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111.
Hashimoto Chie Ryu Heungjin Mouri Keiko Shimizu Keiko Sakamaki Tetsuya Furuichi Takeshi 《Primates; journal of primatology》2022,63(2):109-121
Primates - The operational sex ratio (OSR) is used as a predictor for the intensity of mating competition. While many factors affect the OSR, there tends to be a high male bias in primate species... 相似文献
112.
Hoque TS Okuma E Uraji M Furuichi T Sasaki T Hoque MA Nakamura Y Murata Y 《Bioscience, biotechnology, and biochemistry》2012,76(3):617-619
Methylglyoxal (MG) is a reactive aldehyde derived by glycolysis. In Arabidopsis, MG inhibited light-induced stomatal opening in a dose-dependent manner. It significantly inhibited both inward-rectifying potassium (K(in)) channels in guard-cell protoplasts and an Arabidopsis K(in) channel, KAT1, heterologously expressed in Xenopus oocytes. Thus it appears that MG inhibition of stomatal opening involves MG inhibition of K(+) influx into guard cells. 相似文献
113.
Nakajima Y Furuichi Y Biswas KK Hashiguchi T Kawahara K Yamaji K Uchimura T Izumi Y Maruyama I 《FEBS letters》2006,580(2):613-619
Anandamide (AEA) exhibits anti-inflammatory effects. However, its role in the periodontal field remains unknown. Here, we found that gingival crevicular fluid contained a detectable level of AEA. The cannabinoid receptors CB1 and CB2 were expressed by human gingival fibroblasts (HGFs), and markedly upregulated under pathological conditions. AEA significantly reduced the production of pro-inflammatory mediators (IL-6, IL-8 and MCP-1) induced by Porphyromonas gingivalis LPS in HGFs, and this effect was attenuated by AM251 and SR144528, selective antagonists of CB1 and CB2, respectively. Moreover, AEA completely blocked LPS-triggered NF-kappaB activation, implying that AEA may regulate hyperinflammatory reactions in periodontitis. 相似文献
114.
The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons 总被引:4,自引:0,他引:4 下载免费PDF全文
Crk-associated substrate (Cas) is a tyrosine-phosphorylated docking protein that is indispensable for the regulation of the actin cytoskeletal organization and cell migration in fibroblasts. The function of Cas in neurons, however, is poorly understood. Here we report that Cas is dominantly enriched in the brain, especially the cerebellum, of postnatal mice. During cerebellar development, Cas is highly tyrosine phosphorylated and is concentrated in the neurites and growth cones of granule cells. Cas coimmunoprecipitates with Src family protein tyrosine kinases, Crk, and cell adhesion molecules and colocalizes with these proteins in granule cells. The axon extension of granule cells is inhibited by either RNA interference knockdown of Cas or overexpression of the Cas mutant lacking the YDxP motifs, which are tyrosine phosphorylated and thereby interact with Crk. These findings demonstrate that Cas acts as a key scaffold that links the proteins associated with tyrosine phosphorylation signaling pathways to the granule cell axon elongation. 相似文献
115.
Tokuyama N Emikey B Bafike B Isolumbo B Iyokango B Mulavwa MN Furuichi T 《Primates; journal of primatology》2012,53(3):215-219
This is the first report to demonstrate that a large mixed-sex party of bonobos travelled a long distance to return to the location of a snare apparently to search for a member that had been caught in it. An adult male was caught in a metallic snare in a swamp forest at Wamba, Luo Scientific Reserve, Democratic Republic of the Congo. After he escaped from the snare by breaking a sapling to which the snare was attached, other members of his party assisted him by unfastening the snare from lianas in which it was caught and licked his wound and tried to remove the snare from his fingers. In the late afternoon, they left him in the place where he was stuck in the liana and travelled to the dry forest where they usually spend the night. The next morning, they travelled back 1.8 km to revisit the location of the injured male. When they confirmed that he was no longer there, they returned to the dry forest to forage. This was unlike the usual ranging patterns of the party, suggesting that the bonobos travelled with the specific intention of searching for this injured individual who had been left behind. The incident described in this report likely occurred because bonobos usually range in a large mixed-sex party and try to maintain group cohesion as much as possible. 相似文献
116.
Miho Tsuchiya Yasuko Manabe Kenichiro Yamada Yasuro Furuichi Masahiro Hosaka Nobuharu L. Fujii 《Biochemical and biophysical research communications》2013,430(2):676-682
We evaluated the effect of chronic exercise on insulin secretion in response to high-glucose by using a perifusion method with isolated pancreatic islets from normal rats. Male Wistar rats were assigned to one of two groups: a sedentary group and a trained group. Running exercise was carried out on a treadmill for one hour per day, five days per week, for six, nine, or 12 weeks. The chronic exercise significantly enhanced the insulin secretion ability of pancreatic islets in response to the high-glucose stimulation upon nine and 12 weeks of exercise. The insulin content in the pancreas and the weight of the pancreas did not change upon nine weeks of exercise. Potassium-stimulated insulin secretion was also increased in the islets isolated from rats that trained for nine weeks compared with that in sedentary rats, suggesting that insulin secretion events downstream of membrane depolarization are involved in targets of the exercise effect. These findings suggest that chronic exercise could be a useful strategy not only for the maintenance of peripheral insulin sensitivity but also for the promotion of islet function to secrete insulin in non-diabetics. 相似文献
117.
Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant 总被引:1,自引:0,他引:1
Iwai M Tateishi Y Hattori M Mizutani A Nakamura T Futatsugi A Inoue T Furuichi T Michikawa T Mikoshiba K 《The Journal of biological chemistry》2005,280(11):10305-10317
We isolated cDNAs encoding type 2 and type 3 inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R2 and IP(3)R3, respectively) from mouse lung and found a novel alternative splicing segment, SI(m2), at 176-208 of IP(3)R2. The long form (IP(3)R2 SI(m2)(+)) was dominant, but the short form (IP(3)R2 SI(m2)(-)) was detected in all tissues examined. IP(3)R2 SI(m2)(-) has neither IP(3) binding activity nor Ca(2+) releasing activity. In addition to its reticular distribution, IP(3)R2 SI(m2)(+) is present in the form of clusters in the endoplasmic reticulum of resting COS-7 cells, and after ATP or Ca(2+) ionophore stimulation, most of the IP(3)R2 SI(m2)(+) is in clusters. IP(3)R3 is localized uniformly on the endoplasmic reticulum of resting cells and forms clusters after ATP or Ca(2+) ionophore stimulation. IP(3)R2 SI(m2)(-) does not form clusters in either resting or stimulated cells. IP(3) binding-deficient site-directed mutants of IP(3)R2 SI(m2)(+) and IP(3)R3 fail to form clusters, indicating that IP(3) binding is involved in the cluster formation by these isoforms. Coexpression of IP(3)R2 SI(m2)(-) prevents stimulus-induced IP(3)R clustering, suggesting that IP(3)R2 SI(m2)(-) functions as a negative coordinator of stimulus-induced IP(3)R clustering. Expression of IP(3)R2 SI(m2)(-) in CHO-K1 cells significantly reduced ATP-induced Ca(2+) entry, but not Ca(2+) release, suggesting that the novel splice variant of IP(3)R2 specifically influences the dynamics of the sustained phase of Ca(2+) signals. 相似文献
118.
Takeshi Furuichi 《Primates; journal of primatology》1985,26(3):219-237
Adult male association and its annual change were studied in a wild population of Japanese macaques (Macaca fuscata yakui) on Yakushima Island, Japan. Unlike many other Japanese macaque troops, adult troop males frequently maintained proximity
and exchanged grooming with one another in both the mating and non-mating seasons, and the dominance relationship rarely appeared
in such inter-male associations. The few cases of agonistic interactions occurred mostly when estrous females or food resources
were immediately concerned. Although troop males were very intolerant to newly appeared solitary males (new males) during
the mating season, close associations were formed between troop males and new males as soon as the mating season terminated.
The consort of new males and lower-ranking troop males with estrous females was frequently disturbed, but these males could
copulate no less frequently than higher-ranking males. A comparison among macaque species suggests the existence of two forms
of inter-male association: (1) the frequent association based on the symmetrical exchange of social behaviors; and (2) the
infrequent and asymmetrical association related to the dominance relationship. The form of inter-male association seems to
be influenced by whether or not males can keep close associations with females throughout the year. 相似文献
119.
120.
Miyamoto K Kodera N Umekawa H Furuichi Y Tokita M Komai T 《International journal of biological macromolecules》2002,30(3-4):205-212
Cryogel is a physical gel formed by heterophilic aggregation of extra domain A containing fibronectin [EDA(+)FN], plasma fibronectin (pFN), fibrinogen (Fbg) and heparin (Hep), which are found in high concentrations in the blood of patients suffering from rheumatoid arthritis. In this study, we clarify the specific interactions between cryogel components in terms of the affinity constant (K(A)), obtained by surface plasmon resonance (SPR). It is found that Fbg self-interactions occur at lower temperatures, and that K(A) of Fbg-Hep changes with temperature. Specifically, K(A) (2.0 x 10(8) [M(-1)]) of Fbg-Hep at 5 degrees C increases significantly from that (1.0x10(7) [M(-1)]) at 40 degrees C. K(A) of EDA(+)FN-Hep increases with temperature, by approximately 100-fold between 40 degrees C (K(A)=10(12) [M(-1)]) and 20 degrees C (K(A)=10(10) [M(-1)]). Although K(A) of the FN fragments of Hep-binding domain containing an EDA region [EDA(+)HBD(+)] and Hep increases with temperatures above 30 degrees C, K(A)s of HBD(+)-Hep and EDA(+)-Hep are not temperature-dependent. Therefore, EDA(+)HBD(+), formed as a special structure for high Hep affinity, exhibits temperature-dependent interaction with Hep. These results suggest that the main role of EDA(+)FN in cryogelation is to support the interaction with Hep. 相似文献