全文获取类型
收费全文 | 513篇 |
免费 | 26篇 |
专业分类
539篇 |
出版年
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 9篇 |
2017年 | 8篇 |
2016年 | 14篇 |
2015年 | 6篇 |
2014年 | 14篇 |
2013年 | 19篇 |
2012年 | 18篇 |
2011年 | 24篇 |
2010年 | 18篇 |
2009年 | 17篇 |
2008年 | 32篇 |
2007年 | 26篇 |
2006年 | 27篇 |
2005年 | 28篇 |
2004年 | 27篇 |
2003年 | 24篇 |
2002年 | 22篇 |
2001年 | 16篇 |
2000年 | 12篇 |
1999年 | 19篇 |
1995年 | 2篇 |
1992年 | 20篇 |
1991年 | 12篇 |
1990年 | 15篇 |
1989年 | 9篇 |
1988年 | 10篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1981年 | 4篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1925年 | 1篇 |
排序方式: 共有539条查询结果,搜索用时 15 毫秒
21.
22.
E. K. Karpova I. Yu. Rauschenbach E. V. Burdina N. E. Gruntenko 《Doklady. Biochemistry and biophysics》2016,469(1):253-256
It is shown for the first time that the insulin receptor substrate gene chico controls the functioning of the systems of metabolism of dopamine and juvenile hormone in Drosophila melanogaster females under normal conditions and in thermal stress. 相似文献
23.
Zakharova LA Khegai II Sharova NP Melnikova VI Karpova YD Astakhova TM Popova NA Ivanova LN 《Cellular immunology》2011,(2):385-391
Dynamics of the expression of MHC class I, immune proteasomes and proteasome regulators 19S, PA28, total proteasome pool and proteasome chymotrypsin-like activity in Walker 256 tumor after implantation into Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis was studied. The tumor growth and regression in Brattleboro rats were accompanied by changes in the proteasome subunit level unlike the tumor growth in WAG rats with normal expression of arginine-vasopressin gene. In the tumor implanted into Brattleboro rats the immune proteasome level was maximal between days 14 and 17, when the tumor underwent regression. Conversely, the expression of proteasome regulators tended to decrease during this period. Immune proteasomes are known to produce antigen epitopes for MHC class I to be presented to CD8+ T lymphocytes. Enhanced expression of immune proteasomes coincided with the recovery of MHC class I expression, suggesting the efficient presentation of tumor antigens in Brattleboro rats. 相似文献
24.
A comprehensive interdisciplinary study of the cerebral mechanisms of readiness for speech was performed based on a complete neuropsychological examination according to A.R. Luria with qualification and quantification of the detected symptoms and electrophysiological data by an original method of recording and localization of the potentials synchronized with the preparation for speaking. The data on stutterers were compared with those on normal subjects and showed that stuttering is not an isolated (purely peripheral) speech disorder but is a component of a syndrome consisting of specific mnestic, neurodynamic, and motor defects that reflect dysfunction of postfrontal and median structures of the brain (functional blocks I and III according to Luria). Differences between normal and stuttering subjects in the potential related to readiness for speech were associated with the activity of deep median structures (the pons and brainstem), right subcortical nuclei, the right frontal cortex, and the left mediotemporal cortex.Translated from Fiziologiya Cheloveka, Vol. 31, No. 2, 2005, pp. 13–17.Original Russian Text Copyright © 2005 by Vartanov, Glozman, Kiselnikov, Karpova. 相似文献
25.
S N Vladimirov G T Babkina A G Venijaminova O I Gimautdinova M A Zenkova G G Karpova 《Biochimica et biophysica acta》1990,1048(2-3):245-256
Using derivatives of oligoribonucleotides bearing an active group at the 5'- or 3'-end, the affinity modification of Escherichia coli ribosomes has been investigated in model complexes imitating various steps of initiation and elongation with a different extent of approximation to the real protein-synthesizing system. The protein environment of the ribosome decoding site is determined. The S3, S4, S9, L2, L7/L12 proteins belong to the 5'-region of the decoding site, and the S5, S7, S9, L1, L16 proteins to the 3'-region. In the process of translation the template moves along the external side of the 30 S subunit, from the L1 ridge to the L7/L12 stalk. The structural arrangement of the decoding site or its nearest environment depends on the functional state of ribosomes in the process of translation. 相似文献
26.
Correction: Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus
Daniela C Dieterich Anna Karpova Marina Mikhaylova Irina Zdobnova Imbritt K?nig Marco Landwehr Martin Kreutz Karl-Heinz Smalla Karin Richter Peter Landgraf Carsten Reissner Tobias M Boeckers Werner Zuschratter Christina Spilker Constanze I Seidenbecher Craig C Garner Eckart D Gundelfinger Michael R Kreutz 《PLoS biology》2009,7(1)
27.
28.
Three-dimensional imaging by deconvolution microscopy 总被引:26,自引:0,他引:26
Deconvolution is a computational method used to reduce out-of-focus fluorescence in three-dimensional (3D) microscope images. It can be applied in principle to any type of microscope image but has most often been used to improve images from conventional fluorescence microscopes. Compared to other forms of 3D light microscopy, like confocal microscopy, the advantage of deconvolution microscopy is that it can be accomplished at very low light levels, thus enabling multiple focal-plane imaging of light-sensitive living specimens over long time periods. Here we discuss the principles of deconvolution microscopy, describe different computational approaches for deconvolution, and discuss interpretation of deconvolved images with a particular emphasis on what artifacts may arise. 相似文献
29.
30.