全文获取类型
收费全文 | 165篇 |
免费 | 16篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 8篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 3篇 |
2015年 | 13篇 |
2014年 | 11篇 |
2013年 | 13篇 |
2012年 | 12篇 |
2011年 | 15篇 |
2010年 | 11篇 |
2009年 | 6篇 |
2008年 | 8篇 |
2007年 | 14篇 |
2006年 | 11篇 |
2005年 | 6篇 |
2004年 | 10篇 |
2003年 | 7篇 |
2002年 | 5篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
排序方式: 共有181条查询结果,搜索用时 15 毫秒
131.
Marc Haber Claude Doumet-Serhal Christiana Scheib Yali Xue Petr Danecek Massimo Mezzavilla Sonia Youhanna Rui Martiniano Javier Prado-Martinez Michał Szpak Elizabeth Matisoo-Smith Holger Schutkowski Richard Mikulski Pierre Zalloua Toomas Kivisild Chris Tyler-Smith 《American journal of human genetics》2018,102(2):331
132.
133.
Marco Rosario Capodiferro Bethany Aram Alessandro Raveane Nicola Rambaldi Migliore Giulia Colombo Linda Ongaro Javier Rivera Tomás Mendizábal Iosvany Hernández-Mora Maribel Tribaldos Ugo Alessandro Perego Hongjie Li Christiana Lyn Scheib Alessandra Modi Alberto Gòmez-Carballa Viola Grugni Gianluca Lombardo Garrett Hellenthal Alessandro Achilli 《Cell》2021,184(7):1706-1723.e24
- Download : Download high-res image (162KB)
- Download : Download full-size image
134.
135.
136.
Patrick Olbermann Christine Josenhans Yoshan Moodley Markus Uhr Christiana Stamer Marc Vauterin Sebastian Suerbaum Mark Achtman Bodo Linz 《PLoS genetics》2010,6(8)
The Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI–carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes in H. pylori show considerable genetic diversity; but the diversity of virulence factors such as the cagPAI, which transports the bacterial oncogene CagA into host cells, has not been systematically investigated. Here we compared the complete cagPAI sequences for 38 representative isolates from all known H. pylori biogeographic populations. Their gene content and gene order were highly conserved. The phylogeny of most cagPAI genes was similar to that of housekeeping genes, indicating that the cagPAI was probably acquired only once by H. pylori, and its genetic diversity reflects the isolation by distance that has shaped this bacterial species since modern humans migrated out of Africa. Most isolates induced IL-8 release in gastric epithelial cells, indicating that the function of the Cag secretion system has been conserved despite some genetic rearrangements. More than one third of cagPAI genes, in particular those encoding cell-surface exposed proteins, showed signatures of diversifying (Darwinian) selection at more than 5% of codons. Several unknown gene products predicted to be under Darwinian selection are also likely to be secreted proteins (e.g. HP0522, HP0535). One of these, HP0535, is predicted to code for either a new secreted candidate effector protein or a protein which interacts with CagA because it contains two genetic lineages, similar to cagA. Our study provides a resource that can guide future research on the biological roles and host interactions of cagPAI proteins, including several whose function is still unknown. 相似文献
137.
138.
Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study 总被引:8,自引:3,他引:5
下载免费PDF全文
![点击此处可从《Applied microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Susanne Mueller Katiana Saunier Christiana Hanisch Elisabeth Norin Livia Alm Tore Midtvedt Alberto Cresci Stefania Silvi Carla Orpianesi Maria Cristina Verdenelli Thomas Clavel Corinna Koebnick Hans-Joachim Franz Zunft Joël Dor Michael Blaut 《Applied microbiology》2006,72(2):1027-1033
A cross-sectional study on intestinal microbiota composition was performed on 230 healthy subjects at four European locations in France, Germany, Italy, and Sweden. The study participants were assigned to two age groups: 20 to 50 years (mean age, 35 years; n = 85) and >60 years (mean age, 75 years; n = 145). A set of 14 group- and species-specific 16S rRNA-targeted oligonucleotide probes was applied to the analysis of fecal samples by fluorescence in situ hybridization coupled with flow cytometry. Marked country-age interactions were observed for the German and Italian study groups. These interactions were inverse for the predominant bacterial groups Eubacterium rectale-Clostridium coccoides and Bacteroides-Prevotella. Differences between European populations were observed for the Bifidobacterium group only. Proportions of bifidobacteria were two- to threefold higher in the Italian study population than in any other study group, and this effect was independent of age. Higher proportions of enterobacteria were found in all elderly volunteers independent of the location. Gender effects were observed for the Bacteroides-Prevotella group, with higher levels in males than in females. In summary, age-related differences in the microbiota makeup were detected but differed between the study populations from the four countries, each showing a characteristic colonization pattern. 相似文献
139.
Mueller S Saunier K Hanisch C Norin E Alm L Midtvedt T Cresci A Silvi S Orpianesi C Verdenelli MC Clavel T Koebnick C Zunft HJ Doré J Blaut M 《Applied and environmental microbiology》2006,72(2):1027-1033
A cross-sectional study on intestinal microbiota composition was performed on 230 healthy subjects at four European locations in France, Germany, Italy, and Sweden. The study participants were assigned to two age groups: 20 to 50 years (mean age, 35 years; n = 85) and >60 years (mean age, 75 years; n = 145). A set of 14 group- and species-specific 16S rRNA-targeted oligonucleotide probes was applied to the analysis of fecal samples by fluorescence in situ hybridization coupled with flow cytometry. Marked country-age interactions were observed for the German and Italian study groups. These interactions were inverse for the predominant bacterial groups Eubacterium rectale-Clostridium coccoides and Bacteroides-Prevotella. Differences between European populations were observed for the Bifidobacterium group only. Proportions of bifidobacteria were two- to threefold higher in the Italian study population than in any other study group, and this effect was independent of age. Higher proportions of enterobacteria were found in all elderly volunteers independent of the location. Gender effects were observed for the Bacteroides-Prevotella group, with higher levels in males than in females. In summary, age-related differences in the microbiota makeup were detected but differed between the study populations from the four countries, each showing a characteristic colonization pattern. 相似文献
140.
Diminished production of monocyte proinflammatory cytokines during human immunodeficiency virus viremia is mediated by type I interferons 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)