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Sekhar Kalva Madhana Kota Vamsee Raja Reddy T. Papi Rao K. V. Reddy Attipalli Ramachandra 《Photosynthesis research》2021,150(1-3):21-40
Photosynthesis Research - The contemporary global agriculture is beset with serious threats from diverse eco-environmental conditions causing decreases in crop yields by?~?15%. These... 相似文献
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Buchanan JL Newcomb JR Carney DP Chaffee SC Chai L Cupples R Epstein LF Gallant P Gu Y Harmange JC Hodge K Houk BE Huang X Jona J Joseph S Jun HT Kumar R Li C Lu J Menges T Morrison MJ Novak PM van der Plas S Radinsky R Rose PE Sawant S Sun JR Surapaneni S Turci SM Xu K Yanez E Zhao H Zhu X 《Bioorganic & medicinal chemistry letters》2011,21(8):2394-2399
The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, we report the synthesis, structure-activity relationships (SAR), X-ray cocrystal structure and in vivo tumor study results for a series of 2,4-bis-arylamino-1,3-pyrimidines. 相似文献
177.
Nallar SC Lin L Srivastava V Gade P Hofmann ER Ahmed H Reddy SP Kalvakolanu DV 《PloS one》2011,6(9):e24082
We have recently isolated novel IFN-inducible gene, Gene associated with Retinoid-Interferon-induced Mortality-1 (GRIM-1), using a genetic technique. Moderate ectopic expression of GRIM-1 caused growth inhibition and sensitized cells to retinoic acid (RA)/IFN-induced cell death while high expression caused apoptosis. GRIM-1 depletion, using RNAi, conferred a growth advantage. Three protein isoforms (1α, 1β and 1γ) with identical C-termini are produced from GRIM-1 mRNA. We show that GRIM-1 isoforms interact with NAF1 and DKC1, two essential proteins required for box H/ACA sno/sca RNP biogenesis and suppresses box H/ACA RNA levels in mammalian cells by delocalizing NAF1. Suppression of these small RNAs manifests as inefficient rRNA maturation and growth suppression. Interestingly, yeast Shq1p also caused growth suppression in mammalian cells. Consistent with its growth-suppressive property, GRIM-1 expression is lost in a number of human primary prostate tumors. Our observations support a recent study that GRIM-1 might act as a co-tumor suppressor in the prostate. 相似文献
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Kondapalli Venkata Gowri Chandra Sekhar Vajja Samabasiva Rao Mutyala Murali Krishna 《Journal of enzyme inhibition and medicinal chemistry》2013,28(3):871-875
A series of N-{2-[4-(substituted)piperazin-1-yl]-2-oxoethyl}acetamides were synthesized as prospective novel atypical antipsychotic agents. Microwave irradiation of acetyl glycine (I) with substituted piperazines in the presence of DCC in DMF for about 3-5 min gave the titled compounds (P:1-7). All the synthesized compounds were screened for their in vivo pharmacological activity in Swiss albino mice. D2 antagonism studies were performed using the climbing mouse assay model and 5-HT2A antagonism studies were performed using quipazine induced head twitches in mice. Among the synthesized compounds P4 was found to be the most active compound. 相似文献
179.
Mitali Bhattacharjee Rakesh Sharma Renu Goel Lavanya Balakrishnan Santosh Renuse Jayshree Advani Shantal Tankala Gupta Renu Verma Sneha M Pinto Nirujogi Raja Sekhar Bipin Nair T S Keshava Prasad H C Harsha Ramesh Jois Subramanian Shankar Akhilesh Pandey 《Clinical proteomics》2013,10(1):11
Background
Arthritis refers to inflammation of joints and includes common disorders such as rheumatoid arthritis (RA) and spondyloarthropathies (SpAs). These diseases differ mainly in terms of their clinical manifestations and the underlying pathogenesis. Glycoproteins in synovial fluid might reflect the disease activity status in the joints affected by arthritis; yet they have not been systematically studied previously. Although markers have been described for assisting in the diagnosis of RA, there are currently no known biomarkers for SpA.Materials and methods
We sought to determine the relative abundance of glycoproteins in RA and SpA by lectin affinity chromatography coupled to iTRAQ labeling and LC-MS/MS analysis. We also used ELISA to validate the overexpression of VCAM-1, one of the candidate proteins identified in this study, in synovial fluid from RA patients.Results and discussion
We identified proteins that were previously reported to be overexpressed in RA including metalloproteinase inhibitor 1 (TIMP1), myeloperoxidase (MPO) and several S100 proteins. In addition, we discovered several novel candidates that were overexpressed in SpA including Apolipoproteins C-II and C-III and the SUN domain-containing protein 3 (SUN3). Novel molecules found overexpressed in RA included extracellular matrix protein 1 (ECM1) and lumican (LUM). We validated one of the candidate biomarkers, vascular cell adhesion molecule 1 (VCAM1), in 20 RA and SpA samples using ELISA and confirmed its overexpression in RA (p-value <0.01). Our quantitative glycoproteomic approach to study arthritic disorders should open up new avenues for additional proteomics-based discovery studies in rheumatological disorders. 相似文献180.
Lakshmi Dhevi Nagarajha Selvan Jyothi Embekkat Kaviyil Raja Sekhar Nirujogi Babylakshmi Muthusamy Vinuth N Puttamallesh Tejaswini Subbannayya Nazia Syed Aneesha Radhakrishnan Dhanashree S Kelkar Sartaj Ahmad Sneha M Pinto Praveen Kumar Anil K Madugundu Bipin Nair Aditi Chatterjee Akhilesh Pandey Raju Ravikumar Harsha Gowda Thottethodi Subrahmanya Keshava Prasad 《Clinical proteomics》2014,11(1):1-16