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851.
Jayanta K. Ray Izhar Sami Gandhi K. Kar Bidhan C. Roy Nitosh K. Brahma 《Bioorganic & medicinal chemistry》1994,2(12):1417-1421
Some novel furogamma lactams have been synthesised by one step condensation of arylaminomalonates with substituted furyl acryloyl chlorides. The annulation of substituted monocyclic gammalactams followed by cyclization produced novel tricyclic furogamma lactams. Some of these furogammalactams are found to exhibit Gram-positive and Gram-negative antibacterial activity at very high concentrations. 相似文献
852.
TORBJÖRN EBENHARD 《Biological journal of the Linnean Society. Linnean Society of London》1991,42(1-2):105-121
In metapopulation dynamics turnover of populations in isolated patches may be frequent. Regional survival of a species in such a system with frequent extinctions hinges on its colonization ability. Colonization is more than just dispersal; when a propagule reaches a new patch it faces higher extinction probabilities than does an established population. Extinction models as well as empirical data suggest that a large propagule with a potential for rapid increase in a varying environment, or with a low mortality rate in an environment perceived as constant, has a higher probability of successful colonization. Large variation in population size when it is still small increases the risk of failure. Factors introducing such variation are demographic stochasticity and environmental variation. It is hard to single out demographic traits that ensure good colonizing ability, since colonization can be achieved in many different ways, but generalists and species with self-fertilization seem to be superior. 相似文献
853.
854.
TORBJÖRN NILSSON 《Ecological Entomology》1997,22(1):82-89
1. Data from a 4-year mark–recapture study of the fungivorous tenebrionid beetle Bolitophagus reticulatus at a locality in central Sweden and a trapping study of the species elsewhere in the same region are used to describe the survival and habitat preferences of the species.
2. The adult beetle was found to survive for up to three winters. A minimum estimate of the yearly survival rate was 0.20.
3. The beetle was found to occur preferentially on tree trunks that were either standing or lying but only touching the ground along a minor part of their length; that were relatively thick; and that carried many Fomes fomentarius sporocarps. In contrast to previous information for this species, the beetle was found to use living sporocarps to a large extent, and not only dead ones.
4. An experiment with beetles given a choice between living and dead fungus tissue indicated that pairs of one male and one female beetle preferred living fungus while single beetles preferred dead fungus. 相似文献
2. The adult beetle was found to survive for up to three winters. A minimum estimate of the yearly survival rate was 0.20.
3. The beetle was found to occur preferentially on tree trunks that were either standing or lying but only touching the ground along a minor part of their length; that were relatively thick; and that carried many Fomes fomentarius sporocarps. In contrast to previous information for this species, the beetle was found to use living sporocarps to a large extent, and not only dead ones.
4. An experiment with beetles given a choice between living and dead fungus tissue indicated that pairs of one male and one female beetle preferred living fungus while single beetles preferred dead fungus. 相似文献
855.
856.
The synechococcal metallothionein locus smt consists of two divergent genes: smtA coding for the metallothionein SmtA, and smtB coding for the trans-acting regulator SmtB. The latter binds at two inverted repeats, designated S1/S2 and S3/S4, in the overlapping promoter/operator sites between the two genes. We have determined the binding stoichiometries to the entire operator/promoter DNA and to the separate S1/S2 and S3/S4 half-operator oligonucleotides using sedimentation equilibrium and sedimentation velocity measurements. The full promoter/operator DNA binds two SmtB dimers. The hydrodynamic behavior of this complex supports a compact nucleoprotein structure. Each separate S1/S2 and S3/S4 operator sequence also binds two dimers. An equal molar mixture of separate S1/S2 and S3/S4 operator sequences, in excess SmtB, forms a S1/S2-SmtB:SmtB-S3/S4 bridge complex. Combining these results with previously published binding interference data, which showed consecutive S1/S2 and S3/S4 SmtB occupancy on the operator/promoter DNA, we have developed a model for the establishment of the repression complex that appears to involve significant DNA compaction, presumably DNA bending, stabilized by SmtB-SmtB bridge interactions. DNase I footprinting titrations also showed consecutive S1/S2 and S3/S4 SmtB occupancy. The footprints expand considerably in the presence of Zn2+. Hence, SmtB remains bound to the operator sites when Zn2+ ions are present. This result is further supported by gel retardation assay. Failure of the metal ions to dissociate SmtB from the DNA points to a hitherto unknown function of SmtB in the regulation of the smt locus. 相似文献
857.
Toxic effects of diazepam (DZ), chlordiazepoxide (CDZ) and nitrazepam (NZ) on the spermatozoa of mice have been studied at the end of 1, 3, 4, 6, 8 and 12 weeks after 15 days repeated treatment with a daily oral dose of 0.5 mg. Different types of abnormalities involving both shape and size of the sperm head were noticed. Qualitatively NZ produced the maximum number of abnormal types. The incidences of abnormal sperm heads were significantly high in all the test weeks in the NZ series, at weeks 1 and 6 after DZ treatment, and at weeks 3, 4 and 6 after CDZ treatment. All three drugs produced maximum effects at week 6. The varying effects induced by the three benzodiazepines seem to be due to their differential pharmacokinetics. 相似文献
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