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91.
将诱变的αCD3杂交瘤(TK~-)与PD4杂交瘤(HGPRT~-)融合,获得分泌双功能抗体(BsAb)的四体杂交瘤C3.BsAbC3可分别与CD3分子及胃癌相关抗原P40反应.体外杀伤试验证实,当效靶比为40:1,BsAbC3浓度为1mg/L时,其杀伤效应可达77.6%.该杀伤效应具有明显的特异性,仅P40阳性表达的靶细胞可被溶解,体内杀伤试验证实,裸鼠接种胃癌细胞后5d,以BsAbC3活化的外周血淋巴细胞(PBLs)经局部皮下注射处理,可使移植胃癌完全消退(5/5).这一明显的治疗作用可能与局部注射途径有关,可供临床应用参考. 相似文献
92.
根据14丘稻田稻茎毛眼水蝇幼虫调查资料.对其幼虫分布型进行了分析。结果表明;用I、CAm/m、Iσ四种聚集指标法测定,64.3%的田块呈随机分布.28.4%为均匀分布.7.3%为聚集分布。用Iwao平均拥挤度和Taylor幂法则测定.其田间分布型符合随机分布。用频次拟合法测验,50%的田块同时符合渡松、奈曼和负二项分布三种分布型;35.7%的田块同时符合2种分布型。根据该虫田间分布型的特点.制定了相应的序贯抽样技术。 相似文献
93.
长果秤锤树保护现状的初步研究 总被引:2,自引:0,他引:2
本文从自然环境、种群分布、数量、种群结构、人为破坏、保护及管理等方面分析了湖南石门长果秤锤树的就地保护现状,并从种子繁殖、扦插繁殖、栽培、试管保存及开发利用潜力等方面总结了武汉植物所近年来对长果秤锤树进行迁地保护研究的初步成果,并提出了相应的保护措施。 相似文献
94.
Properties of EPSP, evoked in efferent neurons of the parietal associative cortex by stimulation of the cerebellar nuclei, were studied in acute experiments on anesthetized and immobilized cats; intracellular recording was used. The neurons were identified by their antidromic activation after stimulation of the motor cortex, pontinen.n. proprii, or red nucleus. The effects of stimulation of the cerebellar nuclei were of oligo- and polysynaptic nature. The latencies of cerebellofugal EPSP correlated with the latencies of antidromic activation, and correlations were significant both in the cases when the effects of stimulation of separate efferent projections (cortico-cortical, cortico-pontine, or cortico-rubral) and the effects of stimulation of separate cerebellar nuclei were analyzed. The functional role of the efferent systems of the parietal associative cortex and significance of functional parameters of the neurons constituting these systems are discussed.Neirofiziologiya/Neurophysiology, Vol. 27, No. 3, pp. 190–198, May–June, 1995. 相似文献
95.
Two ruthenium(II) complexes with polypyridyl, Ru(bipy)2(phen)](ClO4)2·H2O (1) and [Ru(bipy)2(Me-phen)](ClO4)2 (2), (phen = 1,10-phenanthroline, bipy = 2,2′-bipyridine, Me-phen = 5-methyl-1,10-phenanthroline), were synthesized and characterized by IR, MS and NMR spectra. Their structures were determined by single crystal X-ray diffraction techniques. The strong steric interaction between the polypyridyl ligands was relieved neither by the elongation of the Ru---N bonds nor increase of the N---Ru---N bite angles. The coordination sphere was distorted to relieve the ligand interaction by forming specific angles (δ) between the polypyridyl ligand planes and coordination planes (N---Ru---N), and forming larger twisted angles between the two pyridine rings for each bipy. The bond distances of Ru---N(bipy) and Ru---N(phen) were virtually identical with experimental error, as expected of π back-bonding interactions which statistically involve each of the ligands present in the coordination sphere. 相似文献
96.
On the production,elemental composition (C,N, P) and distribution of photosynthetic organic matter in the Southern Black Sea 总被引:2,自引:1,他引:1
Yılmaz Ayşen Tuğrul Süleyman Polat Çolpan Ediger Dilek Çoban Yeşim Morkoç Enis 《Hydrobiologia》1997,363(1-3):141-155
Chemical oceanographic understanding of the southernBlack Sea has been improved by recent measurements ofthe optical transparency,
phytoplankton biomass (interms of chlorophyll-a and particulate organic matter)and primary productivity. During the spring-autmunperiod
of 1995–1996, light generally penetrated onlyinto the upper 15–40 m, with an attenuation coefficientvarying between 0.125
and 0.350 m2122;1. The averagechlorophyll-a (Chl-a) concentrations for the euphoticzone ranged from 0.1 to 1.5 μg l2122;1. Coherentsub-surface Chl-a maxima were formed near the base ofthe euphotic zone only in summer. Production rate variedbetween
247 and 1925 in the spring and between 405 and687 mgC m2122;2 d2122;1 in the summer-autumn period.The average POM concentrations in the euphotic zonevaried regionally and seasonally between 3.8
and28.6 μm for POC, 0.5 and 3.1 μm for PON and0.02 and 0.1 μm for PP. Atomic ratios of C/N, C/Pand N/P, derived from the regressions
of POM data,ranged between 7.5 and 9.6, 109 and 165, and 11.2 and16.6, respectively. In the suboxic/anoxic interface,the elemental
ratios change substantially due to anaccumulation of PP cohering to Fe and Mn oxides. Thechemocline boundaries and the distinct
chemicalfeatures of the oxic/anoxic transition layer (the so-called suboxic zone) are all located at specificdensity surfaces;
however, they exhibit remarkablespatial and temporal variations both in their positionand in their magnitude, which permit
the definition of long-term changes in the biochemical properties of theBlack Sea upper layer.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
97.
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99.
将大鼠置于模拟海拔8km高度的低压舱内缺氧1周及缺氧后空气中常氧恢复1周和2周,观察了左右心室功能、心肌肥厚、心肌收缩蛋白含量及其Ca ̄(2+),Mg ̄(2+)-ATP酶活性的动态变化。结果表明,8km缺氧1周后肺动脉压及右心室收缩压明显升高,左右心室±dp/dtmax及收缩指数明显降低。左右心室肌明显肥厚,心肌收缩蛋白Ca ̄(2+),Mg ̄(2+)-ATP酶活性明显减低。缺氧后常氧恢复1和2周后,左右心室功能逐渐恢复达到或接近正常水平,心肌肥厚逐渐减轻或恢复正常,心肌收缩蛋白Ca ̄(2+),Mg ̄(2+)-ATP酶活性也逐渐升高。因此说明:心肌收缩蛋白Ca ̄(2+),Mg ̄(2+)-ATP酶活性的改变是心功能变化的重要生化基础之一,它的减低是缺氧心肌对环境的代偿适应。 相似文献
100.
本文研究TSH和forskolin对原代培养的猪甲状腺细胞[Ca~(2+)]_i和钙调蛋白的影响。结果表明,TSH可引起甲状腺细胞[Ca~(2+)]_1急性升高。此反应是剂量依赖关系,而与细胞外钙的存在与否无关。其反应性在细胞单层高于细胞是液,近汇合细胞单层高于汇合细胞单层。TSH作用3天,可使甲状腺细胞的钙调蛋白含量增高,此作用与TSH对甲状腺细胞数的影响无关。Forskolin对甲状腺细胞的[Ca~(2+)]_i和钙调蛋白均无明显的影响。 相似文献