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551.
Katherine Costil Juliette Royer Michel Ropert Patrick Soletchnik Michel Mathieu 《Helgoland Marine Research》2005,59(4):286-300
Mortality and biological performances of half-grown Crassostrea gigas were studied from spring 2000 to autumn 2001 at six instrumented stations located in two areas (Gefosse and Grandcamp) of
the Bay of Veys (Normandy). Shell and meat growth, condition indexes and a macroscopic maturity index were determined on oysters
deployed at the six stations in order to assess spatial variability in the influence of environmental conditions. In addition,
histological and biochemical analyses were performed in order to determine the sex and establish the reproductive cycle (at
all six sites) and the biochemical composition (at four stations). The data set including monthly mean temperatures and data
provided by examination of 2,837 oysters were analysed by Principal Component Analysis and a Hierarchical Ascending Clustering
which resulted in the formation of four clusters. The highest station on the shoreline belonged to a cluster characterized
notably by low total weight due to a short immersion/feeding period, whereas all other stations belonged to another single
cluster. Nevertheless, various biological differences were found between these stations, e.g. the reproductive cycle was generally
synchronized throughout the bay but some differences relative to spawning occurrence were observed. In 2000, oyster mortality
was higher at Gefosse than at Grandcamp, the latter being a more marine area. In 2001, oyster mortalities were significantly
higher and all stations were strongly affected. In the Bay of Veys, oyster biological performances and mortality thus showed
spatio-temporal variations which were worthy to be discussed. 相似文献
552.
553.
Sinéad Collins Juliette de Meaux 《Evolution; international journal of organic evolution》2009,63(11):2952-2965
We investigate how different rates of environmental change affect adaptive outcomes and dynamics by selecting Chlamydomonas populations for over 200 generations in environments where the rate of change varies. We find that slower rates of environmental change result in end populations that grow faster and pay a lower cost of adaptation than populations that adapt to a sudden change of the same magnitude. We detected partial selective sweeps in adapting populations by monitoring changes in marker frequency in each population. Although populations adapting to a sudden environmental change showed evidence of mutations of large effect segregating early on, populations adapting to slow rates of change showed patterns that were consistent with mutations of relatively small effect occurring at less predictable times. This work suggests that rates of environmental change may fundamentally alter adaptive dynamics and outcomes of adaptation by changing the size and timing of fitness increases. We suggest that using mutations of smaller effect during adaptation may result in lower levels of pleiotropy and historical constraints, which could in turn result in higher fitness by the end of the experiment. 相似文献
554.
Juliette Contandriopoulos 《Plant Systematics and Evolution》1978,129(4):277-289
The author has proceeded with a cytotaxonomical study of the genusSideritis L. Chromosome numbers (mostly new) are reported for about twenty taxa from sectionEmpedoclea (Rafin.)Benth. This section occupies a very isolated position within the genus and has evolved quite independently. 相似文献
555.
Thierry Tribout Nathalie Iannuccelli Tom Druet Hélène Gilbert Riquet Juliette Gueblez Ronan Marie-José Mercat Jean-Pierre Bidanel Denis Milan Pascale Le Roy 《遗传、选种与进化》2008,40(1):61-78
A genome-wide scan was performed in Large White and French Landrace pig populations in order to identify QTL affecting reproduction and production traits. The experiment was based on a granddaughter design, including five Large White and three French Landrace half-sib families identified in the French porcine national database. A total of 239 animals (166 sons and 73 daughters of the eight male founders) distributed in eight families were genotyped for 144 microsatellite markers. The design included 51 262 animals recorded for production traits, and 53 205 litter size records were considered. Three production and three reproduction traits were analysed: average backfat thickness (US_M) and live weight (LWGT) at the end of the on-farm test, age of candidates adjusted at 100 kg live weight, total number of piglets born per litter, and numbers of stillborn (STILLp) and born alive (LIVp) piglets per litter. Ten QTL with medium to large effects were detected at a chromosome-wide significance level of 5% affecting traits US_M (on SSC2, SSC3 and SSC17), LWGT (on SSC4), STILLp (on SSC6, SSC11 and SSC14) and LIVp (on SSC7, SSC16 and SSC18). The number of heterozygous male founders varied from 1 to 3 depending on the QTL. 相似文献
556.
Giulia Cerrato Marion Leduc Kevin Müller Peng Liu Liwei Zhao Juliette Humeau Wei Xie Shuai Zhang Oliver Kepp Allan Sauvat Guido Kroemer 《Cell death and differentiation》2021,28(5):1733
Oleate, the most abundant endogenous and dietary cis-unsaturated fatty acid, has the atypical property to cause the redistribution of microtubule-associated proteins 1A/1B light chain 3B (referred to as LC3) to the trans-Golgi network (TGN), as shown here. A genome-wide screen identified multiple, mostly Golgi transport-related genes specifically involved in the oleate-induced relocation of LC3 to the Golgi apparatus. Follow-up analyses revealed that oleate also caused the retention of secreted proteins in the TGN, as determined in two assays in which the secretion of proteins was synchronized, (i) an assay involving a thermosensitive vesicular stomatitis virus G (VSVG) protein that is retained in the endoplasmic reticulum (ER) until the temperature is lowered, and (ii) an isothermic assay involving the reversible retention of the protein of interest in the ER lumen and that was used both in vitro and in vivo. A pharmacological screen searching for agents that induce LC3 aggregation at the Golgi apparatus led to the identification of “oleate mimetics” that share the capacity to block conventional protein secretion. In conclusion, oleate represents a class of molecules that act on the Golgi apparatus to cause the recruitment of LC3 and to stall protein secretion.Subject terms: Autophagy, Proteins 相似文献
557.
Young-Seuk Park Juliette Tison Sovan Lek Jean-Luc Giraudel Michel Coste Franois Delmas 《Ecological Informatics》2006,1(3):247
Ecological communities consist of a large number of species. Most species are rare or have low abundance, and only a few are abundant and/or frequent. In quantitative community analysis, abundant species are commonly used to interpret patterns of habitat disturbance or ecosystem degradation. Rare species cause many difficulties in quantitative analysis by introducing noises and bulking datasets, which is worsened by the fact that large datasets suffer from difficulties of data handling. In this study we propose a method to reduce the size of large datasets by selecting the most ecologically representative species using a self organizing map (SOM) and structuring index (SI). As an example, we used diatom community data sampled at 836 sites with 941 species throughout the French hydrosystem. Out of the 941 species, 353 were selected. The selected dataset was effectively classified according to the similarities of community assemblages in the SOM map. Compared to the SOM map generated with the original dataset, the community pattern gave a very similar representation of ecological conditions of the sampling sites, displaying clear gradients of environmental factors between different clusters. Our results showed that this computational technique can be applied to preprocessing data in multivariate analysis. It could be useful for ecosystem assessment and management, helping to reduce both the list of species for identification and the size of datasets to be processed for diagnosing the ecological status of water courses. 相似文献
558.
Background
Secondary structure prediction is a useful first step toward 3D structure prediction. A number of successful secondary structure prediction methods use neural networks, but unfortunately, neural networks are not intuitively interpretable. On the contrary, hidden Markov models are graphical interpretable models. Moreover, they have been successfully used in many bioinformatic applications. Because they offer a strong statistical background and allow model interpretation, we propose a method based on hidden Markov models. 相似文献559.
560.
Emile Van Schaftingen Ghislain Delpierre Franois Collard Juliette Fortpied Rita Gemayel Elsa Wiame Maria Veiga-da-Cunha 《Advances in enzyme regulation》2007,47(1):261-269
FN3K is a recently identified enzyme that phosphorylates both low-molecular-weight and protein-bound fructosamines. Fructosamine 3-phosphates are unstable, breaking down spontaneously to 3-deoxyglucosone, inorganic phosphate and the amino compound that originally reacted with glucose. FN3K is therefore a ‘deglycating’ enzyme. Evidence has been provided for the fact that this enzyme indeed removes a significant proportion of the fructosamine residues that form on hemoglobin in erythrocytes. Recent results obtained with FN3K-deficient mice confirm that FN3K acts as a protein deglycating enzyme in tissues.Unlike FN3K, FN3K-RP does not act on fructosamines, but it does phosphorylate ketoamines with a D configuration in C3 (ribulosamines, erythrulosamines and, with a lower affinity, psicosamines). The ketoamine 3-phosphates that are formed by FN3K-RP are also unstable and their spontaneous decomposition leads to the regeneration of a free amino group, indicating that FN3K-RP is also a protein repair enzyme. This role has been confirmed in human erythrocytes, which are rich in FN3K-RP. Remarkably, the single FN3K–FN3K-RP homologue that is present in fishes, plants and bacteria appears to be also a ribulosamine/erythrulosamine 3-kinase, indicating that the repair of ribulosamines or erythrulosamines may be more important than the removal of fructosamines.Ribulosamines and erythrulosamines most likely arise through a reaction of proteins with ribose 5-phosphate and erythrose 4-phosphate, two extremely potent glycating agents. The ribulosamine 5-phosphates and erythrulosamine 4-phosphates that are formed in this way must be dephosphorylated by a phosphatase that still needs to be identified. Glucose 6-phosphate is also a potent glycating agent, and a phosphatase acting best on protein-bound fructosamine 6-phosphates has recently been identified.In conclusion, protein deglycation appears to involve a whole set of enzymes. A key question for future investigations is why it is important to rid proteins of their sugar adducts rather than replace them with newly synthesized macromolecules. 相似文献