101.
Background
The phase-space relationship between simultaneously measured myoplasmic [Ca
2+] and isovolumetric left ventricular pressure (LVP) in guinea pig intact hearts is altered by ischemic and inotropic interventions.
Our objective was to mathematically model this phase-space relationship between [Ca
2+] and LVP with a focus on the changes in cross-bridge kinetics and myofilament Ca
2+ sensitivity responsible for alterations in Ca
2+-contraction coupling due to inotropic drugs in the presence and absence of ischemia reperfusion (IR) injury.
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