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41.
Modern gene therapeutic approaches towards the treatment of malignant neoplasms are discussed. Specifically, results of the first experiments on the development of vaccines on the basis of tumor cells modified with various cytokines and activation molecules are described. We compare effectiveness of different cytokines used for modification of tumor cells are made and consider possible mechanisms of vaccine action. The reasons for impossibility of the development of effective endogenous antitumor immunity are examined. The results of comparative analysis of the Tag7 protein antitumor activity are presented. This evidence clearly shows that Tag7 is a promising agent for anticancer therapy. 相似文献
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Zarubaev VV Krivitskaia VZ Nebol'sin VE Kiselev OI 《Antibiotiki i khimioterapii͡a》2010,55(7-8):13-16
The Ingavirin antiviral properties with respect to the parainfluenza virus, as an actual human respiratory tract pathogen, were investigated by two methods, i.e. immunoenzymatic analysis and microtetrazolium test. The results showed that along with the immediate antiviral activity Ingavirin had nonspecific cytoprotective properties. While affecting the virus proteins synthesis, Ingavirin lowered the virus cytopathogenic action. The drug significantly decreased the portion of the bronchial epithelium cells killed at the stage of acute infection. 相似文献
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A. R. Kiselev A. B. Bespyatov O. M. Posnenkova V. I. Gridnev V. I. Ponomarenko M. D. Prokhorov P. Ya. Dovgalevskii 《Human physiology》2007,33(2):188-193
Synchronization parameters of 0.1-Hz rhythms isolated from the heart rate and the oscillations of the blood volume in microcirculatory vessels were studied in 12 healthy subjects and 32 patients with acute myocardial infarction. Recordings of the electrocardiogram and the pulsogram from the distal phalanx of the index finger, as well as mechanical recording of respiration with the body in a horizontal position, were performed. In patients with myocardial infarction, the recordings were performed during the first three to five days and the third week after the infarction. Synchronization was tested by plotting phase differences and calculating the total percentage of phase synchronization. Synchronization parameters of 0.1-Hz rhythms were high in healthy subjects. In patients with acute myocardial infarction, synchronization of 0.1-Hz rhythms was considerably poorer. The data obtained suggest that the studied 0.1-Hz rhythms are two independent oscillatory processes that are synchronized in healthy subjects. However, this interaction may be disturbed in cardiovascular pathologies, e.g., myocardial infarction. 相似文献
47.
Sveshnikov PG Malaĭtsev VV Kiselev VI 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2007,(6):108-117
One of the most important aspects of heat shock proteins (HSP) functioning, namely their role in reactions of innate and adaptive immunity, was reviewed in the article. Mechanisms of involvement of HSP in processing and presentation of antigens to T-lymphocytes were described. Principles of construction of prophylactic and therapeutic vaccines on the basis of HSP were set out. Assessment of range of indications for their use and possible risks related with inductive action of vaccines on the development of immunopathologic processes was a specially discussed topic. 相似文献
48.
Egorov VV Solovyov KV Grudinina NA Lebedev DV Isaev-Ivanov VV Kiselev OI Shawlovsky MM 《Protein and peptide letters》2007,14(5):471-474
Symmetrical peptide GYDTQAIVENNESTEYG (WT, Wild Type) identical to 35-51 aminoacid residues of human alpha-lactalbumin (HLA) and peptide GYDTQTVVNNNGHTDYG (ID, IDeal symmetry) homologous to beta-domain of mammalian alpha-lactalbumins can form amyloid-like fibrils in conditions required for fibrillogenesis of HLA. The latter peptide can also form fibrils in deionized water. Fibrils formed by these peptides can cause forming of HLA amyloid-like aggregates in physiological conditions. These results provide an evidence for presence of amyloidogenic determinant in beta-domain of alpha-lactalbumin. Thus, symmetry in the primary structure may play the role in fibrillogenesis of proteins. 相似文献
49.
Kiselev O. I. Vasin A. V. Shevyryova M. P. Deeva E. G. Sivak K. V. Egorov V. V. Tsvetkov V. B. Egorov A. Yu. Romanovskaya-Romanko E. A. Stepanova L. A. Komissarov A. B. Tsybalova L. M. Ignatjev G. M. 《Molecular Biology》2015,49(4):480-493
Molecular Biology - Ebola hemorrhagic fever (EHF) epidemic currently ongoing in West Africa is not the first among numerous epidemics in the continent. Yet it seems to be the worst EHF epidemic... 相似文献
50.
The genetic structure of eight Mus musculus L. populations in Primorskii krai was studied with the use of taxon-specific markers of different inheritance systems: nDNA
(RAPD), mtDNA (D-loop), and chromosomes. The results obtained demonstrate that although the compared nuclear marker characteristics
(nDNA and chromosomes) have the same basis they are not linke with each other and, moreover, are often mutually inconsistent.
Discordance in the inheritance of the marker characteristics in most of the animals studied is a result of extensive hybridization
involving two to four house mouse subspecies. To identify taxonspecific nuclear markers revealed by RAPD, some RAPD PCR products
were cloned, and their localization on chromosomes was determined. It was found that some fragments similar in size consist
of two different comigrating sequences that are localized on different chromosomes and belong to different subspecies. All
sequenced anonymous markers are localized in protein-coding genes. The functions of genes containing the marker sequences
have been established. Differences in the taxon-specific RAPD fragments are associated with changes in the structure of important
functional genes, and this can be considered as a significant genetic marker. 相似文献