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El Achi Hanadi Awwad Johnny Abou Daya Sarah Halabi Sahar Damianos Sandra Mahfouz Rami 《Molecular biology reports》2018,45(5):911-916
Molecular Biology Reports - Recurrent pregnancy loss (RPL) is a problem affecting up to 5% of women of childbearing age due to many factors. Studies have shown that RPL and cardiovascular disease... 相似文献
115.
Philippe Gourlet Andre Vandermeers Pascale Vertongen Jean Rathe Philippe de Neef Johnny Cnudde Magali Waelbroeck Patrick Robberecht 《Peptides》1997,18(10):1539-1545
Gourlet, P., A. Vandermeers, P. Vertongen, J. Rathe, P. De Neef, J. Cnudde, M. Waelbroeck and P. Robberecht. Development of high affinity selective VIP1 receptor agonists. Peptides 18(10) 1539–1545, 1997.—The biological effects of VIP are mediated by at least two VIP receptors: the VIP1 and the VIP2 receptors that were cloned in rat, human and mice. As the mRNA coding for each receptor are located in different tissues, it is likely that each receptor modulates different functions. It is therefore of interest to obtain selective agonists for each receptor subtype. In the present work, we achieved the synthesis of two VIP1 receptor selective agonists derived from secretin and GRF. [R16]chicken secretin had IC50 values of binding of 1, 10,000, 20, and 3000 nM for the rat VIP1-, VIP2-, secretin- and PACAP receptors, respectively. This peptide, however, had a weaker affinity for the human VIP1 receptor (IC50 of 60 nM). The chimeric, substituted peptide [K15,R16,L27]VIP(1-7)/GRF(8-27) had IC50 values of binding of 1, 10,000, 10,000 and 30,000 nM for the rat VIP1-, VIP2-, secretin- and PACAP receptors, respectively. Furthermore, its also showed an IC50 of 0.8 nM for the human VIP1 receptor and a low affinity for the human VIP2 receptor. It is unlikely that this GRF analogue interacted with a high affinity to the pituitary GRF receptors as it did not stimulate rat pituitary adenylate cyclase activity. The two described analogues stimulated maximally the adenylate cyclase activity on membranes expressing each receptor subtype. 相似文献
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Eva A. Andersson Johnny Nilsson Zhijia Ma Alf Thorstensson 《European journal of applied physiology and occupational physiology》1997,75(2):115-123
The purpose of this study was to provide objective information on the involvement of different abdominal and hip flexor muscles
during various types of common training exercises used in rehabilitation and sport. Six healthy male subjects performed altogether
38 different static and dynamic training exercises – trunk and hip flexion sit-ups, with various combinations of leg position
and support, and bi- and unilateral leg lifts. Myoelectric activity was recorded with surface electrodes from the rectus abdominis,
obliquus externus, obliquus internus, rectus femoris, and sartorius muscles and with indwelling fine-wire electrodes from
the iliacus muscle. The mean electromyogram amplitude, normalised to the highest observed value, was compared between static
and dynamic exercises separately. The hip flexors were highly activated only in exercises involving hip flexion, either lifting
the whole upper body or the legs. In contrast, the abdominal muscles showed marked activation both during trunk and hip flexion
sit-ups. In hip flexion sit-ups, flexed and supported legs increased hip flexor activation, whereas such modifications did
not generally alter the activation level of the abdominals. Bilateral, but not unilateral, leg lifts required activation of
abdominal muscles. In trunk flexion sit-ups an increased activation of the abdominal muscles was observed with increased flexion
angle, whereas the opposite was true for hip flexion sit-ups. Bilateral leg lifts resulted in higher activity levels than
hip flexion sit-ups for the iliacus and sartorius muscles, while the opposite was true for rectus femoris muscles. These data
could serve as a basis for improving the design and specificity of test and training exercises.
Accepted: 12 August 1996 相似文献
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Katja Maretty-Kongstad Ninna Aggerholm-Pedersen Johnny Keller Akmal Safwat 《Translational oncology》2017,10(6):942-948
BACKGROUND: The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) adjusted for confounders. METHODS: The study included 818 patients with localized STS. Pretreatment levels of albumin, C-reactive protein, hemoglobin, neutrophils, and lymphocytes were tested individually and combined in prognostic scores: neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), and Aarhus Composite Biomarker Score (ACBS) which includes all five biomarkers. Patients were randomly split into a test cohort and a validation cohort. The prognostic value of biomarkers on DSS was estimated using crude and adjusted Cox proportional hazard models. The different biomarker scores were compared using Akaike's information criteria. RESULTS: In the test cohort of 403 patients, all biomarkers except lymphocyte count were significant prognostic factors for DSS also after adjusting for confounders. NLR, GPS, and ACBS were independently associated with decreased survival; however, ACBS was significantly superior to NLR (P = .02) and GPS (P = .002). These findings were validated in the randomly assigned validation cohort of 415 patients. In the pooled data of 818 patients, the ACBS performed better than GPS and NLR. ACBS 2 was independently associated with decreased DSS compared to ACBS 0, hazard ratio 2.3[95% confidence interval: 1.5-3.5], P < .001. CONCLUSION: Patients with abnormal values in more than one serum biomarkers had a significant additional risk of dying compared to patients with only one abnormal value. ACBS was validated as an independent prognostic factor that is superior to both NLR and GPS. 相似文献
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Andrew M Ho Paul C Marker Hairong Peng Andres J Quintero David M Kingsley Johnny Huard 《BMC developmental biology》2008,8(1):35
Background
Over a hundred years ago, Wolff originally observed that bone growth and remodeling are exquisitely sensitive to mechanical forces acting on the skeleton. Clinical studies have noted that the size and the strength of bone increase with weight bearing and muscular activity and decrease with bed rest and disuse. Although the processes of mechanotransduction and functional response of bone to mechanical strain have been extensively studied, the molecular signaling mechanisms that mediate the response of bone cells to mechanical stimulation remain unclear. 相似文献120.
Siu T Li Y Nagasawa J Liang J Tehrani L Chua P Jones RE Defeo-Jones D Barnett SF Robinson RG 《Bioorganic & medicinal chemistry letters》2008,18(14):4191-4194
This letter details the attenuation of hERG in a class of Akt inhibitors through heteroatom insertions into aromatic rings. The development of a cell-active dual Akt 1 and 2 inhibitors devoid of hERG activity is discussed using structure–activity relationships. 相似文献