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181.
Carlos Gustavo Vasconcelos de Moraes Antonio Carlos Facio Jr. José Humberto Costa Roberto Freire Santiago Malta 《Journal of ocular biology, diseases, and informatics》2009,2(1):40-46
The purpose of this study was to describe the surgical outcomes and safety of intracameral bevacizumab during trabeculectomy in eyes with neovascular glaucoma. Pilot study included four eyes (four patients) with refractory neovascular glaucoma submitted to fornix-based trabeculectomy with adjunctive use of bevacizumab in the anterior chamber during the procedure. Patients were previously treated with panretinal photocoagulation as standard therapy. Variables evaluated were intraocular pressure, bleb appearance, iris neovascularization, intraoperative/postoperative complications, and visual outcomes. No intraoperative complication was observed. The mean follow-up period was 12.75 (range, 12–15 months). All eyes showed significant intraocular pressure control postoperatively. Iris neovascularization reduced significantly within 1 month after surgery. Mild anterior chamber inflammation was observed during follow-up in all eyes. No significant postoperative complication was observed, and no patient presented visual acuity deterioration. Intracameral bevacizumab may be used as an adjunctive therapy during trabeculectomy in eyes with neovascular glaucoma. 相似文献
182.
Joana RF Abreu Daphne de Launay Marjolein E Sanders Aleksander M Grabiec G Marleen van de Sande Paul P Tak Kris A Reedquist 《Arthritis research & therapy》2009,11(4):R121-13
Introduction
Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients share many similarities with transformed cancer cells, including spontaneous production of matrix metalloproteinases (MMPs). Altered or chronic activation of proto-oncogenic Ras family GTPases is thought to contribute to inflammation and joint destruction in RA, and abrogation of Ras family signaling is therapeutic in animal models of RA. Recently, expression and post-translational modification of Ras guanine nucleotide releasing factor 1 (RasGRF1) was found to contribute to spontaneous MMP production in melanoma cancer cells. Here, we examine the potential relationship between RasGRF1 expression and MMP production in RA, reactive arthritis, and inflammatory osteoarthritis synovial tissue and FLS. 相似文献183.
184.
185.
Romain Duroux Nicolas Renault Joana Esteves Cuelho Laurence Agouridas David Blum Luisa V. Lopes 《Journal of enzyme inhibition and medicinal chemistry》2017,32(1):850-864
The development of adenosine A2A receptor antagonists has received much interest in recent years for the treatment of neurodegenerative diseases. Based on docking studies, a new series of 2-arylbenzoxazoles has been identified as potential A2AR antagonists. Structure-affinity relationship was investigated in position 2, 5 and 6 of the benzoxazole heterocycle leading to compounds with a micromolar affinity towards the A2A receptor. Compound F1, with an affinity of 1?μm, presented good absorption, distribution, metabolism and excretion properties with an excellent aqueous solubility (184?μm) without being cytotoxic at 100?μm. This compound, along with low-molecular weight compound D1 (Ki?=?10?μm), can be easily modulated and thus considered as relevant starting points for further hit-to-lead optimisation. 相似文献
186.
Tatiane A. Paixão Marcelo C. C. Malta Semíramis A. Soave Herlandes P. Tinoco Maria E.L.T. Costa Angela T. Pessanha Rodrigo O.S. Silva Fernanda M. Coura Luciana F. Costa Andreia P. Turchetti Francisco C.F. Lobato Marilia M. Melo Marcos B. Heinemann Renato L. Santos 《Journal of medical primatology》2014,43(2):118-121
187.
Joana Barbosa Acácio Gon?alves Rodrigues Maria José Pérez Cidália Pina-Vaz 《Memórias do Instituto Oswaldo Cruz》2014,109(8):1078-1080
Giardia duodenalis (syn. lamblia; syn.
intestinalis) susceptibility testing is not routinely performed because
the classical culture methods are very time-consuming and laborious. We developed
a novel flow cytometry (FC) assay to evaluate the susceptibility of G.
duodenalis trophozoites to metronidazole (MTZ). Different concentrations of
MTZ were added to cultures of trophozoites (10
5
/mL) and the cultures were incubated for different periods. The 50%
inhibitory concentration was calculated and propidium iodide (PI) was used to
quantify the number of dead cells. After treatment, PI-positive trophozoites
increased with increasing drug concentration and exposure time. An excellent
correlation was found between FC and the classical method. A novel, accurate and
reliable method is now available to evaluate G. duodenalis
viability. 相似文献
188.
189.
Golowczyc MA Gerez CL Silva J Abraham AG De Antoni GL Teixeira P 《Biotechnology letters》2011,33(4):681-686
Survival of two Lactobacillus kefir strains after spray drying in reconstituted skim milk with or without the addition of 12.5 g monosodium glutamate/l, 20 g
sucrose/l, or 20 g fructo-oligosaccharides (FOS)/l and during subsequent storage under different conditions of temperature
(20 and 30°C) and relative humidity (RH) (0, 11 and 23%) was evaluated. After being dried, L. kefir 8321 and L. kefir 8348 had a decrease in viability of 0.29 and 0.70 log cfu/ml respectively, while the addition of different protectants improved
the survival of both strains significantly. During storage, bacterial survival was significantly higher under lower conditions
of RH (0–11%), and monosodium glutamate and FOS proved to be the best protectants. 相似文献
190.
Beatriz Candida Silva Eldamária de Vargas Wolfgramm Vitor Resende da Costa Aguiar Frederico Scott Varela Malta Amanda Mafia de Castro Alessandro Clayton de Souza Ferreira Flavia de Paula Iúri Drumond Louro 《Molecular biology reports》2011,38(5):3013-3016
Allelic frequencies and other population data analysis are reported for the 15 autosomal Short Tandem Repeats (STR) loci included in the PowerPlex®16 kit (CSF1PO, D13S317, D16S539, D18S51, D21S11, D3S1358, D5S818, D7S820, D8S1179, FGA, Penta D, Penta E, TPOX, TH01 and vWA) in Pomeranian’s descendants from the Espirito Santo State (ES), Brazil, third largest population of Pomeranian’s descendants in the world. They chose the mountain region of the state for their preferred geographic location, and they have a very peculiar lifestyle with a selective mating behavior which has maintained their characteristics as a relatively pure subpopulation. Blood samples were obtained from 82 unrelated volunteers from 11 different cities of Espirito Santo State, where there are the Pomeranian’s descendants. All 15 loci analyzed showed Power of Discrimination (PD) values > 0.75. Except the TPOX locus, all analyzed loci were at Hardy–Weinberg equilibrium. This subpopulation has not yet been characterized for STR allelic frequencies used for forensic and genetic identification studies. 相似文献