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131.
132.
Katarina Nilsson Anna Flysjö Jennifer Davis Sarah Sim Nicole Unger Simon Bell 《The International Journal of Life Cycle Assessment》2010,15(9):916-926
Purpose
The goal of the study was to compare the environmental impact of butter and margarine. Altogether, seven products were studied in three European markets: UK, Germany and France. 相似文献133.
134.
Dušan Ušjak Miroslav Dinić Katarina Novović Branka Ivković Nenad Filipović Magdalena Stevanović Marina T. Milenković 《化学与生物多样性》2021,18(1):e2000786
An increasing lack of available therapeutic options against Acinetobacter baumannii urged researchers to seek alternative ways to fight this extremely resistant nosocomial pathogen. Targeting its virulence appears to be a promising strategy, as it offers considerably reduced selection of resistant mutants. In this study, we tested antibiofilm potential of four synthetic chalcone derivatives against A. baumannii. Compound that showed the greatest activity was selected for further evaluation of its antivirulence properties. Real-time PCR was used to evaluate mRNA expression of biofilm-associated virulence factor genes (ompA, bap, abaI) in treated A. baumannii strains. Also, we examined virulence properties related to the expression of these genes, such as fibronectin- and collagen-mediated adhesion, surface motility, and quorum-sensing activity. The results revealed that the expression of all tested genes is downregulated together with the reduction of adhesion and motility. The conclusion is that 2′-hydroxy-2-methoxychalcone exhibits antivirulence activity against A. baumannii by inhibiting the expression of ompA and bap genes, which is reflected in reduced biofilm formation, adhesion, and surface motility. 相似文献
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136.
Lucia Balejcikova Katarina Siposova Peter Kopcansky Ivo Safarik 《Journal of biological physics》2018,44(3):237-243
The interaction of amyloid β-peptide (Aβ) with the iron-storage protein ferritin was studied in vitro. We have shown that Aβ during fibril formation process is able to reduce Fe(III) from the ferritin core (ferrihydrite) to Fe(II). The Aβ-mediated Fe(III) reduction yielded a two-times-higher concentration of free Fe(II) than the spontaneous formation of Fe(II) by the ferritin itself. We suggest that Aβ can also act as a ferritin-specific metallochaperone-like molecule capturing Fe(III) from the ferritin ferrihydrite core. Our observation may partially explain the formation of Fe(II)-containing minerals in human brains suffering by neurodegenerative diseases. 相似文献
137.
The field of mesenchymal stromal cell (MSC) biology and clinical cellular therapy has grown exponentially over the last few decades. With discovery of multiple tissue specific sources of stromal cells, invariably being termed MSCs, and their increasing clinical application, there is a need to further delineate the true definition of a mesenchymal stromal cell and to recognise the inherit differences between cell sources; both their potential and limitations.In this review, we discuss the importance of considering every stromal cell source as an independent entity and the need to critically evaluate and appreciate the true phenotype of these cells and their safety when considering their use in novel cell therapies. 相似文献
138.
Iva Bozic Katarina Tesovic Danijela Laketa Marija Adzic Marija Jakovljevic Ivana Bjelobaba Danijela Savic Nadezda Nedeljkovic Sanja Pekovic Irena Lavrnja 《Neurochemical research》2018,43(5):1020-1034
Kv1.3 is a voltage gated potassium channel that has been implicated in pathophysiology of multiple sclerosis (MS). In the present study we investigated temporal and cellular expression pattern of this channel in the lumbar part of spinal cords of animals with experimental autoimmune encephalomyelitis (EAE), animal model of MS. EAE was actively induced in female Dark Agouti rats. Expression of Kv1.3 was analyzed at different time points of disease progression, at the onset, peak and end of EAE. We here show that Kv1.3 increased by several folds at the peak of EAE at both gene and protein level. Double immunofluorescence analyses demonstrated localization of Kv1.3 on activated microglia, macrophages, and reactive astrocytes around inflammatory lesions. In vitro experiments showed that pharmacological block of Kv1.3 in activated astrocytes suppresses the expression of proinflammatory mediators, suggesting a role of this channel in inflammation. Our results support the hypothesis that Kv1.3 may be a therapeutic target of interest for MS and add astrocytes to the list of cells whose activation would be suppressed by inhibiting Kv1.3 in inflammatory conditions. 相似文献
139.
Deborah Hemming Dan Yakir Per Ambus Mika Aurela Cathy Besson Kevin Black Nina Buchmann Regis Burlett Alessandro Cescatti Robert Clement Patrick Gross Andr Granier Thomas Grünwald Katarina Havrankova Dalibor Janous Ivan A. Janssens Alexander Knohl Barbara K
stner Andrew Kowalski Tuomas Laurila Catarina Mata Barbara Marcolla Giorgio Matteucci John Moncrieff Eddy J. Moors Bruce Osborne Joo Santos Pereira Mari Pihlatie Kim Pilegaard Francesca Ponti Zuzana Rosova Federica Rossi Andrea Scartazza Timo Vesala 《Global Change Biology》2005,11(7):1065-1093
We present carbon stable isotope, δ13C, results from air and organic matter samples collected during 98 individual field campaigns across a network of Carboeuroflux forest sites in 2001 (14 sites) and 2002 (16 sites). Using these data, we tested the hypothesis that δ13C values derived from large‐scale atmospheric measurements and models, which are routinely used to partition carbon fluxes between land and ocean, and potentially between respiration and photosynthesis on land, are consistent with directly measured ecosystem‐scale δ13C values. In this framework, we also tested the potential of δ13C in canopy air and plant organic matter to record regional‐scale ecophysiological patterns. Our network estimates for the mean δ13C of ecosystem respired CO2 and the related ‘discrimination’ of ecosystem respiration, δer and Δer, respectively, were ?25.6±1.9‰ and 17.8 ±2.0‰ in 2001 and ?26.6±1.5‰ and 19.0±1.6‰ in 2002. The results were in close agreement with δ13C values derived from regional‐scale atmospheric measurement programs for 2001, but less so in 2002, which had an unusual precipitation pattern. This suggests that regional‐scale atmospheric sampling programs generally capture ecosystem δ13C signals over Europe, but may be limited in capturing some of the interannual variations. In 2001, but less so in 2002, there were discernable longitudinal and seasonal trends in δer. From west to east, across the network, there was a general enrichment in 13C (~3‰ and ~1‰ for the 2 years, respectively) consistent with increasing Gorczynski continentality index for warmer and drier conditions. In 2001 only, seasonal 13C enrichment between July and September, followed by depletion in November (from about ?26.0‰ to ?24.5‰ to ?30.0‰), was also observed. In 2001, July and August δer values across the network were significantly related to average daytime vapor pressure deficit (VPD), relative humidity (RH), and, to a lesser degree, air temperature (Ta), but not significantly with monthly average precipitation (Pm). In contrast, in 2002 (a much wetter peak season), δer was significantly related with Ta, but not significantly with VPD and RH. The important role of plant physiological processes on δer in 2001 was emphasized by a relatively rapid turnover (between 1 and 6 days) of assimilated carbon inferred from time‐lag analyses of δer vs. meteorological parameters. However, this was not evident in 2002. These analyses also noted corresponding diurnal cycles of δer and meteorological parameters in 2001, indicating a rapid transmission of daytime meteorology, via physiological responses, to the δer signal during this season. Organic matter δ13C results showed progressive 13C enrichment from leaves, through stems and roots to soil organic matter, which may be explained by 13C fractionation during respiration. This enrichment was species dependent and was prominent in angiosperms but not in gymnosperms. δ13C values of organic matter of any of the plant components did not well represent short‐term δer values during the seasonal cycle, and could not be used to partition ecosystem respiration into autotrophic and heterotrophic components. 相似文献
140.
Ulf Gunnar Sonesson Katarina Lorentzon Annica Andersson Ulla-Karin Barr Jan Bertilsson Elisabeth Borch Carl Brunius Margareta Emanuelsson Leif Göransson Stefan Gunnarsson Lars Hamberg Anna Hessle Karl-Ivar Kumm Åse Lundh Tim Nielsen Karin Östergren Eva Salomon Erik Sindhöj Bo Stenberg Maria Stenberg Martin Sundberg Helena Wall 《The International Journal of Life Cycle Assessment》2016,21(5):664-676