Chronic d-amphetamine in nucleus accumbens: Lack of tolerance or reverse tolerance of locomotor activity

An experiment was designed to test the ability of chronic intra-accumbens amphetamine injections to produce the augmentation of locomotor activity noted with repeated intraperitoneal injections. Results revealed increased response variability with chronic injections; but no augmentation or tolerance occurred, in spite of preservation of a dose dependent locomotor response to amphetamine in the nucleus accumbens.     

New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy

An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study.     

Coverage of bilateral lower extremity calcaneal fractures with osteomyelitis using a single split free gracilis muscle transfer

A case is presented in which a single gracilis muscle was split and used for free-tissue coverage of two sites in a patient with bilateral calcaneal fractures and posttraumatic osteomyelitis. Muscle-flap coverage of osteomyelitis and the use of the gracilis muscle for free-tissue transfer are discussed.