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991.
Xiaoyu Qu Huan Gao Lina Tao Yueming Zhang Jinghui Zhai Yanqing Song Sixi Zhang 《Journal of biochemical and molecular toxicology》2019,33(1)
The nucleotide‐binding oligomerization domain‐like receptor family, pyrin domain containing 3 (NLRP3) inflammasome has a key role in the inflammatory response. We found that cisplatin (7.5, 15 mg/kg, IV) could induce acute injury to the liver and kidneys of rats. Western blot and immunohistochemical analyses showed that expression of NLRP3, caspase‐1 and interleukin‐1β was upregulated significantly in a dose‐dependent manner after cisplatin exposure. Autophagy could inhibit NLRP3 expression and assembly of the NLRP3 inflammasome. Expression of light chain 3 II/I and p62 suggested that autophagy was inhibited during injury to the liver and kidneys. These data suggested that cisplatin might activate NLRP3 by inhibiting autophagy in the liver and kidneys of rats. 相似文献
992.
Yue Hou Jun Wang Jiaqing Liu Chuanxin Hou Zhaohong Xiu Yuqi Fan Lanling Zhao Yanjie Zhai Hongyu Li Jie Zeng Xiang Gao Shan Zhou Dongwei Li Yong Li Feng Dang Kang Liang Pu Chen Changming Li Dongyuan Zhao Biao Kong 《Liver Transplantation》2019,9(40)
The Li–O2 battery (LOB) represents a promising candidate for future electric vehicles owing to its outstanding energy density. However, the practical application of LOB cells is largely blocked by the poor cycling performance of cathode materials. Herein, an ultralong 440‐cycle life of an LOB cell is achieved using CeO2 nanocubes super‐assembled on an inverse opal carbon matrix as the cathode material without any additives. CeO2 is proved to be effective for the complete and sensitive decomposition of loosely stacked Li2O2 films during the oxygen evolution reaction process and full accommodation of volume changes caused by the fast growth of Li2O2 films during the oxygen reduction reaction process. The super‐assembled porous CeO2/C frameworks satisfy critical requirements including controlled size, morphology, high Ce3+/Ce4+ ratio, and efficient volume change accommodation, which dramatically increase the cycle life of LOB cell to 440 cycles. This study reveals the design strategy for high performance CeO2 catalyst cathodes for LOB cells and the generation mechanisms of Li2O2 films during the discharge process by using density functional theory calculations, showing new avenues for improving the future smart design of CeO2‐based cathode catalysts for Li–O2 batteries. 相似文献
993.
Huwei Wang Junyang Hu Jiahui Dong Kah Chun Lau Lei Qin Yu Lei Baohua Li Dengyun Zhai Yiying Wu Feiyu Kang 《Liver Transplantation》2019,9(43)
Secondary batteries based on earth‐abundant potassium metal anodes are attractive for stationary energy storage. However, suppressing the formation of potassium metal dendrites during cycling is pivotal in the development of future potassium metal‐based battery technology. Herein, a promising artificial solid‐electrolyte interphase (ASEI) design, simply covering a carbon nanotube (CNT) film on the surface of a potassium metal anode, is demonstrated. The results show that the spontaneously potassiated CNT framework with a stable self‐formed solid‐electrolyte interphase layer integrates a quasi‐hosting feature with fast interfacial ion transport, which enables dendrite‐free deposition of potassium at an ultrahigh capacity (20 mAh cm?2). Remarkably, the potassium metal anode exhibits an unprecedented cycle life (over 1000 cycles, over 2000 h) at a high current density of 5 mA cm?2 and a desirable areal capacity of 4 mAh cm?2. Dendrite‐free morphology in carbon‐fiber and carbon‐black‐based ASEI for potassium metal anodes, which indicates a broader promise of this approach, is also observed. 相似文献
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995.
Hu Zeng Shishi Wen Wei Xu Zhaoren He Guifa Zhai Yunkun Liu Zixin Deng Yuhui Sun 《Applied microbiology and biotechnology》2015,99(24):10575-10585
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Ziqiang Chen Bing Wu Xiao Zhai Yushu Bai Xiaodong Zhu Beier Luo Xiao Chen Chao Li Mingyuan Yang Kailiang Xu Chengcheng Liu Chuanfeng Wang Yingchuan Zhao Xianzhao Wei Kai Chen Wu Yang Dean Ta Ming Li 《PloS one》2015,10(4)
The purpose of this study was to understand the acoustic properties of human vertebral cancellous bone and to study the feasibility of ultrasound-based navigation for posterior pedicle screw fixation in spinal fusion surgery. Fourteen human vertebral specimens were disarticulated from seven un-embalmed cadavers (four males, three females, 73.14 ± 9.87 years, two specimens from each cadaver). Seven specimens were used to measure the transmission, including tests of attenuation and phase velocity, while the other seven specimens were used for backscattered measurements to inspect the depth of penetration and A-Mode signals. Five pairs of unfocused broadband ultrasonic transducers were used for the detection, with center frequencies of 0.5 MHz, 1 MHz, 1.5 MHz, 2.25 MHz, and 3.5 MHz. As a result, good and stable results were documented. With increased frequency, the attenuation increased (P<0.05), stability of the speed of sound improved (P<0.05), and penetration distance decreased (P>0.05). At about 0.6 cm away from the cortical bone, warning signals were easily observed from the backscattered measurements. In conclusion, the ultrasonic system proved to be an effective, moveable, and real-time imaging navigation system. However, how ultrasonic navigation will benefit pedicle screw insertion in spinal surgery needs to be determined. Therefore, ultrasound-guided pedicle screw implantation is theoretically effective and promising. 相似文献
999.
Xiaoding Ma Jian Ma Honghong Zhai Peiyong Xin Jinfang Chu Yongli Qiao Longzhi Han 《PloS one》2015,10(9)
CHD3 is one of the chromatin-remodeling factors that contribute to controlling the expression of genes associated with plant development. Loss-of-function mutants display morphological and growth defects. However, the molecular mechanisms underlying CHD3 regulation of plant development remain unclear. In this study, a rice CHD3 protein, CHR729, was identified. The corresponding mutant line (t483) exhibited late seed germination, low germination rate, dwarfism, low tiller number, root growth inhibition, adaxial albino leaves, and short and narrow leaves. CHR729 encoded a nuclear protein and was expressed in almost all organs. RNA-sequencing analysis showed that several plant hormone-related genes were up- or down-regulated in t483 compared to wild type. In particular, expression of the gibberellin synthetase gibberellin 20 oxidase 4 gene was elevated in the mutant. Endogenous gibberellin assays demonstrated that the content of bioactive GA3 was reduced in t483 compared to wild type. Moreover, the seedling dwarfism, late seed germination, and short root length phenotypes of t483 were partially rescued by treatment with exogenous GA3. These results suggest that the rice CHD3 protein CHR729 plays an important role in many aspects of seedling development and controls this development via the gibberellin pathway. 相似文献
1000.