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981.
Motoki Murata Reia Kosaka Kana Kurihara Shuya Yamashita 《Bioscience, biotechnology, and biochemistry》2016,80(8):1636-1640
Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy. 相似文献
982.
Kyoko Kurihara Yusuke Takahara Takushi Nomura Hiroshi Ishii Nami Iwamoto Naofumi Takahashi Makoto Inoue Akihiro Iida Hiroto Hara Tsugumine Shu Mamoru Hasegawa Chikaya Moriya Tetsuro Matano 《Microbes and infection / Institut Pasteur》2012,14(13):1169-1176
Induction of durable cellular immune responses by vaccination is an important strategy for the control of persistent pathogen infection. Viral vectors are promising vaccine tools for eliciting antigen-specific T-cell responses. Repeated vaccination may contribute to durable memory T-cell induction, but anti-vector antibodies could be an obstacle to its efficacy. We previously developed a Sendai virus (SeV) vector vaccine and showed the potential of this vector for efficient T-cell induction in macaques. Here, we examined whether repeated SeV vector vaccination with short intervals can enhance antigen-specific CD8+ T-cell responses. Four rhesus macaques possessing the MHC-I haplotype 90-120-Ia were immunized three times with intervals of three weeks. For the vaccination, we used replication-defective F-deleted SeV vectors inducing CD8+ T-cell responses specific for simian immunodeficiency virus Gag206–216 and Gag241–249, which are dominant epitopes restricted by 90-120-Ia-derived MHC-I molecules. All four animals showed higher Gag206–216-specific and Gag241–249-specific CD8+ T-cell responses after the third vaccination than those after the first vaccination, indicating enhancement of antigen-specific CD8+ T-cell responses by the second/third SeV vector vaccination even with short intervals. These results suggest that repeated SeV vector vaccination can contribute to induction of efficient and durable T-cell responses. 相似文献
983.
T Ohno K Yoshii K Kurihara 《Comparative biochemistry and physiology. A, Comparative physiology》1985,82(1):153-159
Cross adaptation experiments were carried out quantitatively with the frog olfactory system by varying concentrations of odorants in a wide range. The results obtained gave quantitative information on the difference in the receptor sites for various odorants. 相似文献
984.
In a previous study we isolated homologues of new oleanane-type triterpene
glycosides from leaves of Staurogyne merguensis Kuntze and named them
strogins. Strogins themselves have a sweet taste (sweet activity), which
diminishes in a few minutes. Subsequent application of cold water to the
mouth then elicits a sweet taste (sweetness-inducing activity). In the
present study we systematically examined the properties of the sweet and
sweetness-inducing activities of strogins. Strogins 1, 2 and 4 had both the
sweet and sweetness-inducing activities, while strogins 3 and 5 had no
activities. The sweetness- inducing activity in response to cold water
lasted for 1 h for strogin 2 and 2 h for strogins 1 and 4. The
sweetness-inducing activity was immediately diminished by application of
gamma-cyclodextrin to the mouth after strogins were held in the mouth. It
seems that the strogins were adsorbed on the gustatory receptor membranes
and eliminated by inclusion activity of gamma-cyclodextrin. The structure
of strogin resembles that of gymnemic acid, which has antisweet activity.
There was competition between strogin 1 and gymnemic acid; treatment of the
tongue with strogin 1 before application of Gymnema extract to the mouth
reduced the antisweet activity. While the sweetness-inducing activity of
curculin in response to water was suppressed by the presence of divalent
cations such as Ca2+ or Mg2+, that of strogin was not suppressed by the
divalent cations. The changes in the inactive complex between strogin and
the sweet receptor site in the adaptation state into the active complex
induced by cold stimulation were discussed.
相似文献
985.
M Kashiwayanagi M Horiuchi K Kurihara 《Comparative biochemistry and physiology. A, Comparative physiology》1991,100(2):287-292
1. Dependence of the fron olfactory bulbar responses on NaCl concentration greatly varied from odorant to odorant. The responses to odorants such as 1-carvone and isoamyl acetate were essentially unchanged by removal of NaCl, while those to odorant such as citral and beta-ionone were greatly decreased by removal of NaCl. 2. The NaCl requirement for the responses to certain odorants was greatly decreased by an increase in pH or temperature of the stimulating solution. 3. It was concluded that changes in ion permeability at the apical membranes of olfactory cells including olfactory ciliary membranes are not involved in generation of the in vivo olfactory responses to certain odorants. 相似文献
986.
Yasushi Kurihara 《International Review of Hydrobiology》1989,74(5):507-548
The role of tubificids and mud snails in the ricefield ecosystem was elucidated using their ecology as a basis for highlighting problems in the strategy of recycling between agricultural and urban activities. Tubificid oligochaetes occur in high densities in ricefields where irrigation water is polluted with sewage, high organic matter content is present in the soil and when highly toxic insecticides are not used. High tubificid densities reduce and even eliminate weeds, change the composition and density of bacteria and increase the density of zooplankton. Also they serve as a high quality source of food for fish comparable to that of insects. Conditions that promote a healthy growth of tubificids obviate or reduce the need for weedicides and high levels of inorganic fertilizers. Mud snails which thrive in ricefields have been used as an important source of protein food for humans in rural Japan. The snails can consume a sludge-reed compost mixture used as a fertilizer in ricefields. However the high heavy metal content in the sludge is accumulated by the snails which are thus unfit for human consumption. Based on these results and the known ecology of tubificids and the snails, a possible recycling system comprising sewage sludge, reeds, fish, insects and egrets using these two kinds of benthic organisms is proposed. 相似文献