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121.
LncRNA LEF1-AS1 promotes osteogenic differentiation of dental pulp stem cells via sponging miR-24-3p
Molecular and Cellular Biochemistry - Alzheimer’s disease (AD) is the leading cause of dementia, which characterized by toxic senile plaques is composed of amyloid-β (Aβ).... 相似文献
122.
Yang Xuefang He Yingying Song Xi’E Yuan Xiangyang Li Yongfeng Sun Dasheng 《Plant and Soil》2020,448(1-2):369-381
Plant and Soil - The incidence of herbicide-resistant blackgrass is escalating in wheat fields; the development of alternatives to traditional herbicides is crucial. Allelopathic wheat can suppress... 相似文献
123.
Kumar P. S. Ling C. Y. Zhou Z. B. Dong Y. L. Sun C. L. Song Y. X. Wong N. K. Ju J. H. 《Microbiology》2020,89(4):483-492
Microbiology - Marine actinobacteria particularly from marine environments are believed to be inexhaustible sources of biologically active molecules for biomedical and industrial applications. We... 相似文献
124.
Xu Feng Peng Feng Huilin Yu Xingyu Yu Qi Sun Siyu Liu Thuy Nguyen Minh Jun Chen Di Wang Qing Zhang Lei Cao Changmei Zhou Qiang Li Jialei Xiao Shihua Zhong Aoxue Wang Lijuan Wang Hongyu Pan Xiaodong Ding 《Plant, cell & environment》2020,43(5):1192-1211
Although the function and regulation of SnRK1 have been studied in various plants, its molecular mechanisms in response to abiotic stresses are still elusive. In this work, we identified an AP2/ERF domain-containing protein (designated GsERF7) interacting with GsSnRK1 from a wild soybean cDNA library. GsERF7 gene expressed dominantly in wild soybean roots and was responsive to ethylene, salt, and alkaline. GsERF7 bound GCC cis-acting element and could be phosphorylated on S36 by GsSnRK1. GsERF7 phosphorylation facilitated its translocation from cytoplasm to nucleus and enhanced its transactivation activity. When coexpressed in the hairy roots of soybean seedlings, GsSnRK1(wt) and GsERF7(wt) promoted plants to generate higher tolerance to salt and alkaline stresses than their mutated species, suggesting that GsSnRK1 may function as a biochemical and genetic upstream kinase of GsERF7 to regulate plant adaptation to environmental stresses. Furthermore, the altered expression patterns of representative abiotic stress-responsive and hormone-synthetic genes were determined in transgenic soybean hairy roots after stress treatments. These results will aid our understanding of molecular mechanism of how SnRK1 kinase plays a cardinal role in regulating plant stress resistances through activating the biological functions of downstream factors. 相似文献
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127.
Zhang Huan Sun Gaigai Lin Zhihua Yao Hanhan Dong Yinghui 《Molecular biology reports》2020,47(12):9579-9593
Molecular Biology Reports - High ammonia can inhibit the survival and growth, and even cause mortality of razor clam (S. constricta). The accumulation of ammonia to lethal concentrations in some... 相似文献
128.
Li-Min Lu Hai-Hua Hu Dan-Xiao Peng Bing Liu Jian-Fei Ye Tuo Yang Hong-Lei Li Miao Sun Stephen A. Smith Pamela S. Soltis Douglas E. Soltis Zhi-Duan Chen 《Journal of Biogeography》2020,47(10):2286-2291
In response to our paper on the evolutionary history of the Chinese flora, Qian suggests that certain features of the divergence time estimation employed might have led to biased conclusions in Lu et al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty in the data and demonstrate that (i) no systematic bias toward dates that are too young or too old is detected in Lu et al.; (ii) constraint of the crown age of angiosperms does not bias the generic ages estimated by Lu et al.; and (iii) ages derived from the Chinese regional phylogeny do not bias the conclusions reported by Lu et al. All these analyses confirm that the conclusions reported previously are robust. We argue that, like many large-scale biodiversity analyses, sources of noise in divergence time estimation are to be expected, but these should not be confused with bias. 相似文献
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130.
Shaochen Fan Huasong Gao Wei Ji Fengwei Zhu Lingzheng Sun Yuankun Liu Siming Zhang Yanran Xu Yaohua Yan Yilu Gao 《Journal of cellular physiology》2020,235(2):1769-1779
Although much progress has been made in the treatment of gliomas, the prognosis for patients with gliomas is still very poor. Stem cell-based therapies may be promising options for glioma treatment. Recently, many studies have reported that umbilical cord-derived mesenchymal stromal/stem cells (UC-MSCs) are ideal gene vehicles for tumor gene therapy. Interleukin 24 (IL-24) is a pleiotropic immunoregulatory cytokine that has an apoptotic effect on many kinds of tumor cells and can inhibit the growth of tumors specifically without damaging normal cells. In this study, we investigated UC-MSCs as a vehicle for the targeted delivery of IL-24 to tumor sites. UC-MSCs were transduced with lentiviral vectors carrying green fluorescent protein (GFP) or IL-24 complementary DNA. The results indicated that UC-MSCs could selectively migrate to glioma cells in vitro and in vivo. Injection of IL-24-UC-MSCs significantly suppressed tumor growth of glioma xenografts. The restrictive efficacy of IL-24-UC-MSCs was associated with the inhibition of proliferation as well as the induction of apoptosis in tumor cells. These findings indicate that UC-MSC-based IL-24 gene therapy may be able to suppress the growth of glioma xenografts, thereby suggesting possible future therapeutic use in the treatment of gliomas. 相似文献