全文获取类型
收费全文 | 365篇 |
免费 | 21篇 |
专业分类
386篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 9篇 |
2019年 | 4篇 |
2018年 | 3篇 |
2017年 | 7篇 |
2016年 | 15篇 |
2015年 | 13篇 |
2014年 | 13篇 |
2013年 | 16篇 |
2012年 | 23篇 |
2011年 | 14篇 |
2010年 | 10篇 |
2009年 | 14篇 |
2008年 | 22篇 |
2007年 | 15篇 |
2006年 | 16篇 |
2005年 | 20篇 |
2004年 | 25篇 |
2003年 | 19篇 |
2002年 | 11篇 |
2001年 | 3篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 9篇 |
1997年 | 11篇 |
1996年 | 6篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 6篇 |
1992年 | 8篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1977年 | 2篇 |
1973年 | 1篇 |
1972年 | 4篇 |
1970年 | 2篇 |
1968年 | 3篇 |
1967年 | 2篇 |
排序方式: 共有386条查询结果,搜索用时 15 毫秒
151.
Audrey Goldner-Sauvé Claude Szpirer Josiane Szpirer Goran Levan David L. Gasser 《Biochemical genetics》1991,29(5-6):275-286
We have utilized rat-mouse somatic cell hybrids to make chromosomal assignments for the glucocorticoid receptor (GR), myelin basic protein (MBP), leukocyte common antigen (LCA), and testosterone-repressed prostate message-2 (TRPM2) genes in the rat. The genes for GR and MBP both map on chromosome 18 of the rat, which corresponds to the mapping of both genes on chromosome 18 of the mouse. The gene for LCA maps on chromosome 13, which is where C4b-binding protein -chain (C4BPB), coagulation factor V (F5), and renin have previously been assigned. This linkage group appears to be homologous to a substantial portion of mouse chromosome 1 and human chromosome 1q. Finally, the TRPM2 gene has been assigned to rat chromosome 15.This project was supported by Grants RG 1877-A-1 from the National Multiple Sclerosis Society and P50 DE09164 from the NIH, by grants from the Swedish Cancer Society, the Erik Philip-Sörensen Foundation, the Trygger Foundation, the IngaBritt and Arne Lundberg Research Foundation, CANCIRCO, and BioVast (Gothenbrug), by the Belgian program on Interuniversity Attraction Poles initiated by the Belgian State-Prime Minister's Office-Science Policy Programming, and by a grant from the CGER-ASLK (Brussels). C.S. is a Senior Research Associate of the National Fund for Scientific Research (FNRS, Belgium). 相似文献
152.
Cécile Vassort Michèle Rivière Gilles Bruneau François Gros Jean Thibault Göran Levan Josiane Szpirer Claude Szpirer 《Mammalian genome》1993,4(4):202-206
By use of rat cDNA probes and a panel of cell hybrids segregating rat chromosomes, the genes encoding three pyridoxal 5-phosphate (PLP)-dependent decarboxylases—namely, DOPA-decarboxylase (Ddc), glutamic acid decarboxylase 1 and 2 (Gad1 and Gad2)—were assigned to rat Chromosomes (Chrs) 14, 3, and 17, respectively. If one takes into account chromosome localizations in the human and the mouse, the present results (i) show that a synteny group is retained on rat Chr 14, human Chr 7, and mouse Chr 11 (Ddc); (ii) strengthen the homology relation known between rat Chr 3 and human and mouse Chrs 2 (Gad1); (iii) suggest that rat Chr 17 has no extensive homology to any human chromosome; and (iv) suggest the order (Prl, Fdp)-Tpl2-Gad2 on the rat Chr 17. 相似文献
153.
Estelle Thauvin Michelle Fusselier Josiane Arnaud Henri Faure Max Favier Charles Coudray Marie-Jeanne Richard Alain Favier 《Biological trace element research》1992,32(1-3):405-414
The effect of a multivitamin-mineral supplement was investigated during pregnancy according to a double-blind protocol by
determining zinc and copper in maternal plasma, mononuclear and polynuclear zinc and copper at the third, sixth, eighth, and
ninth months of gestation. The subjects were supplemented from the first trimester until delivery. A significant decrease
was observed in plasma zinc that varied from 11.5 μmol/L to 10.8 μmol/L in the supplemented group (n=29) and from 11 μmol/L to 10 μmol/L in the placebo group (n=33) at 3 and 9 mo of gestation, respectively. In contrast, plasma copper levels increased in a way depending upon the stage
of gestation in both groups: from 24.7 to 28.2 μmol/L in the treated group and from 24.9 to 30.9 μmol/L in the placebo group
at 3 and 9 mo of gestation, respectively, but the difference was only significant in the placebo group. No difference between
groups was observed in mononuclear and polynuclear zinc or copper levels.
These trace elements were also determined in cord blood at delivery. There were no statistically significant differences in
zinc and copper concentration found in placebo group and supplemented group. Finally, the beneficial effect of supplementation
on muscular cramps and appearance of vergetures was noted. 相似文献
154.
155.
156.
157.
Amplification of thec-erbB2gene and overexpression of p185erbB2is found in approximately one-third of primary breast and ovarian cancers and also in some colon carcinomas. Moreover, a single point mutation inerbB2(V 664 E)confers transforming potential to erbB2 in NIH3T3 cells, even when expressed at low levels. To examine the transformation potential oferbB2orerbB2(V-E)in colon epithelial cells, we have transfected a nontumorigenic clone of SW 613-S cells with either wild-type p185erbB2or mutated p185erbB2(V-E). In contrast to p185erbB2, p185erbB2(V-E)associated constitutively with members of the Shc protein family, leading to phosphorylation of Shc and to stimulation of mitogen-activated protein kinase (MAP kinase). However, constitutive activation of MAP kinase activation in p185erbB2(V-E)expressing cells did not result in a tumorigenic phenotype. In addition, p185erbB2(V-E)expressing cells displayed a reduced ability to grow in soft agar compared to the parental cell line. In contrast these transfected cells were able to grow in three-dimensional collagen gels, whereas parental cells were not. Thus, expression oferbB2(V-E)in SW 613-S cells induced multiple changes in intracellular signaling and in growth requirement phenotype, particularly in response to the extracellular environment. 相似文献
158.
Véronique Blanc Patricia Gil Nathalie Bamas-Jacques Sophie Lorenzon Monique Zagorec Josiane Schleuniger Didier Bisch Francis Blanche Laurent Debussche Joe¨l Crouzet & Denis Thibaut 《Molecular microbiology》1997,23(2):191-202
Four pap genes ( papA , papB , papC , papM ) were found by sequencing near to snbA , a Streptomyces pristinaespiralis gene which was previously shown to encode one of the pristinamycin I (PI) synthetases. Analysis of the homologies observed from the deduced amino acid sequences suggested that these four genes could be involved in the biosynthesis of the PI precursor 4-dimethylamino- l -phenylalanine (DMPAPA). This was first verified when disruption of papA in S. pristinaespiralis led to a PI− phenotype, which was reversed by the addition of DMPAPA into the culture medium. Further confirmation was obtained when papM was overexpressed in Escherichia coli and the corresponding protein purified to homogeneity. It catalysed the two successive N -methylation steps of 4-amino- l -phenylalanine leading to DMPAPA via 4-methylamino- l -phenylalanine. These results allowed us to assign a function to each of the four pap genes and to propose a biosynthetic pathway for DMPAPA. 相似文献
159.
Josiane Aubert Bernard Barascud Henri Descimon Francois Miche 《Biological journal of the Linnean Society. Linnean Society of London》1997,60(4):467-492
The Corsican swallowtail butterfly, Papilio hospiton , is endemic to Corsica and Sardinia (France and Italy) and included in the list of endangered species by the Washington Convention, It is spread all over Corsica in scattered populations linked to diverse habitats. A study by enzyme electrophoresis showed that the genetic diversity of the species is of the same order of magnitude as that of Papilio machaon from continental France and Corsica. The differentiation between populations is rather low, which is consistent with the high vagility of the adults. Natural hybridization between P. hospiton and P. machaon is frequent, and laboratory crosses show that the hybrids are not sterile. However, developmental perturbations impair the viability of further hybrid progenies. Although limited introgression between the two species is likely to take place, enzyme electrophoresis and PCR-RFLP analysis of mitochondrial DNA show that their gene pools remain distincfTtienetic assimilation by P. machaon therefore does not seem to be a threat for P. hospiton. 相似文献
160.
Josiane Feutrier Michèle Lepelletier Marie-Claire Pascal Marc Chippaux 《Molecular & general genetics : MGG》1982,185(3):518-519
Summary Tn10 transposons were intergrated near ser C at 20 units on the chromosomal map of E. coli; pep N was mapped close to ser C between this gene and pyr D, one minute away from its previously assumed position. 相似文献