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91.
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93.
Ali Nokhodchi Ononuju N. Okwudarue Hadi Valizadeh Mohammad N. Momin 《AAPS PharmSciTech》2009,10(4):1243-1251
The aim of the present study was to explore the cogrinding technique as a tool to slow down the drug release from capsule
formulations. To this end, the physical mixtures of theophylline–magnesium stearate were prepared and subjected to different
milling times (1, 15, 30, 120 min). In order to investigate the effect of magnesium stearate concentration on drug release,
various concentrations of magnesium stearate (1%, 3%, 5%, and 10%, w/w) were used. The dissolution rate of the drug from coground samples and physical mixtures were determined at pH 6.5 according
to USP. The results showed that all coground formulations showed slower release rates than their physical mixture counterparts.
The effect of cogrinding time on the drug release was complex. Cogrinding time had no significant effect on drug release when
the amount of magnesium stearate was 1% (w/w). When the amount of magnesium stearate was increased from 1% to 3% and cogrinding time increased from 1 to 5 min, there
was a significant reduction in drug release. Beyond 5-min cogrinding, the drug release increased again. For coground samples
containing 5% or 10% (w/w) magnesium stearate, generally, the highest drug release was obtained at higher cogrinding time. This was due to a significant
increase in surface area of particles available for dissolution as proven by scanning electron microscopy results. Fourier
transform infrared and differential scanning calorimetry results ruled out any significant interaction between theophylline
and magnesium stearate in solid state. 相似文献
94.
M Morgan Conn Joe Kappock Dale Drueckhammer Richard Cammack Dennis Hall Tony Cass Jon D Stewart Graham RL Cousins Jeremy KM Sanders Sabine Flitsch Philip AS Lowden Richard Newman 《Current opinion in chemical biology》1999,3(6):631
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in chemical biology. 相似文献
95.
KM Abha Mishra Runesh Podili Teja S. Pathlavath Kalyan K. Sethi 《Journal of biochemical and molecular toxicology》2023,37(8):e23409
Since the outbreak of highly virulent coronaviruses, significant interest was assessed to the brain and heart axis (BHA) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-affected patients. The majority of clinical reports accounted for unusual symptoms associated with SARS-CoV-2 infections which are of the neurological type, such as headache, nausea, dysgeusia, anosmia, and cerebral infarction. The SARS-CoV-2 enters the cells through the angiotensin-converting enzyme (ACE-2) receptor. Patients with prior cardiovascular disease (CVD) have a higher risk of COVID-19 infection and it has related to various cardiovascular (CV) complications. Infected patients with pre-existing CVDs are also particularly exposed to critical health outcomes. Overall, COVID-19 affected patients admitted to intensive care units (ICU) and exposed to stressful environmental constraints, featured with a cluster of neurological and CV complications. In this review, we summarized the main contributions in the literature on how SARS-CoV-2 could interfere with the BHA and its role in affecting multiorgan disorders. Specifically, the central nervous system involvement, mainly in relation to CV alterations in COVID-19-affected patients, is considered. This review also emphasizes the biomarkers and therapy options for COVID-19 patients presenting with CV problems. 相似文献
96.
97.
Catabolism of arginine, citrulline and ornithine by Pseudomonas and related bacteria 总被引:3,自引:0,他引:3
The distribution of the arginine succinyltransferase pathway was examined in representative strains of Pseudomonas and related bacteria able to use arginine as the sole carbon and nitrogen source for growth. The arginine succinyltransferase pathway was induced in arginine-grown cells. The accumulation of succinylornithine following in vivo inhibition of succinylornithine transaminase activity by aminooxyacetic acid showed that this pathway is responsible for the dissimilation of the carbon skeleton of arginine. Catabolism of citrulline as a carbon source was restricted to relatively few of the organisms tested. In P. putida, P. cepacia and P. indigofera, ornithine was the main product of citrulline degradation. In most strains which possessed the arginine succinyltransferase pathway, the first step of ornithine utilization as a carbon source was the conversion of ornithine into succinylornithine through an ornithine succinyltransferase. However P. cepacia and P. putida used ornithine by a pathway which proceeded via proline as an intermediate and involved an ornithine cyclase activity. 相似文献
98.
Momin Bilal Rahman Shakeelur Jha Neetu Annapure Uday S. 《Bioprocess and biosystems engineering》2019,42(4):541-553
Bioprocess and Biosystems Engineering - The present study reports the optimization of a green method for the synthesis of silver nanoparticles (AgNPs) via reduction of Ag+ ions using... 相似文献