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Parvinderdeep S. Kahlon Shallet Mindih Seta Gesche Zander Daniela Scheikl Ralph Hückelhoven Matthieu H. A. J. Joosten Remco Stam 《Proceedings. Biological sciences / The Royal Society》2020,287(1941)
Natural plant populations encounter strong pathogen pressure and defence-associated genes are known to be under selection dependent on the pressure by the pathogens. Here, we use populations of the wild tomato Solanum chilense to investigate natural resistance against Cladosporium fulvum, a well-known ascomycete pathogen of domesticated tomatoes. Host populations used are from distinct geographical origins and share a defined evolutionary history. We show that distinct populations of S. chilense differ in resistance against the pathogen. Screening for major resistance gene-mediated pathogen recognition throughout the whole species showed clear geographical differences between populations and complete loss of pathogen recognition in the south of the species range. In addition, we observed high complexity in a homologues of Cladosporium resistance (Hcr) locus, underlying the recognition of C. fulvum, in central and northern populations. Our findings show that major gene-mediated recognition specificity is diverse in a natural plant-pathosystem. We place major gene resistance in a geographical context that also defined the evolutionary history of that species. Data suggest that the underlying loci are more complex than previously anticipated, with small-scale gene recombination being possibly responsible for maintaining balanced polymorphisms in the populations that experience pathogen pressure. 相似文献
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P.C. Maris N.N. Joosten R.W. Goldbach & D. Peters 《Entomologia Experimentalis et Applicata》2004,113(3):149-155
The effect of thrips resistance in pepper (Capsicum annuum L.) – previously shown to result in impeded thrips population development (Maris PC, Joosten NN, Goldbach RW & Peters D (2003a) Restricted spread of Tomato spotted wilt virus in thrips‐resistant pepper. Phytopathology 93: 1223–1227. Maris PC, Joosten NN, Goldbach RW & Peters D (2003b) Spread of Tomato spotted wilt virus and population development of Frankliniella occidentalis in pepper resistant to thrips. Proceedings of the Section Experimental and Applied Entomology Netherlands Entomological Society (NEV) Amsterdam 14: 95–101.) – on thrips’[Frankliniella occidentalis Pergande (Thysanoptera: Thripidae)] reproduction, mortality, host preference, and behaviour was investigated. Reproduction, studied by oviposition and larval survival, was negatively affected by the thrips‐resistant (TR) phenotype, whereas the offspring's developmental rate did not differ on TR and the thrips‐susceptible (TS) phenotype. While thrips’ behaviour was hardly affected by thrips resistance, a significant preference for TS plants over the TR plants was found in different tests. When released on either a TR or a TS plant, thrips dispersed at significantly higher rates from the TR plants, demonstrating that not only an impeded reproduction, but also a reduced residence time adds to the reported lower thrips numbers on TR plants. 相似文献
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C. S. Horjus Talabur Horje R. Bruijnen L. Roovers M. J. M. Groenen F. B. M. Joosten P. J. Wahab 《PloS one》2015,10(8)
Background and Aims
To prospectively examine the feasibility and accuracy of Contrast Enhanced Ultrasound (CEUS) in the assessment of Crohn’s disease (CD) activity in the terminal ileum in comparison to Magnetic Resonance Enterography (MRE), using endoscopy as a reference standard.Methods
105 consecutive patients with alleged clinically active CD were assessed by MRE and CEUS. CEUS of the terminal ileum was performed using an intravenous microbubble contrast enhancer. Accuracy values of CEUS and MRE for the presence of active terminal ileitis were evaluated using the Receiver Operating Characteristic method, using endoscopic findings as a reference standard. Sensitivity and specificity values of MRE and CEUS were compared by the McNemar test.Results
CEUS was feasible in 98% of patients, MRE in all. Optimal diagnostic accuracy in CEUS was obtained at a peak intensity value of 10%, showing 100% sensitivity, 92% specificity and an accuracy of 99% in demonstrating ileal mucosal inflammation. For MRE, overall sensitivity, specificity and accuracy were, 87%, 100%, and 88%, respectively. CEUS and MRE were highly correlated in assessing length and wall thickness of the terminal ileum. CEUS identified 11 of 16 MRE-detected strictures, but no fistulae.Conclusion
The accuracy of CEUS is comparable to that of MRE in the assessment of active, uncomplicated terminal ileal CD and therefore a valuable bedside alternative to MRE in the follow-up of these patients. 相似文献69.
Locomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury 总被引:1,自引:0,他引:1
Injury to the spinal cord (SCI) can produce a constellation of problems including chronic pain, autonomic dysreflexia, and motor dysfunction. Neuroplasticity in the form of fiber sprouting or the lack thereof is an important phenomenon that can contribute to the deleterious effects of SCI. Aberrant sprouting of primary afferent fibers and synaptogenesis within incorrect dorsal horn laminae leads to the development and maintenance of chronic pain as well as autonomic dysreflexia. At the same time, interruption of connections between supraspinal motor control centers and spinal cord output cells, due to lack of successful regenerative sprouting of injured descending fiber tracts, contributes to motor deficits. Similarities in the molecular control of axonal growth of motor and sensory fibers have made the development of cogent therapies difficult. In this study, we discuss recent findings related to the degradation of inhibitory barriers and promotion of sprouting of motor fibers as a strategy for the restoration of motor function and note that this may induce primary afferent fiber sprouting that can contribute to chronic pain. We highlight the importance of careful attentiveness to off-target molecular- and circuit-level modulation of nociceptive processing while moving forward with the development of therapies that will restore motor function after SCI. 相似文献
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Balancing selection favors guarding resistance proteins 总被引:13,自引:0,他引:13
The co-evolutionary arms race model for plant-pathogen interactions implies that resistance (R) genes are relatively young and monomorphic. However, recent reports show R gene longevity and co-existence of multiple R genes in natural populations. This indicates that R genes are maintained by balancing selection, which occurs when loss of the matching avirulence (Avr) gene in the pathogen is associated with reduced virulence. We reason that balancing selection favors R proteins that function as guards, monitoring changes in the virulence target mediated by the Avr factor, rather than recognizing the Avr factor itself. Indeed, the available experimental data support the notion that guarding is prevalent in gene-for-gene interactions. 相似文献