Unusual Formation of CoO@C “Dandelions” Derived from 2D Kagóme MOLs for Efficient Lithium Storage

Despite great breakthroughs, the search for anode materials with high performance for lithium‐ion batteries (LIBs) remains challenging. Hence, engineering advantageous structures via effective routes can bring new possibilities to the development of the LIB field. Herein, the precise synthesis of three‐dimensional (3D) hybrids of ultrathin carbon‐wrapped CoO (CoO@C) dandelions is reported by the pyrolysis of two‐dimensional (2D) Kagóme metal–organic layers (MOLs) at 400 °C under an Ar atmosphere. Due to the special coordination structure of the paternal MOLs, the resulting CoO nanowires show a small diameter of 5–10 nm and are uniformly confined within the ultrathin carbon layer. Based on the time‐dependent pyrolysis experiments, a crystal transformation mechanism of in situ self‐templated‐recrystallization‐self‐assembly accompanied by phase and morphology changes is first presented to reveal the formation of the 3D dandelion‐like spheres with assembly of nanowire arrays from a 2D Kagóme MOL. By virtue of structural and compositional features, including a 3D array structure, the small size of the primary ultrathin nanowires, and a uniform ultrathin graphitic carbon layer, these unique CoO@C dandelions display high specific capacity, good rate capability, and excellent cycling stability. Importantly, this approach can be extended to accurately synthesize other desired composite structures.     

Nutrients Other than Selenium Are Important for Promoting Children’s Health in Kashin-Beck Disease Areas

Overall nutritional status has been proved associated with people’s health. The overall nutritional status of children in Kashin-Beck disease (KBD) areas has been overlooked for decades. Therefore, it is worth investigating in the current generation to gather evidence and make suggestions for improvement. A cross-sectional study with three 24-h dietary recalls was conducted to collect raw data on the daily food intake of children. Recorded food was converted into daily nutrient intakes using CDGSS 3.0 software. WHO AnthroPlus software was used to analyse the BMI-for-age z-score (BAZ) for estimating the overall nutrition status of children. All the comparisons and regression analyses were conducted with SPSS 18.0 software. Multiple nutrient intakes among children from the Se-supplemented KBD-endemic were under the estimated average requirement. The protein-to-carbohydrate ratio (P/C ratio) was significantly higher in children from the non-Se-supplemented KBD-endemic area than the other areas (P < 0.001). The children’s BAZ was negatively associated with age (B = ?0.095, P < 0.001) and the number of KBD relatives (B = ?0.277, P = 0.04), and it was positively associated with better housing conditions, receiving colostrum, and daily intakes of niacin and zinc by multivariate regression analysis (F = 10.337, R = 0.609, P < 0.001).Compared to non-Se-supplemented KBD-endemic area and non-endemic areas, children in Se-supplemented KBD-endemic areas have an insufficient intake of multiple nutrients. School breakfast and lunch programmes are recommended, and strict implementation is the key to ensuring a positive effect.     

伤寒Vi多糖疫苗大规模生产中的工艺改进

对伤寒Ｖｉ多糖疫苗大规模生产进行了三项工艺改进：１．将液体菌种由静止期接种大罐改为对数生长期接种大罐,大罐培养时间可缩短３－４小时。２．２％（Ｖ／Ｖ）甲醛溶液杀菌时间由５℃６小时改为２０－２５℃２小时,能保证杀菌完全。３．用冷酚精制Ｖｉ多糖由常规法改为乳化法,可减少精制次数及冷酚用量,提高多糖收率     

LncRNA SNHG12 promotes tumorigenesis and metastasis in osteosarcoma by upregulating Notch2 by sponging miR-195-5p

Osteosarcoma is the most common primary malignant bone tumor and has a high fatality rate in children and adolescents. Recently, an increasing amount of evidence has demonstrated that lncRNAs have crucial roles in regulating biological characteristics in malignant tumors. Therefore, this research was carried out to uncover the biological function and the potential molecular mechanism of SNHG12 in osteosarcoma. In this study, we found that SNHG12 was significantly upregulated in both osteosarcoma tissues and cell lines and osteosarcoma patients with high levels of SNHG12 tended to have a poor prognosis. We evaluated the biological function of SNHG12 in 143B and U2OS cells and show that the downregulation of SNHG12 suppressed cell proliferation by blocking cell cycle progression at the G0/G1 phase and weakened cell invasion and migration abilities. Dual-luciferase reporter and RIP assays were conducted to confirm that SNHG12 functioned as a ceRNA, modulating the expression of Notch2 by sponging miR-195-5p in osteosarcoma. We further demonstrate that Notch2 played a crucial role in activating the Notch signaling pathway. In conclusion, SNHG12 might serve as a valuable biomarker and prognosis factor in osteosarcoma patients. The SNHG12/miR-195-5p/Notch2-Notch signaling pathway axis might become a novel therapeutic for osteosarcoma.     

Deletion / insertion polymorphisms of the prion protein gene (<Emphasis Type="BoldItalic">PRNP</Emphasis>) in gayal (<Emphasis Type="BoldItalic">Bos frontalis</Emphasis>)

Resistance to fatal disease bovine spongiform encephalopathy (BSE), due to misfolded prion protein in cattle, is associated with a 23-bp indel polymorphism in the putative promoter and a 12-bp indel in intron 1 of the PRNP gene. Gayal (Bos frontalis) is an important semiwild bovid species and of great conservation concern, but till today these indel polymorphisms have not been evaluated in gayals. Therefore, we collected 225 samples of gayals and evaluated the genetic indel polymorphism in the two regions of this PRNP gene. The results revealed high allelic frequencies of insertions at these indel sites: 0.909 and 0.667 for, respectively, the 23 bp and 12 bp indels, both also with significant genotype frequencies (\(\chi ^{2}\): 9.81; 23 bp and \(\chi ^{2}\): 43.56; 12 bp). At the same time, the haplotype data showed indel polymorphisms with extremely low deletion (0.01) in both regions of the PRNP gene. We compared these data with those reported for healthy and BSE-affected cattle (Bos taurus) breeds from two European countries, Germany and Switzerland, and significant difference (\(P\,{<}\,0.001\)) was observed between BSE-affected as well as the healthy cattle. Further, our data were also extensively compared with previous reports on BSE and highly significant (\(P\,{<}\,0.001\)) outcomes were observed. This result suggested negligible genetic susceptibility to BSE in gayals. To the best of our knowledge, this study is the first comprehensive deciphering information about the PRNP indel polymorphisms of 23 bp and 12 bp in gayals, a semiwild species of China.     

Research of population with impulsive perturbations based on dynamics of a neutral delay equation and ecological quality system

This paper studies the global behaviors of a nonlinear autonomous neutral delay differential population model with impulsive perturbation. This model may be suitable for describing the dynamics of population with long larval and short adult phases. It is shown that the system may have global stability of the extinction and positive equilibria, or grow without being bounded under some conditions.     

Consistency maintenance of Do and Undo/Redo operations in real-time collaborative bitmap editing systems

In real-time collaborative graphical editing systems, bitmap-based graphical editing systems are particularly special and practically useful ones, and Do and Undo/Redo operations are intricate problems in this field. However, existing researches on graphical editing systems are quite scanty. In this paper, based on Multi-version strategy, we propose a new approach to solve the Do and Undo/Redo consistency maintenance problems with due consideration of three possible cases: all-causal, all-independent and causal-independent-mixed operations. Compared with previous collaborative algorithms, the algorithms proposed in this paper support Do and Undo/Redo operations without requiring additional space. In addition, two example analyses are also given to prove the algorithms’ effectiveness separately. Furthermore, the time complexity of the two algorithms is both O(n). Finally, a system prototype called bitmap-based Co-Graphical Editor is implemented to verify them realistically.