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211.
Limited cortisol response to ACTH stimulation has been documented in 22 to 48% of patients with paracoccidioidomycosis (PM). Different approaches to interpret the test and inadequate selection of patients preclude an accurate appraisal of the actual incidence of adrenal insufficiency in PM. Rapid cosyntropin (ACTH) stimulation tests were performed in 38 consecutive patients (9 with the localized and 29 with the disseminated form of PM) and 40 normal controls. Subnormal cortisol responses to ACTH (60 minutes post-ACTH values below 455 nmol/l, 95% confidence limits) were found in only 4 patients (14%) with disseminated PM. If a retrospective sample of 6 patients studied previously (in whom tests were indicated due to clinical suspicion of Addison's disease) were included, or if the absolute cortisol increment above baseline was used for interpretation, we would find figures closer to those previously reported (23 and 24%, respectively). These data reflect that non-systematic evaluation or selection of a substandard criterion to interpret the test overestimates the frequency of adrenocortical insufficiency in PM. 相似文献
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This paper unfolds the events, the people and the times that led up to the
founding of AChemS and fashioned its character during its early formative
years. It describes the path over which AChemS came, going from the
original assertions and denials for the need of such an organization to its
later inception and nascent development. This narration highlights such
topics as the debate over the need for AChemS, the role of National Science
Foundation in the founding of AChemS, the derivation of the Association's
name, the choice of Sarasota and the Hyatt House as the meeting site, the
generation of the programs for the early annual meetings, the adoption of
the bylaws, the process of incorporation and tax deferment, and the birth
of the Givaudan Lectureship. Most emphatically highlighted, however, is the
enthusiasm, commitment and hard work that the members of the chemosensory
research community displayed in bringing AChemS to fruition.
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Ca2+ dynamics in neuronal growth cones: regulation and changing patterns of Ca2+ entry 总被引:3,自引:0,他引:3
Digital ratio imaging of Fura-2 fluorescence was used to determine spatially resolved dynamics of Ca2+ changes in neuronal growth cones from the molluscs, Helisoma and Aplysia. Time resolution was approximately 1 s and spatial resolution a few mm depending upon the thickness of the cell region examined. Isolated growth cones of Helisoma were shown to recover from large Ca2+ loads over a time course of minutes, therefore demonstrating Ca2+ regulation mechanisms not dependent on the rest of the cell. Ca2+ changes monitored during action potential discharge showed sharply defined spatial gradients within the growth cones, probably arising from clustering of voltage-gated Ca-channels in the surface membrane. The regions of peak concentration change appeared to shift from central regions to the growth cone periphery as the growth cones matured. There was a marked difference in soma Ca2+ changes produced by action potentials depending on whether or not the soma had sprouted neurites. Neurite-free somata showed large Ca2+ changes, whereas in somata that had recently sprouted neurites there were almost no changes for similar electrical stimulation. Measurements on growth cones of N1E115 neuroblastoma cells showed static distributions of Ca2+ similar to those in the molluscan neurons. 相似文献