全文获取类型
收费全文 | 28644篇 |
免费 | 2416篇 |
国内免费 | 1887篇 |
出版年
2024年 | 42篇 |
2023年 | 279篇 |
2022年 | 707篇 |
2021年 | 1258篇 |
2020年 | 852篇 |
2019年 | 1090篇 |
2018年 | 1106篇 |
2017年 | 859篇 |
2016年 | 1231篇 |
2015年 | 1812篇 |
2014年 | 2134篇 |
2013年 | 2217篇 |
2012年 | 2631篇 |
2011年 | 2467篇 |
2010年 | 1458篇 |
2009年 | 1432篇 |
2008年 | 1622篇 |
2007年 | 1439篇 |
2006年 | 1317篇 |
2005年 | 1083篇 |
2004年 | 1065篇 |
2003年 | 893篇 |
2002年 | 683篇 |
2001年 | 494篇 |
2000年 | 415篇 |
1999年 | 395篇 |
1998年 | 270篇 |
1997年 | 220篇 |
1996年 | 228篇 |
1995年 | 186篇 |
1994年 | 169篇 |
1993年 | 92篇 |
1992年 | 147篇 |
1991年 | 113篇 |
1990年 | 118篇 |
1989年 | 84篇 |
1988年 | 67篇 |
1987年 | 72篇 |
1986年 | 43篇 |
1985年 | 60篇 |
1984年 | 41篇 |
1983年 | 18篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1967年 | 2篇 |
1964年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
961.
962.
Xiangqian Zhang Xu Zheng Shanwen Ke Haitao Zhu Fang Liu Zemin Zhang Xinxiang Peng Lin Guo Ruizhen Zeng Pei Hou Ziqiang Liu Suowei Wu Meifang Song Jianping Yang Guiquan Zhang 《Plant molecular biology》2016,92(6):701-715
Most environmental perturbations have a direct or indirect deleterious impact on photosynthesis, and, in consequence, the overall energy status of the cell. Despite our increased understanding of convergent energy and stress signals, the connections between photosynthesis, energy and stress signals through putative common nodes are still unclear. Here we identified an endoplasmic reticulum (ER)-localized adenine nucleotide transporter1 (ER-ANT1), whose deficiency causes seedling lethality in air but viable under high CO2, exhibiting the typical photorespiratory phenotype. Metabolic analysis suggested that depletion of ER-ANT1 resulted in circadian rhythm disorders in sucrose synthesis and induced sucrose signaling pathways, indicating that the ER is involved in the regulation of vital energy metabolism in plants. In addition, the defect of ER-ANT1 triggers ER stress and activates the unfolded protein response in plant cells, suggesting ER stress and photorespiration are closely linked. These findings provide an important evidence for a key role of ER-localized ER-ANT1 in convergent energy and stress signals in rice. Our findings support the idea that ATP is a central signal involved in the plant response to a variety of stresses. 相似文献
963.
964.
965.
966.
967.
Lirong Li Jin Sun Shufang Xia Xu Tian Maureen Jepkorir Cheserek Guowei Le 《Applied microbiology and biotechnology》2016,100(7):3245-3253
968.
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L‐associated PI3K activity
下载免费PDF全文
![点击此处可从《The EMBO journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Da‐Qian Xu Zheng Wang Chen‐Yao Wang De‐Yi Zhang Hui‐Da Wan Zi‐Long Zhao Jin Gu Yong‐Xian Zhang Zhi‐Gang Li Kai‐Yang Man Yi Pan Zhi‐Fei Wang Zun‐Ji Ke Zhi‐Xue Liu Lu‐Jian Liao Yan Chen 《The EMBO journal》2016,35(5):496-514
The Beclin1–VPS34 complex is recognized as a central node in regulating autophagy via interacting with diverse molecules such as ATG14L for autophagy initiation and UVRAG for autophagosome maturation. However, the underlying molecular mechanism that coordinates the timely activation of VPS34 complex is poorly understood. Here, we identify that PAQR3 governs the preferential formation and activation of ATG14L‐linked VPS34 complex for autophagy initiation via two levels of regulation. Firstly, PAQR3 functions as a scaffold protein that facilitates the formation of ATG14L‐ but not UVRAG‐linked VPS34 complex, leading to elevated capacity of PI(3)P generation ahead of starvation signals. Secondly, AMPK phosphorylates PAQR3 at threonine 32 and switches on PI(3)P production to initiate autophagosome formation swiftly after glucose starvation. Deletion of PAQR3 leads to reduction of exercise‐induced autophagy in mice, accompanied by a certain degree of disaggregation of ATG14L‐associated VPS34 complex. Together, this study uncovers that PAQR3 can not only enhance the capacity of pro‐autophagy class III PI3K due to its scaffold function, but also integrate AMPK signal to activation of ATG14L‐linked VPS34 complex upon glucose starvation. 相似文献
969.
970.
Mark C. Vanderwel Hongcheng Zeng John P. Caspersen Georges Kunstler Jeremy W. Lichstein 《Ecology letters》2016,19(4):414-423
Ecologists have limited understanding of how geographic variation in forest biomass arises from differences in growth and mortality at continental to global scales. Using forest inventories from across North America, we partitioned continental‐scale variation in biomass growth and mortality rates of 49 tree species groups into (1) species‐independent spatial effects and (2) inherent differences in demographic performance among species. Spatial factors that were separable from species composition explained 83% and 51% of the respective variation in growth and mortality. Moderate additional variation in mortality (26%) was attributable to differences in species composition. Age‐dependent biomass models showed that variation in forest biomass can be explained primarily by spatial gradients in growth that were unrelated to species composition. Species‐dependent patterns of mortality explained additional variation in biomass, with forests supporting less biomass when dominated by species that are highly susceptible to competition (e.g. Populus spp.) or to biotic disturbances (e.g. Abies balsamea). 相似文献