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741.
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Pheromone deactivation catalyzed by receptor molecules: a quantitative kinetic model 总被引:9,自引:5,他引:4
A quantitative model of pheromone-receptor interaction and pheromone
deactivation, the supposed rate-limiting processes underlying the receptor
potential kinetics, is worked out for the moth Antheraea polyphemus. In
this model, the pheromone interacts with the receptor molecule while bound
to the reduced form of the pheromone binding protein. The receptor
molecules--besides their receptor function-- catalyze the observed shift of
the pheromone-binding protein from the reduced to the oxidized form
(Ziegelberger, G., Eur. J. Biochem., 232, 706-711, 1995), which deactivates
the pheromone bound to pheromone binding protein. With the following
parameters, the model fits morphological, radiometric, electrophysiological
and biochemical data: a maximum estimate of 1.7 x 10(7) receptor
molecules/cell (with 40,000 units/micron 2 of receptor cell membrane), rate
constants k1 = 0.2/(s.microM) for the association, k2 = 10/s for the
dissociation of the ternary complex of binding protein, pheromone and
receptor, and k3 = 10/s for the deactivation via the redox shift. With
these parameters, the duration of elementary receptor potentials elicited
by single pheromone molecules (approximately 50 ms) reflects the lifetime
of the ternary complex, tau = 1/(k2 + k3). The receptor occupancy produced
by the model for threshold stimuli fits the sensitivity of the receptor
cell to single pheromone molecules.
相似文献
747.
748.
Background
A logical model of the known metabolic processes in S. cerevisiae was constructed from iFF708, an existing Flux Balance Analysis (FBA) model, and augmented with information from the KEGG online pathway database. The use of predicate logic as the knowledge representation for modelling enables an explicit representation of the structure of the metabolic network, and enables logical inference techniques to be used for model identification/improvement. 相似文献749.
Dose-response curves relating the external stimulus concentration to
receptor occupancy differ in two types of chemoreceptor organs. In
'concentration detectors' the receptor molecules at the receptor cell
membrane are directly exposed to the external stimulus concentration; these
organs exhibit the well-known hyperbolic dose-response relationship
reflecting the association-dissociation of stimulus and receptor molecules.
In contrast, 'flux detectors' accumulate the stimulus molecules in a
perireceptor compartment. In flux detectors, deactivation of stimulus
molecules may be in balance with arrival, as a prerequisite for producing a
constant effective stimulus concentration at constant adsorptive flux of
stimulus molecules. In a simple model of a flux detector in which receptor
molecules themselves catalyze the deactivation, the dose-response
relationship is linear. It reflects the rate of stimulus deactivation. If
the deactivation is catalyzed by a separate enzyme, the dose-response
relationship can be close to hyperbolic, or linear. In all cases, the
receptor molecules are maximally occupied if the adsorptive flux equals or
exceeds the maximum rate of stimulus deactivation. The time course of the
receptor potential recorded from moths' pheromone receptors depends on the
odor compound, which suggests that a peripheral process, possibly the
stimulus deactivation, is the slowest, rate-limiting process of the
transduction cascade. Further evidence comes from experiments with stimuli
oversaturating the mechanism responsible for the decline of the receptor
potential.
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