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Hiromi Mutsuura Kenji Kanbara Mikihiko Fukunaga Kazumi Yamamoto Ikumi Ban Kana Kitamura Yoshihide Nakai 《Applied psychophysiology and biofeedback》2009,34(4):291-298
Patients presenting with functional somatic syndrome (FSS) are common, and the symptoms are persistent and difficult to treat
for doctors and costly for society. The aim of this study was to clarify the common pathophysiology of FSS, especially the
relationship between hypothalamic-pituitary-adrenal (HPA) axis function and psychological characteristics of patients with
FSS. The subjects were 45 patients with FSS and 29 healthy controls. Salivary free cortisol was measured in the morning, and
psychological tests examining depression, anxiety and quality of life (QOL) were performed on the same day. In patients with
FSS, depressive scores showed a significant negative correlation with salivary free cortisol in the morning, although in healthy
controls, cortisol showed a significant positive correlation with depressive scores. In addition, the correlation between
other psychological test scores and cortisol secretion in patients with FSS contrasted with that of controls. The relationship
between cortisol and depression, anxiety or QOL, suggests that the HPA axis of patients with FSS is dysfunctional and does
not function properly when patients with FSS are under stress. This dysfunction may explain the pathology of medically unexplained
persistent symptoms of patients with FSS. 相似文献
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Divergent synthesis of kinase inhibitor derivatives,leading to discovery of selective Gck inhibitors
Takanori Matsumaru Makoto Inai Kana Ishigami Toshiki Iwamatsu Hiroshi Maita Satoko Otsuguro Takao Nomura Akira Matsuda Satoshi Ichikawa Masahiro Sakaitani Satoshi Shuto Katsumi Maenaka Toshiyuki Kan 《Bioorganic & medicinal chemistry letters》2017,27(10):2144-2147
We accomplished divergent synthesis of potent kinase inhibitor BAY 61-3606 (1) and 27 derivatives via conjugation of imidazo[1,2-c]pyrimidine and indole ring compounds with aromatic (including pyridine) derivatives by means of palladium-catalyzed cross-coupling reaction. Spleen tyrosine kinase (Syk) and germinal center kinase (Gck, MAP4K2) inhibition assays showed that some of the synthesized compounds were selective Gck inhibitors. 相似文献
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Motoki Murata Reia Kosaka Kana Kurihara Shuya Yamashita 《Bioscience, biotechnology, and biochemistry》2016,80(8):1636-1640
Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy. 相似文献