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881.
Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy 总被引:1,自引:0,他引:1
Morimoto Sachio; Yanaga Fumi; Minakami Reiko; Ohtsuki Iwao 《American journal of physiology. Cell physiology》1998,275(1):C200
Several mutationsin human cardiac troponin T (TnT) gene have been reported to causehypertrophic cardiomyopathy (HCM). To explore the effects of themutations on cardiac muscle contractile function under physiologicalconditions, human cardiac TnT mutants, Ile79Asn and Arg92Gln, as wellas wild type, were expressed in Escherichiacoli and exchanged into permeabilized rabbit cardiac muscle fibers, and Ca2+-activatedforce was determined. The freeCa2+ concentrations required fortension generation were found to be significantly lower in the mutantTnT-exchanged fibers than in the wild-type TnT-exchanged fibers,whereas no significant differences were found in tension-generatingcapability under maximal activating conditions and in cooperativity.These results suggest that a heightenedCa2+ sensitivity of cardiac musclecontraction is one of the factors to cause HCM associated with theseTnT mutations. 相似文献
882.
A primary effect of a novel H-toxin of Clostridium septicum on the hemolysis of rabbit erythrocytes was shown to be the activation of phospholipase A2 (PLA2) associated with rabbit erythrocyte membranes by 20-fold that of controls. Furthermore, the activation of PLA2 induced by the H-toxin was enhanced in the presence of NAD. The H-toxin itself had no PLA2 activity. On the contrary, the H-toxin bound to palmitic acid at a molar proportion of 1:1 and lost its hemolytic activity. The PLA2 was not activated by the H-toxin bound to palmitic acid. These results suggest that activation of the PLA2 is responsible for development of the hemolytic activity of the H-toxin. 相似文献