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101.
Patricia A. Boyd Sheila Christie Nicholas D. Hastie David J. Porteous 《Human genetics》1989,81(4):349-352
Summary Genes implicated in the development of Wilms' tumour (WT) and aniridia (AN2) have been localised to a subregion of band p13
on chromosome 11 by molecular and cytogenetic characterisation of WAGR syndrome patients carrying variable constitutional
deletions. Polymorphic markers for the region would be valuable for linkage analysis in the familial forms of both Wilms'
tumour and aniridia, as well as for studying somatic rearrangements of chromosome 11 in a variety of tumour types. Here we
describe the isolation and characterisation of three frequently polymorphic arbitrary DNA fragments that map proximal to the
AN2 and WT loci. 相似文献
102.
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104.
The Role of Mouse Adenovirus Type 1 Early Region 1A in Acute and Persistent Infections in Mice 总被引:2,自引:2,他引:0 下载免费PDF全文
Mouse adenovirus type 1 (MAV-1) early region 1A (E1A) viral mutants were used to determine the importance of this region in pathogenesis and establishment of a persistent infection in the natural host. Lethal dose analysis with adult male Swiss outbred mice revealed a significant reduction in virulence for all of the E1A mutants. During acute infections with 105 PFU of virus, an E1A null mutant, pmE109, was found in the same organs (brain, spleen, and spinal cord) and the same cell types (endothelial cells and mononuclear cells in lymphoid tissue) as wild-type virus. Another null mutant, pmE112, was detected in the same organs but in lower numbers. However, when mice were given a lower dose, 1 PFU, pmE109 and pmE112 reached none of the target organs analyzed by 14 days postinfection (p.i.). The absence of E1A did not hinder the ability of MAV-1 to establish a persistent infection. Viral nucleic acid was detected by PCR amplification or in situ hybridization in the kidneys, brains, spleens, and prefemoral lymph nodes of mice infected with wild-type or mutant virus up to 55 weeks p.i. The brain, spleen, and lymph node are recognized sites of acute viral infection but are previously unrecognized sites for MAV-1 persistence. Evidence for the potential reactivation of persistent MAV-1 infections is also presented. 相似文献
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K. N. Christie 《The Histochemical journal》1973,5(5):473-477
Synopsis The effect on the localization of succinate dehydrogenase of coating fresh and frozen-dried cryostat sections of unfixed hamster liver with celloidin was examined. It was found that the protective celloidin film not only leads to a more discrete localization of the enzyme, but is also prevents high losses of nitrogenous materials from sections into the incubation medium, a 30% loss in contrast to the 70% with fresh, non-coated sections. Further, after incubation, the morphology of the coated sections is much better than the uncoated ones. 相似文献
107.
A. B. Christie 《BMJ (Clinical research ed.)》1943,1(4279):41-42
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R. Christie Brown 《BMJ (Clinical research ed.)》1935,1(3885):1251-1255