Moriya Hiromi Kazama Masaya Miyazaki Naoharu Takano Masaki Hiramoto Kiyoaki Tsukahara Keisuke Miyazawa 《Biochemistry and Biophysics Reports》2020
Tyrosine kinase inhibitors (TKIs) induce autophagy in many types of cancer cells. We previously reported that gefitinib (GEF) and imatinib (IMA) induce autophagy in epidermal growth factor receptor (EGFR) knock-out A549 and non-BCR-ABL-expressing leukemia cell lines, respectively. This evidence suggests that TKI-induced autophagy is independent of the original target molecules. The present study compared the autophagy-inducing abilities of various TKIs, regardless of their targets, by quantitative autophagy flux assay. We established stable clones expressing the GFP-LC3-mCherry-LC3ΔG plasmid in A549, PC-9, and CAL 27 cell lines and assessed autophagy inducibility by monitoring the fluorescent ratios of GFP-LC3 to mCherry-LC3ΔG using an IncuCyte live cell imaging system during exposure to TKIs viz; GEF, osimertinib (OSI), lapatinib (LAP), lenvatinib (LEN), sorafenib (SOR), IMA, dasatinib (DAS), and tivantinib (TIV). Among these TKIs, DAS, GEF, and SOR exhibited prominent autophagy induction in A549 and PC-9 cells. In CAL 27 cells, IMA, SOR, and LEN, but not GEF, TIV, or OSI, exhibited autophagy induction. In the presence of azithromycin (AZM), which showed an inhibitory effect on autophagy flux, TKIs with prominent autophagy inducibility exhibited enhanced cytotoxicity via non-apoptotic cell death relative to effects of TKI alone. Therefore, autophagy inducibility of TKIs differed in the context of cancer cells. However, once induced, they appeared to have cytoprotective functions. Thus, blocking TKI-induced autophagy with AZM may improve the therapeutic effect of TKIs in cancer cells. 相似文献
103.
Kazuyuki Uchimura Hiroyuki Ai Kiyoaki Kuwasawa Tomoko Matsushita Makoto Kurokawa 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2006,192(2):175-185
The frontal ganglion of the silkworm (Bombyx mori) gives rise to a visceral nerve, branches of which include a pair of anterior cardiac nerves and a pair of the posterior
cardiac nerves. Forward-fill of the visceral nerve with dextran labeled with tetramethyl rhodamine shows the anterior cardiac
nerves innervate the anterior region of the dorsal vessel. Back-fill of the anterior cardiac nerves with Co2+ and Ni2+ ions and the fluorescent dye reveals that the cell bodies of two motor neurons are located in the frontal ganglion. Injection
of 5, 6-carboxyfluorescein into the cell body of an identified motor neuron shows that the neuron gives rise to an axon running
to the visceral nerve. Unitary excitatory junctional potentials (EJPs) were recorded from a myocardial cell at the anterior
end of the heart. They responded in a one-to-one manner to electrical stimuli applied to the visceral nerve, or to impulses
generated by a depolarizing current injected into the cell body. EJPs induced by stimuli at higher than 0.5 Hz showed facilitation
while those induced at higher than 2 Hz showed summation. Individual EJPs without summation, or a train of EJPs with summation,
caused acceleration in the phase of posterograde heartbeat and heart reversal from anterograde heartbeat to posterograde heartbeat.
It is likely that the innervation of the anterior region of the dorsal vessel by the motor neurons, through the anterior cardiac
nerves is responsible for the control of heartbeat in Lepidoptera, at least in part. 相似文献