A Novel Graphene Oxide Wrapped Na2Fe2(SO4)3/C Cathode Composite for Long Life and High Energy Density Sodium‐Ion Batteries

The cathode materials in the Na‐ion battery system are always the key issue obstructing wider application because of their relatively low specific capacity and low energy density. A graphene oxide (GO) wrapped composite, Na₂Fe₂(SO₄)₃@C@GO, is fabricated via a simple freeze‐drying method. The as‐prepared material can deliver a 3.8 V platform with discharge capacity of 107.9 mAh g^?1 at 0.1 C (1 C = 120 mA g^?1) as well as offering capacity retention above 90% at a discharge rate of 0.2 C after 300 cycles. The well‐constructed carbon network provides fast electron transfer rates, and thus, higher power density also can be achieved (75.1 mAh g^?1 at 10 C). The interface contribution of GO and Na₂Fe₂(SO₄)₃ is recognized and studied via density function theory calculation. The Na storage mechanism is also investigated through in situ synchrotron X‐ray diffraction, and pseudocapacitance contributions are also demonstrated. The diffusion coefficient of Na⁺ ions is around 10^?12–10^?10.8 cm² s^?1 during cycling. The higher working voltage of this composite is mainly ascribed to the larger electronegativity of the element S. The research indicates that this well‐constructed composite would be a competitive candidate as a cathode material for Na‐ion batteries.     

Reverse Genetics for Peste des Petits Ruminants Virus: Current Status and Lessons to Learn from Other Non-segmented Negative-Sense RNA Viruses

Peste des petits ruminants (PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus (PPRV) pathobiology and molecular biology is critical for effective control and eradication of the disease. To achieve these goals, establishment of stable reverse genetics systems for PPRV would play a key role. Unfortunately, this powerful technology remains less accessible and poorly documented for PPRV. In this review, we discussed the current status of PPRV reverse genetics as well as the recent innovations and advances in the reverse genetics of other non-segmented negative-sense RNA viruses that could be applicable to PPRV. These strategies may contribute to the improvement of existing techniques and/or the development of new reverse genetics systems for PPRV.     

Short-Term Responders of Non–Small Cell Lung Cancer Patients to EGFR Tyrosine Kinase Inhibitors Display High Prevalence of TP53 Mutations and Primary Resistance Mechanisms

Non–small cell lung cancer (NSCLC) with activating EGFR mutations in exon 19 and 21 typically responds to EGFR tyrosine kinase inhibitors (TKI); however, for some patients, responses last only a few months. The underlying mechanisms of such short responses have not been fully elucidated. Here, we sequenced the genomes of 16 short-term responders (SR) that had progression-free survival (PFS) of less than 6 months on the first-generation EGFR TKI and compared them to 12 long-term responders (LR) that had more than 24 months of PFS. All patients were diagnosed with advanced lung adenocarcinoma and harbored EGFR 19del or L858R mutations before treatment. Paired tumor samples collected before treatment and after relapse (or at the last follow-up) were subjected to targeted next-generation sequencing of 416 cancer-related genes. SR patients were significantly younger than LR patients (P < .001). Collectively, 88% of SR patients had TP53 variations compared to 13% of LR patients (P < .001). Additionally, 37.5% of SR patients carried EGFR amplifications compared to 8% of LR patients. Other potential primary resistance factors were also identified in the pretreatment samples of 12 SR patients (75%), including PTEN loss; BIM deletion polymorphism; and amplifications of EGFR, ERBB2, MET, HRAS, and AKT2. Comparatively, only three LR patients (25%) were detected with EGFR or AKT1 amplifications that could possibly exert resistance. The diverse preexisting resistance mechanisms in SR patients revealed the complexity of defining treatment strategies even for EGFR-sensitive mutations.     

银杏光合与蒸腾特性的研究

通过测定银杏净光合速率、蒸腾速度、气孔阻力等生理指标和观测银杏叶片形态、解剖特征,结果表明：１．银杏光补偿点为７６μｍｏｌ．ｍ＾－１．ｓ＾－１,光饱和点为１０４０μｍｏｌ．ｍ＾－２．ｓ＾－１。超过光饱和点后,随光照强度增加光合强度反而下降。２．银杏光合最佳温度为２６℃。３．净光 速率的日变化呈“午休”型的双峰曲线变化,最高峰出现在１０：００Ａ．Ｍ．前后,次峰出现在６：００Ｐ．Ｍ．前后。４．蒸腾速度     

Persistence and Periodic Solutions of a System of Two Competing Species with Functional Response

1IntroductionOneofthemOStnit~tingquestionsinrnathernaticalbiologyconcernsthesurvivalofspeCiesinecologiCalmodels.Perslstenceisanimportantconceptindabingwiththeseproblems.Therearemanyliteraturesaboutthedy'ndricsofdiffuSivecompetingspeCies,butthefunctionalresPOnseofthisfOITnhasnotbeenst'Udiedtoomuchyet.Inthispaper,weconsiderthepersistenceproblemforanonautonomoussystemoftwOcompetingspecieswithfunctionalreSPOnse,themodelweconsiderinthispaperishereallri(t),ail(t),D,(t)anda(t)areassumedtobecon…     

Ischemic flap survival improvement by composition-selective fat grafting with novel adipose tissue derived product - stromal vascular fraction gel

Background

Flap necrosis due to insufficient blood supply is a common postoperative complication in random pattern flaps. Stem cell therapies have emerged as promising biologics for tissue ischemia. A novel fat derived product, stromal vascular fraction gel (SVF-gel), can be prepared with lipoaspirate through simple mechanical processing, removing only the lipid content. SVF-gel enriches adipose-derived stem cells and potentially beneficial for flap necrosis.