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Microbiota can protect their hosts from infection. The short timescales in which microbes can evolve presents the possibility that “protective microbes” can take-over from the immune system of longer-lived hosts in the coevolutionary race against pathogens. Here, we found that coevolution between a protective bacterium (Enterococcus faecalis) and a virulent pathogen (Staphylococcus aureus) within an animal population (Caenorhabditis elegans) resulted in more disease suppression than when the protective bacterium adapted to uninfected hosts. At the same time, more protective E. faecalis populations became costlier to harbor and altered the expression of 134 host genes. Many of these genes appear to be related to the mechanism of protection, reactive oxygen species production. Crucially, more protective E. faecalis populations downregulated a key immune gene, , known to be effective against S. aureus infection. These results suggest that a microbial line of defense is favored by microbial coevolution and may cause hosts to plastically divest of their own immunity. 相似文献
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R. Ernest King 《BMJ (Clinical research ed.)》1941,1(4178):154-155
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Zonotrichia capensis australis inhabits Argentina from the northernmost limits of the Patagonian steppe south through Tierra del Fuego, and extends westward to the Pacific slope in southern Chile. At least part of the population has a north-south migration along the Andean foothills of Argentina as far north as southwestern Bolivia. The breeding range of australis is bounded on the north and northwest by subspecies of Z. capensis (chilensis, choraules , and possibly hypoleuca ) having conspicuous black lateral crown-stripes. Topotypical australis (Tierra del Fuego) have plain grey crowns, but the frequency of black nuchal markings and faint lateral crown-lines increases northward in the coastal populations. In inland populations (Andean piedmont) the frequency of black crown markings is apparently reversed, increasing southward. The size (wing-length, tarsus, bill, and probably body-weight) of australis decreases northward in both coastal and inland samples.
The nesting season of australis begins in late November and early December and extends to mid January and early February. Postnuptial moult begins from mid December to early January. Moult proceeds while the testes are apparently still functional. Postnuptial moult terminates from late January through mid March. There is no evidence in the current data of geographical trends in the chronology of nesting and postnuptial moult. The calendars appear to be about the same throughout the range of australis .
Postjuvenal moult begins about 4–5 weeks later than the onset of postnuptial moult and terminates in the latest birds in about mid March. Northward migration begins at about this time. 相似文献
The nesting season of australis begins in late November and early December and extends to mid January and early February. Postnuptial moult begins from mid December to early January. Moult proceeds while the testes are apparently still functional. Postnuptial moult terminates from late January through mid March. There is no evidence in the current data of geographical trends in the chronology of nesting and postnuptial moult. The calendars appear to be about the same throughout the range of australis .
Postjuvenal moult begins about 4–5 weeks later than the onset of postnuptial moult and terminates in the latest birds in about mid March. Northward migration begins at about this time. 相似文献
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Emily J Fleming Ivona Cetini? Clara S Chan D Whitney King David Emerson 《The ISME journal》2014,8(4):804-815
Despite over 125 years of study, the factors that dictate species dominance in neutrophilic iron-oxidizing bacterial (FeOB) communities remain unknown. In a freshwater wetland, we documented a clear ecological succession coupled with niche separation between the helical stalk-forming Gallionellales (for example, Gallionella ferruginea) and tubular sheath-forming Leptothrix ochracea. Changes in the iron-seep community were documented using microscopy and cultivation-independent methods. Quantification of Fe-oxyhydroxide morphotypes by light microscopy was coupled with species-specific fluorescent in situ hybridization (FISH) probes using a protocol that minimized background fluorescence caused by the Fe-oxyhydroxides. Together with scanning electron microscopy, these techniques all indicated that Gallionellales dominated during early spring, with L. ochracea becoming more abundant for the remainder of the year. Analysis of tagged pyrosequencing reads of the small subunit ribosomal RNA gene (SSU rRNA) collected during seasonal progression supported a clear Gallionellales to L. ochracea transition, and community structure grouped according to observed dominant FeOB forms. Axis of redundancy analysis of physicochemical parameters collected from iron mats during the season, plotted with FeOB abundance, corroborated several field and microscopy-based observations and uncovered several unanticipated relationships. On the basis of these relationships, we conclude that the ecological niche of the stalk-forming Gallionellales is in waters with low organic carbon and steep redoxclines, and the sheath-forming L. ochracea is abundant in waters that contain high concentrations of complex organic carbon, high Fe and Mn content and gentle redoxclines. Finally, these findings identify a largely unexplored relationship between FeOB and organic carbon. 相似文献
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