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31.
Biophysics - The pre- and postsynaptic effects of ATP on thermal sensibility in the diaphragm of the rat have been studied. It has been found that reduction in the bath temperatute from 37 to... 相似文献
32.
Mikhailova AG Khairullin RF Demidyuk IV Gromova TY Kostrov SV Rumsh LD 《Biochemistry. Biokhimii?a》2011,76(4):480-490
Enzymatic properties of a novel oligopeptidase B from psychrotolerant gram-negative microorganism Serratia proteamaculans (PSP) were studied. The substrate specificity of PSP was analyzed using p-nitroanilide substrates, and the influence of calcium ions on the enzyme activity was studied. Hydrolysis of oligopeptides
by PSP was studied using melittin as the substrate. Optimal conditions for the PSP activity (pH and temperature) have been
established. It was found that PSP shares some properties with oligopeptidases B from other sources containing two Asp/Glu
residues in the S2 site, but it differs significantly in some characteristics. The S2 site of PSP contains only one Asp460
residue. The secondary specificity of PSP has a number of specific features: an unusual substrate inhibition by peptides with
hydrophobic residues at the P2 position, as well as the drastic influence of calcium ions on substrate characteristics of
the enzyme. It is assumed that the PSP molecule contains a large hydrophobic substrate-binding site, and significant conformational
rearrangements of the enzyme active site are induced by Ca2+ binding and by the formation of the enzyme-substrate complex. The temperature characteristics of PSP (high activity at low
temperature as well as low apparent temperature optimum (25°C)) confirm that PSP is a psychrophilic enzyme. 相似文献
33.
Maksimov I. V. Ganiev R. M. Khairullin R. M. 《Russian Journal of Plant Physiology》2002,49(2):221-224
The seedling growth and the content of endogenous phytohormones in wheat seedlings were estimated 3, 6, and 9 days after infection with the bunt pathogen (Tilletia caries) (DC.)TUL. The infection of a pathogen-susceptible species Triticum aestivum L. and a resistant species T. timopheevii Zhuk. resulted, respectively, in an increase and a decrease in the seedling growth and the IAA content as compared to the control. The cytokinin content increased in both species, and the increase in T. timopheevii was more rapid. The pathogen-induced increase in auxin content is suggested to enhance fungal invasion of plants. In the susceptible species, a high ABA concentration was retained for a longer period of time and could act as a factor of virulence. At the same time, in the resistant species, an increase in ABA content was transient and seems to trigger plant defense mechanisms. 相似文献
34.
Khairullin A. E. Grishin S. N. Teplov A. Yu. Eremeev A. A. Baltina T. V. Ziganshin A. U. 《Biophysics》2022,67(6):1007-1010
Biophysics - Identification of the pre- and postsynaptic effects of ATP is a methodological challenge. In our previous study, the role of P2 receptor signaling in synaptic transmission processes... 相似文献
35.
L. S. Karpova N. M. Popovtseva T. P. Stolyarova K. A. Stolyarov S. M. Mamadaliyev B. M. Khairullin N. T. Sandybayev Zh K. Kydyrbayev M. B. Orynbayev K. S. Ospanov B. S. Baiserkin E. U. Boibosinov 《中国病毒学》2011,26(5):306-314
The aim of the work is the comparison of the epidemiology of influenza and acute respiratory virus infections(ARVI)in the Republic of Kazakhstan with the corresponding influenza epidemic in Russia induced by influenza pandemic virus A/California/07/2009 in 2009. Data on influenza and ARVI from the Republic of Kazakhstan and Federal Center of influenza was collected and investigated over the course of several weeks from hospitalized patients with the same diagnosis among all population and in age groups on 16 territories of Kazakhstan and in 49 major cities of Russia. The epidemic in Kazakhstan resembled the Russian epidemic in terms of its abnormally early beginning,expression of monoaetiology,the spread of the epidemic into all territories and start of the epidemics among adult population. High percentage of hospitalized people and lethal outcome were registered in this epidemic. Similarity of epidemic process character in corresponding border-line territories of both countries was found out. 相似文献