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971.
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Taniyama Yukari Yamauchi Takenori Takeuchi Shouhei Kuroda Yoshiki 《Sleep and biological rhythms》2015,13(4):342-347
Sleep and Biological Rhythms - Workers with shift work schedules often experience shift work disorder (SWD). However, all shift workers do not necessarily develop SWD. The aim of this... 相似文献
974.
Michael Rowse Shihong Qiu Jun Tsao Tongmei Xian Sarah Khawaja Yohei Yamauchi Zhen Yang Guoxin Wang Ming Luo 《PloS one》2015,10(3)
New inhibitors of influenza viruses are needed to combat the potential emergence of novel human influenza viruses. We have identified a class of small molecules that inhibit replication of influenza virus at picomolar concentrations in plaque reduction assays. The compound also inhibits replication of vesicular stomatitis virus. Time of addition and dilution experiments with influenza virus indicated that an early time point of infection was blocked and that inhibitor 136 tightly bound to virions. Using fluorescently labeled influenza virus, inhibition of viral fusion to cellular membranes by blocked lipid mixing was established as the mechanism of action for this class of inhibitors. Stabilization of the neutral pH form of hemagglutinin (HA) was ruled out by trypsin digestion studies in vitro and with conformation specific HA antibodies within cells. Direct visualization of 136 treated influenza virions at pH 7.5 or acidified to pH 5.0 showed that virions remain intact and that glycoproteins become disorganized as expected when HA undergoes a conformational change. This suggests that exposure of the fusion peptide at low pH is not inhibited but lipid mixing is inhibited, a different mechanism than previously reported fusion inhibitors. We hypothesize that this new class of inhibitors intercalate into the virus envelope altering the structure of the viral envelope required for fusion to cellular membranes. 相似文献
975.
Danielle Kian César Armando Contreras Lancheros Igor Alexandre Campos Damiani Tamiris Zanforlin Olmos Fernandes Phileno Pinge-Filho Márcia Regina Machado dos Santos José Franco da Silveira Celso Vataru Nakamura Jo?o Santana da Silva Sueli Fumie Yamada-Ogatta Lucy Megumi Yamauchi 《The Korean journal of parasitology》2015,53(4):483-488
976.
Tomohiro Yamauchi Yasumasa Kuroda Takahiro Morita Hideo Shichinohe Kiyohiro Houkin Mari Dezawa Satoshi Kuroda 《PloS one》2015,10(3)
Objective
Bone marrow stromal cells (BMSCs) are heterogeneous and their therapeutic effect is pleiotropic. Multilineage-differentiating stress enduring (Muse) cells are recently identified to comprise several percentages of BMSCs, being able to differentiate into triploblastic lineages including neuronal cells and act as tissue repair cells. This study was aimed to clarify how Muse and non-Muse cells in BMSCs contribute to functional recovery after ischemic stroke.Methods
Human BMSCs were separated into stage specific embryonic antigen-3-positive Muse cells and -negative non-Muse cells. Immunodeficient mice were subjected to permanent middle cerebral artery occlusion and received transplantation of vehicle, Muse, non-Muse or BMSCs (2.5×104 cells) into the ipsilateral striatum 7 days later.Results
Motor function recovery in BMSC and non-Muse groups became apparent at 21 days after transplantation, but reached the plateau thereafter. In Muse group, functional recovery was not observed for up to 28 days post-transplantation, but became apparent at 35 days post-transplantation. On immunohistochemistry, only Muse cells were integrated into peri-infarct cortex and differentiate into Tuj-1- and NeuN-expressing cells, while negligible number of BMSCs and non-Muse cells remained in the peri-infarct area at 42 days post-transplantation.Conclusions
These findings strongly suggest that Muse cells and non-Muse cells may contribute differently to tissue regeneration and functional recovery. Muse cells may be more responsible for replacement of the lost neurons through their integration into the peri-infarct cortex and spontaneous differentiation into neuronal marker-positive cells. Non-Muse cells do not remain in the host brain and may exhibit trophic effects rather than cell replacement. 相似文献977.
978.
Successfully achieving target weight loss influences subsequent maintenance of lower weight and dropout from treatment
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980.
Yamauchi Motoo Satoh Makoto Kitahara Tadashi Ota Ichiro Strohl Kingman 《Sleep and biological rhythms》2020,18(2):77-87
Sleep and Biological Rhythms - This review will trace the elements of neurostimulation for obstructive sleep apnea and details on its implementation, efficacy and safety, immediate clinical... 相似文献