Association between EZH2 expression,silencing of tumor suppressors and disease outcome in solid tumors

EZH2, the main catalytic component of the Polycomb Repressive Complex 2 (PRC2) is apparently upregulated in most solid tumors. Furthermore its expression generally associates with poor prognosis. It was proposed that this correlation reflects a causal event, EZH2 mediating the silencing of key tumor suppressor loci. In contrast, we recently showed that EZH2 is dispensable for solid tumor development and that its elevated expression reflects the abnormally high proliferation rate of cancer cells. Here, we investigate the functional association between EZH2 expression and silencing of key tumor suppressor loci and further illustrate the confounding effect of proliferation on EZH2′s association to outcome.     

Use of the BG 15 autoanalyzer for automatic recording and determination of ABO, Rhesus and Kell blood groups]

The use of the 15 channels blood grouping autoanalyzer with automated recording and interpretation proved its fiability through more than 30 000 tests for ABO, Rh and Kell determinations. Misreactions come mostly from the carry-over phenomenom. However no discrepancy was noticed for ABO determination. Only few ones occured for Rhesus and Kell, leading to false positive interpretations which were always corrected by checking the event recorder track. New improvements are expected from the automatic phasing using a microprocessor and further extents are setting up with the connection to a computer.