排序方式: 共有12条查询结果,搜索用时 0 毫秒
11.
Ellanki AR Islam A Rama VS Pulipati RP Rambabu D Krishna GR Reddy CM Mukkanti K Vanaja GR Kalle AM Kumar KS Pal M 《Bioorganic & medicinal chemistry letters》2012,22(10):3455-3459
A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et(3)N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells. 相似文献
12.
Pal S Durgadas S Nallapati SB Mukkanti K Kapavarapu R Meda CL Parsa KV Pal M 《Bioorganic & medicinal chemistry letters》2011,21(21):6573-6576
A number of novel 1-(3-arylprop-2-ynyl) substituted 1,2-dihydroquinoline derivatives related to nimesulide and their 2-oxo analogues have been designed as potential inhibitors of PDE4. All these compounds were synthesized by using Sonogashira coupling as a key step. In vitro PDE4B inhibitory properties and molecular modeling studies of some of the compounds synthesized are presented. 相似文献