全文获取类型
收费全文 | 190篇 |
免费 | 15篇 |
专业分类
205篇 |
出版年
2022年 | 6篇 |
2021年 | 6篇 |
2020年 | 4篇 |
2019年 | 4篇 |
2018年 | 6篇 |
2017年 | 4篇 |
2016年 | 4篇 |
2015年 | 5篇 |
2014年 | 5篇 |
2013年 | 5篇 |
2012年 | 16篇 |
2011年 | 9篇 |
2010年 | 12篇 |
2009年 | 2篇 |
2008年 | 5篇 |
2007年 | 5篇 |
2006年 | 6篇 |
2005年 | 4篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 3篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1999年 | 1篇 |
1998年 | 4篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1973年 | 2篇 |
1969年 | 1篇 |
1967年 | 4篇 |
1966年 | 1篇 |
排序方式: 共有205条查询结果,搜索用时 0 毫秒
201.
Inês Carqueijeiro Konstantinos Koudounas Thomas Dug de Bernonville Liuda Johana Sepúlveda Angela Mosquera Dikki Pedenla Bomzan Audrey Oudin Arnaud Lanoue Sbastien Besseau Pamela Lemos Cruz Natalja Kulagina Emily A Stander Sbastien Eymieux Julien Burlaud-Gaillard Emmanuelle Blanchard Marc Clastre Lucia Atehorta Benoit St-Pierre Nathalie Giglioli-Guivarch Nicolas Papon Dinesh A Nagegowda Sarah E OConnor Vincent Courdavault 《Plant physiology》2021,185(3):836
202.
203.
Mikhail Schepetilnikov Lyubov A Ryabova Mikhail Schepetilnikov Joelle Makarian Ola Srour Angèle Geldreich Zhenbiao Yang Johana Chicher Philippe Hammann Lyubov A Ryabova 《The EMBO journal》2017,36(7):886-903
Target of rapamycin (TOR) promotes reinitiation at upstream ORFs (uORFs) in genes that play important roles in stem cell regulation and organogenesis in plants. Here, we report that the small GTPase ROP2, if activated by the phytohormone auxin, promotes activation of TOR, and thus translation reinitiation of uORF-containing mRNAs. Plants with high levels of active ROP2, including those expressing constitutively active ROP2 (CA-ROP2), contain high levels of active TOR. ROP2 physically interacts with and, when GTP-bound, activates TOR in vitro. TOR activation in response to auxin is abolished in ROP-deficient rop2 rop6 ROP4 RNAi plants. GFP-TOR can associate with endosome-like structures in ROP2-overexpressing plants, indicating that endosomes mediate ROP2 effects on TOR activation. CA-ROP2 is efficient in loading uORF-containing mRNAs onto polysomes and stimulates translation in protoplasts, and both processes are sensitive to TOR inhibitor AZD-8055. TOR inactivation abolishes ROP2 regulation of translation reinitiation, but not its effects on cytoskeleton or intracellular trafficking. These findings imply a mode of translation control whereby, as an upstream effector of TOR, ROP2 coordinates TOR function in translation reinitiation pathways in response to auxin. 相似文献
204.
205.
Gabrielle Haas Semih Cetin Mélanie Messmer Béatrice Chane-Woon-Ming Olivier Terenzi Johana Chicher Lauriane Kuhn Philippe Hammann Sébastien Pfeffer 《Nucleic acids research》2016,44(6):2873-2887
The mechanism by which micro (mi)RNAs control their target gene expression is now well understood. It is however less clear how the level of miRNAs themselves is regulated. Under specific conditions, abundant and highly complementary target RNA can trigger miRNA degradation by a mechanism involving nucleotide addition and exonucleolytic degradation. One such mechanism has been previously observed to occur naturally during viral infection. To date, the molecular details of this phenomenon are not known. We report here that both the degree of complementarity and the ratio of miRNA/target abundance are crucial for the efficient decay of the small RNA. Using a proteomic approach based on the transfection of biotinylated antimiRNA oligonucleotides, we set to identify the factors involved in target-mediated miRNA degradation. Among the retrieved proteins, we identified members of the RNA-induced silencing complex, but also RNA modifying and degradation enzymes. We further validate and characterize the importance of one of these, the Perlman Syndrome 3′-5′ exonuclease DIS3L2. We show that this protein interacts with Argonaute 2 and functionally validate its role in target-directed miRNA degradation both by artificial targets and in the context of mouse cytomegalovirus infection. 相似文献