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911.
Danny P. C. McGee John C. Martin Donald F. Smee Julien P. H. Verheyden 《Nucleosides, nucleotides & nucleic acids》2013,32(6):815-826
Abstract The synthesis of 3-deaza-DHPG 2 and its positional isomer 10 via the acid catalysed fusion of imidazole 3 and acetoxymethylglycerol 4 is described. Analogue 2 has activity against herpes simplex viruses and cytomegalovirus. 相似文献
912.
913.
Julien Pothlichet Isabelle Meunier Beckley K. Davis Jenny P-Y. Ting Emil Skamene Veronika von Messling Silvia M. Vidal 《PLoS pathogens》2013,9(4)
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1β response is mediated by innate receptors in macrophages and lung epithelial cells. NLRP3 is crucial in macrophages; however, which sensors elicit IL-1β secretion in lung epithelial cells remains undetermined. Here, we describe for the first time the relative roles of the host innate receptors RIG-I (DDX58), TLR3, and NLRP3 in the IL-1β response to IAV in primary lung epithelial cells. To activate IL-1β secretion, these cells employ partially redundant recognition mechanisms that differ from those described in macrophages. RIG-I had the strongest effect through a MAVS/TRIM25/Riplet–dependent type I IFN signaling pathway upstream of TLR3 and NLRP3. Notably, RIG-I also activated the inflammasome through interaction with caspase 1 and ASC in primary lung epithelial cells. Thus, NS1, an influenza virulence factor that inhibits the RIG-I/type I IFN pathway, strongly modulated the IL-1β response in lung epithelial cells and in ferrets. The NS1 protein derived from a highly pathogenic strain resulted in increased interaction with RIG-I and inhibited type I IFN and IL-1β responses compared to the least pathogenic virus strains. These findings demonstrate that in IAV-infected lung epithelial cells RIG-I activates the inflammasome both directly and through a type I IFN positive feedback loop. 相似文献
914.
Jean-Philippe Julien Devin Sok Reza Khayat Jeong Hyun Lee Katie J. Doores Laura M. Walker Alejandra Ramos Devan C. Diwanji Robert Pejchal Albert Cupo Umesh Katpally Rafael S. Depetris Robyn L. Stanfield Ryan McBride Andre J. Marozsan James C. Paulson Rogier W. Sanders John P. Moore Dennis R. Burton Pascal Poignard Andrew B. Ward Ian A. Wilson 《PLoS pathogens》2013,9(5)
915.
916.
The role of biotic interactions in shaping distributions and realised assemblages of species: implications for species distribution modelling 总被引:1,自引:0,他引:1
Mary Susanne Wisz Julien Pottier W. Daniel Kissling Loïc Pellissier Jonathan Lenoir Christian F. Damgaard Carsten F. Dormann Mads C. Forchhammer John‐Arvid Grytnes Antoine Guisan Risto K. Heikkinen Toke T. Høye Ingolf Kühn Miska Luoto Luigi Maiorano Marie‐Charlotte Nilsson Signe Normand Erik Öckinger Niels M. Schmidt Mette Termansen Allan Timmermann David A. Wardle Peter Aastrup Jens‐Christian Svenning 《Biological reviews of the Cambridge Philosophical Society》2013,88(1):15-30
Predicting which species will occur together in the future, and where, remains one of the greatest challenges in ecology, and requires a sound understanding of how the abiotic and biotic environments interact with dispersal processes and history across scales. Biotic interactions and their dynamics influence species' relationships to climate, and this also has important implications for predicting future distributions of species. It is already well accepted that biotic interactions shape species' spatial distributions at local spatial extents, but the role of these interactions beyond local extents (e.g. 10 km2 to global extents) are usually dismissed as unimportant. In this review we consolidate evidence for how biotic interactions shape species distributions beyond local extents and review methods for integrating biotic interactions into species distribution modelling tools. Drawing upon evidence from contemporary and palaeoecological studies of individual species ranges, functional groups, and species richness patterns, we show that biotic interactions have clearly left their mark on species distributions and realised assemblages of species across all spatial extents. We demonstrate this with examples from within and across trophic groups. A range of species distribution modelling tools is available to quantify species environmental relationships and predict species occurrence, such as: (i) integrating pairwise dependencies, (ii) using integrative predictors, and (iii) hybridising species distribution models (SDMs) with dynamic models. These methods have typically only been applied to interacting pairs of species at a single time, require a priori ecological knowledge about which species interact, and due to data paucity must assume that biotic interactions are constant in space and time. To better inform the future development of these models across spatial scales, we call for accelerated collection of spatially and temporally explicit species data. Ideally, these data should be sampled to reflect variation in the underlying environment across large spatial extents, and at fine spatial resolution. Simplified ecosystems where there are relatively few interacting species and sometimes a wealth of existing ecosystem monitoring data (e.g. arctic, alpine or island habitats) offer settings where the development of modelling tools that account for biotic interactions may be less difficult than elsewhere. 相似文献
917.
918.
Julien Farard Gaëtan Lanceart Cedric Logé Marie-Renée Nourrisson Francisco Cruzalegui Bruno Pfeiffer 《Journal of enzyme inhibition and medicinal chemistry》2013,28(5):629-640
Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. Inhibiting the catalytic activity of these proteins has become one of the major therapeutic concepts in contemporary drug discovery. We report here the design and the synthesis of novel 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential inhibitors of Src kinase. The synthesis of these derivatives and the preliminary results of biological activity will be discussed. 相似文献
919.
920.
Avigliano Esteban Pisonero Jorge Bouchez Julien Pouilly Marc Domanico Alejandro Sánchez Sebastian Clavijo Cristhian Scarabotti Pablo Facetti Juan F. Caffetti Jacqueline D. del Rosso Franco R. Llamazares Vegh Sabina Volpedo Alejandra V. 《Environmental Biology of Fishes》2021,104(3):277-292
Environmental Biology of Fishes - The potential use of Sr/Ca and Ba/Ca ratios in fish otolith, as a complement to 87Sr/86Sr to study movements of Prochilodus lineatus, was evaluated in the La Plata... 相似文献