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51.
Beryl Royer-Bertrand Matteo Torsello Donata Rimoldi Ikram El Zaoui Katarina Cisarova Rosanna Pescini-Gobert Franck Raynaud Leonidas Zografos Ann Schalenbourg Daniel Speiser Michael Nicolas Laureen Vallat Robert Klein Serge Leyvraz Giovanni Ciriello Nicolò Riggi Alexandre P. Moulin Carlo Rivolta 《American journal of human genetics》2016,99(5):1190-1198
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Ulf Gunnar Sonesson Katarina Lorentzon Annica Andersson Ulla-Karin Barr Jan Bertilsson Elisabeth Borch Carl Brunius Margareta Emanuelsson Leif Göransson Stefan Gunnarsson Lars Hamberg Anna Hessle Karl-Ivar Kumm Åse Lundh Tim Nielsen Karin Östergren Eva Salomon Erik Sindhöj Bo Stenberg Maria Stenberg Martin Sundberg Helena Wall 《The International Journal of Life Cycle Assessment》2016,21(5):664-676
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Stofkova A Skurlova M Tybitanclova K Veselsky L Zelezna B Jurcovicova J 《Life sciences》2006,79(26):2486-2491
Leptin, a hormone regulating body weight, food intake, and metabolism, is associated with activation of immune cells and inflammation. In this study we analyzed levels of leptin, adrenocorticotropic hormone (ACTH), corticosterone, interleukin 1beta (IL-1beta), and nitric oxide (NO) production on days 10 and 22 of adjuvant arthritis (AA) in male Long Evans rats to ascertain possible relationship of leptin with its modulators during the early and late phases of chronic inflammation. The circulating leptin levels were significantly reduced already on day 10 of AA compared to controls (1.97+/-0.22 ng/ml vs. 3.08+/-0.25 ng/ml, p<0.05); on day 22 no significant further drop was observed (1.06+/-0.21 ng/ml). Leptin mRNA in epididymal fat tissue was reduced in arthritic animals compared to controls on day 22 (0.61+/-0.09 vs. 1.30+/-0.1 arbU/GAPDH (p<0.01). IL-1beta concentration in spleen was enhanced on day 10 of AA (24.55+/-4.67 pg/100 microg protein vs. 14.33+/-1.71 pg/100 microg protein; p<0.05); on day 22 it did not differ from controls. ACTH and corticosterone levels were significantly elevated only on day 22 of AA (ACTH: 306.17+/-42.22 pg/ml vs. 157.61+/-23.94 pg/ml; p<0.05; corticosterone: 5.24+/-1.38 microg/100 ml vs. 1.05+/-0.23 microg/100 ml; p<0.01). Nitrate levels were enhanced similarly on days 10 (49.86+/-1.83 microM) and 22 of AA (43.58+/-2.17 microM), compared to controls (23.42+/-1.39 microM, p<0.001). These results show that corticosterone does not stimulate leptin production during AA. The suppression of leptin may be a consequence of permanent activation of NO, IL-1beta, and of lower weight gain. Circulating leptin does not seem to play a key role in the progression of chronic arthritis. 相似文献
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Freek?Cox Eirikur?SaelandEmail author Matthijs?Baart Martin?Koldijk Jeroen?Tolboom Liesbeth?Dekking Wouter?Koudstaal Karin?L?vgren Bengtsson Jaap?Goudsmit Katarina?Rado?evi? 《Virology journal》2015,12(1):210
Background
Influenza virus infections are responsible for significant morbidity worldwide and therefore it remains a high priority to develop more broadly protective vaccines. Adjuvation of current seasonal influenza vaccines has the potential to achieve this goal.Methods
To assess the immune potentiating properties of Matrix-M?, mice were immunized with virosomal trivalent seasonal vaccine adjuvated with Matrix-M?. Serum samples were isolated to determine the hemagglutination inhibiting (HAI) antibody titers against vaccine homologous and heterologous strains. Furthermore, we assess whether adjuvation with Matrix-M? broadens the protective efficacy of the virosomal trivalent seasonal vaccine against vaccine homologous and heterologous influenza viruses.Results
Matrix-M? adjuvation enhanced HAI antibody titers and protection against vaccine homologous strains. Interestingly, Matrix-M? adjuvation also resulted in HAI antibody titers against heterologous influenza B strains, but not against the tested influenza A strains. Even though the protection against heterologous influenza A was induced by the adjuvated vaccine, in the absence of HAI titers the protection was accompanied by severe clinical scores and body weight loss. In contrast, in the presence of heterologous HAI titers full protection against the heterologous influenza B strain without any disease symptoms was obtained.Conclusion
The results of this study emphasize the promising potential of a Matrix-M?-adjuvated seasonal trivalent virosomal influenza vaccine. Adjuvation of trivalent virosomal vaccine does not only enhance homologous protection, but in addition induces protection against heterologous strains and thus provides overall more potent and broad protective immunity.58.
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Gabriel Minarik Gabriela Repiska Michaela Hyblova Emilia Nagyova Katarina Soltys Jaroslav Budis Frantisek Duris Rastislav Sysak Maria Gerykova Bujalkova Barbora Vlkova-Izrael Orsolya Biro Balint Nagy Tomas Szemes 《PloS one》2015,10(12)