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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
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Xu Zhang Wei Zhang Santosh L. Saraf Mehdi Nouraie Jin Han Michel Gowhari Johara Hassan Galina Miasnikova Adelina Sergueeva Sergei Nekhai Rick Kittles Roberto F. Machado Joe G. N. Garcia Mark T. Gladwin Martin H. Steinberg Paola Sebastiani Donald A. McClain Victor R. Gordeuk 《Human genetics》2015,134(8):895-904
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The purpose of this review is to provide an overview of the effects of adenovirus and influenza virus infections on obesity in various experimental models. We reviewed studies that were conducted within the past 10 years and were related to virus infection and obesity prevalence. Here, we discuss a different causal relationship between adenovirus and influenza infections with obesity. Adenovirus infection can cause obesity, whereas obesity can be a risk factor for increasing influenza virus infection and increases the risk of morbidity and mortality. The prevalence of obesity due to adenovirus infections may be due to an increase in glucose uptake and reduction in lipolysis caused by an increase in corticosterone secretion. Adenovirus infections may lead to increases in appetite by decreasing norepinephrine and leptin levels and also cause immune dysfunction. The relationship between obesity and influenza virus infection could be summarized by the following features: decreases in memory T-cell functionality and interferon (IFN)-α, IFN-β, and IFN-γ mRNA expression, increases in viral titer and infiltration, and impaired dendritic cell function in obese individuals. Moreover, leptin resistance may play an important role in increasing influenza virus infections in obese individuals. In conclusion, prevention of adenovirus infections could be a good approach for reducing obesity prevalence, and prevention of obesity could reduce influenza virus infections from the point of view of viral infections and obesity. 相似文献
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The 24-h time budget of a takh harem stallion (Equus ferus przewalskii) pre- and post-reintroduction
Lee Boyd 《Applied animal behaviour science》1998,60(4):291-299
Focal animal sampling was used to determine the 24-h time budget of a takh harem stallion (Equus ferus przewalskii) during the 2 weeks prior to, and the two weeks following, reintroduction into the Hustain Nuruu Steppe Reserve, Mongolia. Both before and after release, the stallion spent approximately 47% of his time grazing, 6% standing, and 5% in recumbent rest. The biggest changes to the time budget after release were a 4-fold increase in the amount of time spent moving, and a 50% decrease in the amount of time spent resting in a standing position. During the middle of the day when the temperatures were hottest, the stallion exhibited less grazing and more standing resting behaviour than in the morning or evening hours. Recumbent rest invariably occurred in the hours before dawn. 相似文献
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J Chae M J Kim J H Goo S Collier D Gubb J Charlton P N Adler W J Park 《Development (Cambridge, England)》1999,126(23):5421-5429
The tissue polarity genes control the polarity of hairs, bristles and ommatidia in the adult epidermis of Drosophila. We report here the identification of a new tissue polarity gene named starry night (stan). Mutations in this essential gene alter the polarity of cuticular structures in all regions of the adult body. The detailed polarity phenotype of stan on the wing suggested that it is most likely a component of the frizzled (fz) pathway. Consistent with this hypothesis, stan appears to be downstream of and required for fz function. We molecularly cloned stan and found that it encodes a huge protocadherin containing nine cadherin motifs, four EGF-like motifs, two laminin G motifs, and seven transmembrane domains. This suggests that Stan functions in signal reception, perhaps together with Fz. 相似文献
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