全文获取类型
收费全文 | 103475篇 |
免费 | 3523篇 |
国内免费 | 1576篇 |
出版年
2022年 | 610篇 |
2021年 | 1160篇 |
2020年 | 807篇 |
2019年 | 951篇 |
2018年 | 1787篇 |
2017年 | 1731篇 |
2016年 | 3705篇 |
2015年 | 7386篇 |
2014年 | 7250篇 |
2013年 | 7119篇 |
2012年 | 6475篇 |
2011年 | 3590篇 |
2010年 | 3068篇 |
2009年 | 2944篇 |
2008年 | 1590篇 |
2007年 | 1419篇 |
2006年 | 1318篇 |
2005年 | 7273篇 |
2004年 | 5813篇 |
2003年 | 4009篇 |
2002年 | 1491篇 |
2001年 | 1393篇 |
2000年 | 629篇 |
1999年 | 1779篇 |
1998年 | 506篇 |
1992年 | 2074篇 |
1991年 | 2120篇 |
1990年 | 2177篇 |
1989年 | 2073篇 |
1988年 | 2004篇 |
1987年 | 1855篇 |
1986年 | 1657篇 |
1985年 | 1687篇 |
1984年 | 1103篇 |
1983年 | 847篇 |
1982年 | 473篇 |
1979年 | 1075篇 |
1978年 | 760篇 |
1977年 | 606篇 |
1976年 | 629篇 |
1975年 | 874篇 |
1974年 | 994篇 |
1973年 | 1005篇 |
1972年 | 953篇 |
1971年 | 928篇 |
1970年 | 820篇 |
1969年 | 830篇 |
1968年 | 734篇 |
1967年 | 751篇 |
1966年 | 585篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
V A Tronov V A Za?tsev D I Cherny? A N Koterov I V Filippovich 《Molekuliarnaia biologiia》1991,25(1):212-222
Binding of SSB-protein from Ehrlich ascites tumor to ssDNA from M13 phage leads to its compactization. The structure of the complex at the protein/DNA ratios far from the saturation level looks like "beads-on the string". DNA that was fully saturated with protein forms collapsed globular structure. Binding of the protein to the dsDNA from phage lambda increases its flexibility and decreases the coil dimensions; no "beads-on the string" structure are seen. The protein possess slight destabilizing effect on hairpin helices of M13DNA. Competition studies demonstrate that the binding properties of protein with polyribonucleotide lattices and DNA's decrease in ranking as follows: poly(rG) greater than or equal to poly(rI) greater than or equal to ssDNA greater than dsDNA greater than poly(rA) congruent to approximately poly(rU). Thus SSB-protein from Ehrlich ascites tumor differs significantly from its presumed prokaryotic analogs. 相似文献
942.
Steroidal saponins from the rhizomes of Polygonatum orientale. 总被引:6,自引:0,他引:6
943.
Y L Jiang G Massiot C Lavaud J M Teulon C Guéchot M Haag-Berrurier R Anton 《Phytochemistry》1991,30(7):2357-2360
Two new saponins were isolated from Mimosa tenuiflora and their structures established as 3-O-[alpha-L-rhamnopyranosyl(1----2)-beta-D-glucopyranosyl-(1----3]-(alp ha-L- arabinopyranosyl-(1----4]-beta-D-xylopyranosyl-(1----2)]-[beta-D- xylopyranosyl-(1----4)]-beta-D-glucopyranosyl)-28-O-alpha-L-rhamnopyrano syl oleanolic acid and 3-O-[alpha-L-rhamnopyranosyl-(1----2)-beta-D-glucopyranosyl-(1----3]-(al pha- L-arabinopyranosyl-(1----4]beta-D-xylopyranosyl-(1----2)]-[beta-D- xylopyranosyl-(1----4)]-beta-D-glucopyranosyl) oleanolic acid. 相似文献
944.
945.
T Kurzawiński L Ciesielski G Cie?lewicz 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1991,46(45-47):862-864
Phagocytic index and rosette test E have been determined in 50 patients, including 15 with diffuse peritonitis and the noncomplicated diffuse peritonitis, 20 patients with septic complications, and 15 patients who underwent abdominal surgery. It was found, that phagocytic index is decreased in all patients after abdominal surgery. The most marked decrease of this index was found in patients with complicated peritonitis. It still decreases in the course of peritonitis and increases in the reference group. The marked decrease in the number of T-cells was observed in complicated peritonitis during the whole period of follow-up while it normalizes in case of noncomplicated peritonitis as in the reference group. Using the tests under study it was possible to assess cell-mediated immunity which is depressed in peritonitis. The tests enable also the prediction of septic complications of peritonitis. 相似文献
946.
T Robak E Krykowski L Brodowski A Zawadzka-Bandura H Urbańska-Ry? M B?asińska-Morawiec W Matusewicz 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1991,46(48-49):931-934
An efficiency of the acute myeloblastic leukemia therapy has been assessed in 79 patients aged over 60 years. Twenty six patients out of this group have been treated with usual or reduced doses of doxorubicin and cytarabine (ADR-Ara-C) 35--low doses of cytarabine (LD Ara-C), 11-6-mercaptopurine (6 MP), and 7 patients died before chemotherapy. Complete remission in group treated with ADR-Ara-C was achieved in 23% of patients while partial remission in 42%. Median survival in this group was 5.8 months (range from 0.5 to 16 months). Percentage of the complete remissions in the group treated with LD-Ara-C was 6%, and partial remissions 40%. Median survival was 4.7 months (range from 0.5 to 14.2 months). Partial remission in 5 out of 11 patients treated with 6 MP (36%) and no complete remissions were noted. Median survival was 3.9 months. Therapy with ADR-Ara-C produced marked leucopenia and thrombocytopenia in the majority of treated patients. Vomiting, hemorrhagic complications, and bacterial infections have also been noted. These adverse reactions have been less frequent in patients treated with LD-Ara-C, and 6 MP. Ten patients (38%) treated with ADR-Ara-C and 7 patients treated with LD-Ara-C died during remission inducing therapy. 相似文献
947.
A Szyszka D Nowak A Ponizyński A Cie?liński Z Brocki 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1991,46(6-7):109-111
An average follow-up period of 16 patients was 28 months following an implantation of the artificial aortic valve for its insufficiency. In 10 operated patients who were able to continue their occupation exercise tolerance increased by two classes, according to NYHA. Blood pressure gradient decreased significantly from 61.8 to 37.5 mmHg, cardiac volume index decreased from 639 to 602 ml/m2. Echocardiographically measured muscle mass of the left ventricle, end-diastolic and end-systolic volumes, and the left atrial dimensions decreased significantly following surgery. A significance of the relation of the left ventricle volume to its mass <4 as a prognostic factor in aortic valve replacement has also been confirmed. 相似文献
948.
949.
J Fibak A J Onyszkiewicz K S?owiński W Burchardt J Kolasiński 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1991,46(45-47):869-871
Recurrence of duodenal ulcer was diagnosed in 15 patients who underwent highly selective vagotomy before 6-13 years, i.e. in 12.2%. Factors possibly contributing to such a recurrence were analysed. Patients with ulcer recurrence were: 1) non-qualified workers, 2) tobacco smokers, 3) heavy drinkers, 4) users of ulcerogenic medicines, and 5) were involved into conflict situations. 相似文献
950.
J C M?rkeberg H P Sheng R A Huggins 《Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)》1991,196(3):344-350
Use of 36Cl, 82Br, and [3H]sucrose to estimate extracellular water volume was evaluated in 14 piglets (7-14 days old). 36Cl and 82Br were distributed in approximately the same volume, but a period of 5-6 hr after injection was required to reach equilibrium in the neonatal pig. Dilution volumes calculated before equilibration (2-5 hr) for 36Cl (326 +/- 11 ml/kg) and 82Br (328 +/- 13 ml/kg) were different from equilibration (6-8 hr) phase volumes (356 +/- 13 ml/kg and 355 +/- 13 ml/kg, respectively; P less than 0.001). A 3-hr sample estimated the same volume distribution calculated by extrapolation of the 6- to 8-hr period because of the relationship between the two slopes of the plasma clearance curves. After the 82Br and 36Cl had achieved equilibration, each was distributed in a volume equivalent to total body chloride space (362 +/- 29 ml/kg) measured by neutron activation; no statistical differences were found (P = 0.6). The early equilibration phase measured a 10% smaller, faster exchangeable fraction of total body Cl. Sucrose dilution volume (332 +/- 19 ml/kg) required multiple plasma samples for extrapolation and measured a dilution volume 7% smaller (P less than 0.05) than total body chloride space. 相似文献