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131.
A 36-year-old man suffering from chronic myeloid leukemia (in chronic phase) was initially treated with busulphan. At the
end of 6 months of follow-up he developed bone marrow aplasia. He was given single foetal liver infusion therapy. The patient
recovered fully from aplasia. He continued in chronic phase for more than 7 years with intermittent busulphan therapy. 相似文献
132.
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134.
Transduction, the transfer of genetic information from one bacterial host to another by bacteriophage, has been demonstrated
inMycobacterium phlei. The ability to utilized-xylose as a sole carbon source could be transferred fromM. phlei strain SN109 (xyl
+,str-s) toM. phlei strain F89 (xyl
−,str-r) by a bacterially sterile, DNase-treated phage Bo2-lysate of donorM. phlei SN109. The marker was expressed within 15 minutes of phage infection, but the recipient bacteria had to be in early stationary
phase for transduction to occur. Controls employed in these experiments were bacteria incubated with heat-killed phage, with
phage plus antiphage serum, or with sterile broth in place of phage. Phage conversion, the appearance of a new character due
solely to phage infection, could not account for the observed phenomenon since phage Bo2, which was not previously propagated
on axyl
+ donor, failed to confer the ability to utilize xylose on axyl
− repicient.
High frequency transduction (HFT) also could be demonstrated by using phage lysates obtained fromxyl
+ transductants.
This work was presented in part at the 71st Annual Meeting of the American Society for Microbiology, Minneapolis, 2–8 May,
1971. Submitted by the senior author in partial fulfillment of the requirement for the Ph.D. degree at the Department of Microbiology,
Loyola University — Stritch School of Medicine, Maywood, Illinois. 相似文献
135.
Sudhanshu Sudan HP Vasantha Rupasinghe 《Experimental biology and medicine (Maywood, N.J.)》2015,240(11):1452-1464
Despite their strong role in human health, poor bioavailability of flavonoids limits their biological effects in vivo. Enzymatically catalyzed acylation of fatty acids to flavonoids is one of the approaches of increasing cellular permeability and hence, biological activities. In this study, six long chain fatty acid esters of quercetin-3-O-glucoside (Q3G) acylated enzymatically and were used for determining their antiproliferative action in hepatocellular carcinoma cells (HepG2) in comparison to precursor compounds and two chemotherapy drugs (Sorafenib and Cisplatin). Fatty acid esters of Q3G showed significant inhibition of HepG2 cell proliferation by 85 to 90% after 6 h and 24 h of treatment, respectively. The cell death due to these novel compounds was associated with cell-cycle arrest in S-phase and apoptosis observed by DNA fragmentation, fluorescent microscopy and elevated caspase-3 activity and strong DNA topoisomerase II inhibition. Interestingly, Q3G esters showed significantly low toxicity to normal liver cells than Sorafenib (P < 0.05), a chemotherapy drug for hepatocellular carcinoma. Among all, oleic acid ester of Q3G displayed the greatest antiproliferation action and a high potential as an anti-cancer therapeutic. Overall, the results of the study suggest strong antiproliferative action of these novel food-derived compounds in treatment of cancer. 相似文献
136.
Cluster Computing - High-density, high-sampling rate EEG measurements generate large amounts of measurement data. When coupled with sophisticated processing methods, this presents a storage,... 相似文献
137.
Edward J. Takach Wade M. Hines Dale H. Patterson Peter Juhasz Arnold M. Falick Marvin L. Vestal Stephen A. Martin 《Journal of Protein Chemistry》1997,16(5):363-369
Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is now an essential tool in biopolymer analysis. Sensitivity and mass range are unsurpassed, but mass measurement accuracy and resolution have been limited. With delayed extraction and a reflecting analyzer, mass measurements using MALDI-TOF can be made with an accuracy of a few parts per million (ppm). It is possible to distinguish Lys from Gln in peptides, and to determine the elemental composition of smaller molecules (mass 100–500). In database searching strategies, a smaller mass window, resulting from an increase in mass accuracy, greatly decreases the number of possible candidates. Mass measurement accuracy with errors less than 5 ppm is demonstrated on a mixture of 12 peptides ranging in mass from ca. 900 to 3700 Da. Mass measurements on 13 peaks in an unseparated tryptic digest of myoglobin gave results with an overall average error less than 3.5 ppm, with a maximum error of 7 ppm. 相似文献