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排序方式: 共有388条查询结果,搜索用时 15 毫秒
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Cav-1 participates in the development of diabetic neuropathy pain through the TLR4 signaling pathway
Gai-Li Jia MD Qi Huang BD Yan-Nan Cao BD Ci-Shan Xie BD Yu-Jing Shen BD Jia-Li Chen BD Jia-Hui Lu BD Mao-Biao Zhang BD Jun Li PhD Yuan-Xiang Tao PhD Hong Cao MD 《Journal of cellular physiology》2020,235(3):2060-2070
This study aims to determine whether caveolin-1 (Cav-1) participates in the process of diabetic neuropathic pain by directly regulating the expression of toll-like receptor 4 (TLR4) and the subsequent phosphorylation of N-methyl-D-aspartate receptor 2B subunit (NR2B) in the spinal cord. Male Sprague-Dawley rats (120–150 g) were continuously fed with high-fat and high-sugar diet for 8 weeks, and received a single low-dose of intraperitoneal streptozocin injection in preparation for the type-II diabetes model. Then, these rats were divided into five groups according to the level of blood glucose, and the mechanical withdrawal threshold and thermal withdrawal latency values. The pain thresholds were measured at 3, 7, and 14 days after animal grouping. Then, eight rats were randomly chosen from each group and killed. Lumbar segments 4–6 of the spinal cord were removed for western blot analysis and immunofluorescence assay. Cav-1 was persistently upregulated in the spinal cord after diabetic neuropathic pain in rats. The downregulation of Cav-1 through the subcutaneous injection of Cav-1 inhibitor daidzein ameliorated the pain hypersensitivity and TLR4 expression in the spinal cord in diabetic neuropathic pain (DNP) rats. Furthermore, it was found that Cav-1 directly bound with TLR4, and the subsequent phosphorylation of NR2B in the spinal cord contributed to the modulation of DNP. These findings suggest that Cav-1 plays a vital role in DNP processing at least in part by directly regulating the expression of TLR4, and through the subsequent phosphorylation of NR2B in the spinal cord. 相似文献
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The effect of combined pulsed wave low‐level laser therapy and mesenchymal stem cell‐conditioned medium on the healing of an infected wound with methicillin‐resistant Staphylococcal aureus in diabetic rats 下载免费PDF全文
Reza Kouhkheil MSc Mohammadjavad Fridoni PhD Abbas Piryaei PhD Soudabeh Taheri Alireza S. Chirani Iraj J. Anarkooli PhD Reza Nejatbakhsh PhD Sasha Shafikhani PhD Lucia A. Schuger MD Vijaya B. Reddy MD MBA Seyed Kamran Ghoreishi PhD Reza Jalalifirouzkouhi Sufan Chien MD Mohammad Bayat PhD 《Journal of cellular biochemistry》2018,119(7):5788-5797
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Masaki Inoue MD Yoshiaki Tanaka Nagatoshi Sugita Masato Yamasaki Tadashi Yamanaka Junnosuke Minagawa Karo Nakamuro Toshiro Tani Yoshio Okudaira Tuguhiro Karita Katsumi Takayama Tatsuo Ide Osamu Tanizawa 《Biotherapy》1993,6(1):13-18
The effect of immunotherapy using sizofiran (SPG) on the prognosis of patients with ovarian cancers was prospectively studied in a total of 68 patients, who were randomly assigned to either a cisplatin, adriamycin and cyclophosphamide (PAC) therapy group or a PAC plus SPG combination therapy group.The survival rate was significantly higher in patients with stage Ic, II or III cancers treated with the PAC plus SPG combination, compared with the patients treated with PAC alone. In the SPG-receiving patients with stage Ic or more advanced cancers who were treated with four cycles or more of PAC, the outcome was improved (Cox-Mantel, p=0.074; generalized Kruskal-Wallis, p=0.032). Similar improvement was also observed in the patients with non-serous adenocarcinomas (Cox-Mantel, p-0.076; generalized Krukal-Wallis, p=0.045). No side effects attributable to SPG were recorded.The present results suggest that the use of SPG in combination with long-term chemotherapy improves the postoperative prognosis in ovarian cancer patients.Abbreviations SPG
sizofiran 相似文献
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Elizabeth Knyihár-Csillik P. Rakic Prof. B. Csillik MD PhD ScD 《Cell and tissue research》1987,247(3):599-604
Summary The effect of sciatic nerve transection on its centrally located terminals in the spinal cord was analyzed by electron microscopy in adult rhesus monkeys one and three months following lesion. Although the peripheral and intermediate portions of the dorsal roots, where the axons are enveloped by Schwann cells were normal, their central portion and their terminals in the substantia gelatinosa were remarkably altered. Transganglionic degenerative atrophy (TDA) is characterized by three distinct types of electronmicroscopic alterations. The first type exhibits a conspicuous electron density of the terminal and pre-terminal axoplasm. Importantly, shrinkage replaces fragmentation and glial engulfement of the terminal seen in the course of Wallerian degeneration. The second type is characterized by the disappearance of synaptic vesicles from the terminals. The third type of TDA consists of intricate labyrinthine structures, composed of flattened profiles of axonal, dendritic and glial elements. The complex and diverse cellular changes that occur in the upper dorsal horn following peripheral nerve injury may provide the structural basis of plasticity of the primary nociceptive system. 相似文献