排序方式: 共有111条查询结果,搜索用时 15 毫秒
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Luciane Viater Turek Neiva Leite Ricardo Lehtonen Rodrigues Souza Jovana Karoline Lima Gerusa Eisfeld Milano Luciana da Silva Timossi Ana Claudia Vecchi Osiecki Raul Osiecki Lupe Furtado Alle 《Genetics and molecular biology》2014,37(3):490-495
In this study, we investigated the influence of two SNPs (rs846910 and rs12086634) of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1), the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of both sexes from southern Brazil. The HSD11B1 gene variants were genotyped using the TaqMan SNP genotyping assay. Glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were measured by standard automated methods. Significant results were found in women, with carriers of the G allele of SNP rs12086634 having higher glucose levels than non-carriers. Carriers of the A allele of SNP rs846910 had higher levels of HDL-cholesterol. The involvement of both polymorphisms as independent factors in determining the levels of glucose and HDL-cholesterol was confirmed by multiple regression analysis (β = 0.19 ±0.09, p = 0.03 and β= 0.22 ± 0.10, p = 0.03, respectively). Our findings suggest that the HSD11B1SNPs studied may indirectly influence glucose and HDL-cholesterol metabolism in women, possibly through down-regulation of the HSD11B1 gene by estrogen. 相似文献
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Jovana Jasnic-Savovic Sabine Krause Slobodan Savic Ana Kojic Vlado Kovcic Srdjan Boskovic Aleksandra Nestorovic Ljiljana Rakicevic Olivia Schreiber-Katz Johannes G. Vogel Benedikt G. Schoser Maggie C. Walter Giorgio Valle Dragica Radojkovic Georgine Faulkner Snezana Kojic 《Histochemistry and cell biology》2016,146(5):569-584
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The effects of hemicelluloses and lignin removal on water uptake behavior of hemp fibers 总被引:1,自引:0,他引:1
This study investigated the individual influences of hemicelluloses and lignin removal on the water uptake behavior of hemp fibers. Hemp fibers with different content of either hemicelluloses or lignin were obtained by chemical treatment with 17.5% sodium hydroxide or 0.7% sodium chlorite. Various tests (capillary rise method, moisture sorption, water retention power) were applied to evaluate the change in water uptake of modified hemp fibers. The obtained results show that when the content of either hemicelluloses or lignin is reduced progressively by chemical treatment, the capillary properties of hemp fibers are improved, i.e. capillary rise height of modified fibers is increased up to 2.7 times in relation to unmodified fibers. Furthermore, hemicelluloses removal increases the moisture sorption and decreases the water retention values of hemp fibers, while lignin removal decreases the moisture sorption and increases the water retention ability of hemp fibers. 相似文献
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Adrijana Z. Burmudžija Jovana M. Muškinja Marijana M. Kosanić Branislav R. Ranković Slađana B. Novaković Snežana B. Đorđević Tatjana P. Stanojković Dejan D. Baskić Zoran R. Ratković 《化学与生物多样性》2017,14(8)
A small series of 1‐acetyl‐2‐(4‐alkoxy‐3‐methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐buten‐2‐one) and its O‐alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 μm ), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 μm , respectively). 相似文献
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Jovana Kovacevic Carolina Arguedas-Villa Anna Wozniak Taurai Tasara Kevin J. Allen 《Applied and environmental microbiology》2013,79(6):1915-1922
Listeria monocytogenes strains belonging to serotypes 1/2a and 4b are frequently linked to listeriosis. While inlA mutations leading to premature stop codons (PMSCs) and attenuated virulence are common in 1/2a, they are rare in serotype 4b. We observed PMSCs in 35% of L. monocytogenes isolates (n = 54) recovered from the British Columbia food supply, including serotypes 1/2a (30%), 1/2c (100%), and 3a (100%), and a 3-codon deletion (amino acid positions 738 to 740) seen in 57% of 4b isolates from fish-processing facilities. Caco-2 invasion assays showed that two isolates with the deletion were significantly more invasive than EGD-SmR (P < 0.0001) and were either as (FF19-1) or more (FE13-1) invasive than a clinical control strain (08-5578) (P = 0.006). To examine whether serotype 1/2a was more likely to acquire mutations than other serotypes, strains were plated on agar with rifampin, revealing 4b isolates to be significantly more mutable than 1/2a, 1/2c, and 3a serotypes (P = 0.0002). We also examined the ability of 33 strains to adapt to cold temperature following a downshift from 37°C to 4°C. Overall, three distinct cold-adapting groups (CAG) were observed: 46% were fast (<70 h), 39% were intermediate (70 to 200 h), and 15% were slow (>200 h) adaptors. Intermediate CAG strains (70%) more frequently possessed inlA PMSCs than did fast (20%) and slow (10%) CAGs; in contrast, 87% of fast adaptors lacked inlA PMSCs. In conclusion, we report food chain-derived 1/2a and 4b serotypes with a 3-codon deletion possessing invasive behavior and the novel association of inlA genotypes encoding a full-length InlA with fast cold-adaptation phenotypes. 相似文献
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Velimir Popsavin Jovana Francuz Bojana Srećo Zelenović Goran Benedeković Mirjana Popsavin Vesna Kojić Gordana Bogdanović 《Bioorganic & medicinal chemistry letters》2013,23(20):5507-5510
Cytotoxic (+)-goniofufurone mimic such as benzoxepane 2 was preferentially formed after the treatment of 7-O-benzoyl-5-O-benzyl (+)-goniofufurone derivative 6 with titanium(IV) fluoride. However, the corresponding 7-epimer 5 (derivative of 7-epi-goniofufurone) under the similar reaction conditions gave mainly 7-deoxy derivative 7 as a result of an unexpected 1,5-hydride shift. Extension of this methodology to the enantiomer ent-6 provided cytotoxic (?)-goniofufurone mimics ent-2 and ent-7. Synthesized compounds showed diverse growth inhibitory effects against selected tumour cell lines, but were devoid of any significant toxicity towards the normal foetal lung fibroblasts (MRC-5). A SAR study reveals the structural features of these lactones that are beneficial for their antiproliferative activity, such as presence of an additional oxepane ring, the absolute stereochemistry and the presence of a deoxy function at the C-7 position. 相似文献
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Jovana J. Ajduković Evgenija A. Djurendić Edward T. Petri Olivera R. Klisurić Andjelka S. Ćelić Marija N. Sakač Dimitar S. Jakimov Katarina M. Penov Gaši 《Bioorganic & medicinal chemistry》2013,21(23):7257-7266
We report a rapid and efficient synthesis of A-ring modified 17α-picolyl and 17(E)-picolinylidene androstane derivatives from dehydroepiandrosterone. Compounds were validated spectroscopically and structurally characterized by X-ray crystallography. Virtual screening by molecular docking against clinical targets of steroidal anticancer drugs (ERα, AR, Aromatase and CYP17A1) suggests that 17(E)-picolinylidene, but not 17α-picolyl androstanes could specifically interact with CYP17A1 (17α-hydroxylase) with similar geometry and affinity as Abiraterone, a 17-pyridinyl androstane drug clinically used in the treatment of prostate cancer. In addition, several 17(E)-picolinylidene androstanes demonstrated selective antiproliferative activity against PC3 prostate cancer cells, which correlates with Abiraterone antiproliferative activity and predicted CYP17A1 binding affinities. Based on these preliminary results, 17(E)-picolinylidene androstane derivatives could be a promising starting point for the development of new compounds for the treatment of prostate cancer. 相似文献
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Gordana M Pavlović-Lažetić Nenad S Mitić Jovana J Kovačević Zoran Obradović Saša N Malkov Miloš V Beljanski 《BMC bioinformatics》2011,12(1):66