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Rui Zhou Huiying Sun Siting Zheng Jingwen Zhang Dongqiang Zeng Jianhua Wu Zhenhua Huang Xiaoxiang Rong Jianping Bin Yulin Liao Min Shi Wangjun Liao 《Journal of cellular and molecular medicine》2020,24(5):3229-3241
The heterogeneity in prognoses and chemotherapeutic responses of colon cancer patients with similar clinical features emphasized the necessity for new biomarkers that help to improve the survival prediction and tailor therapies more rationally and precisely. In the present study, we established a s troma-related l ncRNA s ignature (SLS) based on 52 lncRNAs to comprehensively predict clinical outcome. The SLS model could not only distinguish patients with different recurrence and mortality risks through univariate analysis, but also served as an independent factor for relapse-free and overall survival. Compared with the conventionally used TNM stage system, the SLS model clearly possessed higher predictive accuracy. Moreover, the SLS model also effectively screened chemotherapy-responsive patients, as only patients in the low-SLS group could benefit from adjuvant chemotherapy. The following cell infiltration and competing endogenous RNA (ceRNA) network functional analyses further confirmed the association between the SLS model and stromal activation-related biological processes. Additionally, this study also identified three phenotypically distinct colon cancer subtypes that varied in clinical outcome and chemotherapy benefits. In conclusion, our SLS model may be a significant determinant of survival and chemotherapeutic decision-making in colon cancer and may have a strong clinical transformation value. 相似文献
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Ligang Wang Xinxuan Duan Xijun Liu Jing Gu Rui Si Yi Qiu Yaming Qiu Dier Shi Fanhong Chen Xiaoming Sun Jianhua Lin Junliang Sun 《Liver Transplantation》2020,10(4)
Water splitting requires development of cost‐effective multifunctional materials that can catalyze both the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) efficiently. Currently, the OER relies on the noble‐metal catalysts; since with other catalysts, its operation environment is greatly limited in alkaline conditions. Herein, an advanced water oxidation catalyst based on metallic Co9S8 decorated with single‐atomic Mo (0.99 wt%) is synthesized (Mo‐Co9S8@C). It exhibits pronounced water oxidization activity in acid, alkali, and neutral media by showing positive onset potentials of 200, 90, and 290 mV, respectively, which manifests the best Co9S8‐based single‐atom Mo catalyst till now. Moreover, it also demonstrates excellent HER performance over a wide pH range. Consequently, the catalyst even outperforms noble metal Pt/IrO2‐based catalysts for overall water splitting (only requiring 1.68 V in acid, and 1.56 V in alkaline). Impressively, it works under a current density of 10 mA cm?2 with no obvious decay during a 24 h (0.5 m H2SO4) and 72 h (1.0 m KOH) durability experiment. Density functional theory (DFT) simulations reveal that the synergistic effects of atomically dispersed Mo with Co‐containing substrates can efficiently alter the binding energies of adsorbed intermediate species and decrease the overpotentials of the water splitting. 相似文献
35.
Changzhi Sun Aming Lin Wenwen Li Jun Jin Yiyang Sun Jianhua Yang Zhaoyin Wen 《Liver Transplantation》2020,10(3)
The introduction of 3D wettable current collectors is one of the practical strategies toward realizing high reversibility of lithium (Li) metal anodes, yet its effect is usually insufficient owing to single electron‐conductive skeleton. Here, homogeneous Li deposition behavior and enhanced Coulombic efficiency is reported for electrochemically lithiated Cu3P nanowires, owing to the formation of a mixed ion/electron‐conducting skeleton (MIECS). In particular, by evaluating the Gibbs free energy change, the possible chemical reaction between Cu3P and molten Li is used to construct a MIECS containing Li3P and Cu–Li alloy phase. The successful conversion of Cu3P nanowires to Li3P and Cu–Li alloy nanocomposite not only greatly reduces the surface energy between molten Li and Cu3P, but also induces uniform Li stripping/plating behavior via balanced ion/electron transport. Thus, the as‐obtained Li@MIECS composite anode displays superior cycling stability in both symmetric cells and full cells. This work provides a promising option for the preparation of high‐performance composite Li anodes containing MIECS by thermally pre‐storing Li. 相似文献
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Changjian Zuo Zongxiang Hu Rui Qi Jiajie Liu Zhibo Li Junliang Lu Cheng Dong Kai Yang Weiyuan Huang Cong Chen Zhibo Song Sicheng Song Yaoming Yu Jiaxin Zheng Feng Pan 《Liver Transplantation》2020,10(34)
The relatively low capacity and capacity fade of spinel LiMn2O4 (LMO) limit its application as a cathode material for lithium‐ion batteries. Extending the potential window of LMO below 3 V to access double capacity would be fantastic but hard to be realized, as it will lead to fast capacity loss due to the serious Jahn–Teller distortion. Here using experiments combined with extensive ab initio calculations, it is proved that there is a cooperative effect among individual Jahn–Teller distortions of Mn3+O6 octahedrons in LMO, named as cooperative Jahn–Teller distortion (CJTD) in the text, which is the difficulty to access the capacity beyond one lithium intercalation. It is further proposed that the cationic disordering (excess Li at Mn sites and Li/Mn exchange) can intrinsically suppress the CJTD of Mn3+O6 octahedrons. The cationic disordering can break the symmetry of Mn3+ arrangements to disrupt the correlation of distortions arising from individual JT centers and prevent the Mn3+? O bonds distorting along one direction. Interestingly, with the suppressed CJTD, the original octahedral vacancies in spinel LMO are activated and can serve as extra Li‐ion storage sites to access the double capacity with good reversible cycling stability in microsized LMO. 相似文献
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Self-assembled DNA nanostructures have shown remarkable potential in the engineering of biosensing interfaces, which can improve the performance of various biosensors. In particular, by exploiting the structural rigidity and programmability of the framework nucleic acids with high precision, molecular recognition on the electrochemical biosensing interface has been significantly enhanced, leading to the development of highly sensitive and specific biosensors for nucleic acids, small molecules,proteins, and cells. In this review, we summarize recent advances in DNA framework-engineered biosensing interfaces and the application of corresponding electrochemical biosensors. 相似文献
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Jinwang Ye Yaling Yin Huanhuan Liu Lin Fang Xiaoqing Tao Linyu Wei Yue Zuo Ying Yin Dan Ke Jian‐Zhi Wang 《Aging cell》2020,19(1)
Intraneuronal accumulation of wild‐type tau plays a key role in Alzheimer's disease, while the mechanisms underlying tauopathy and memory impairment remain unclear. Here, we report that overexpressing full‐length wild‐type human tau (hTau) in mouse hippocampus induces learning and memory deficits with remarkably reduced levels of multiple synapse‐ and memory‐associated proteins. Overexpressing hTau inhibits the activity of protein kinase A (PKA) and decreases the phosphorylation level of cAMP‐response element binding protein (CREB), GluA1, and TrkB with reduced BDNF mRNA and protein levels both in vitro and in vivo. Simultaneously, overexpressing hTau increased PKAR2α (an inhibitory subunit of PKA) in nuclear fraction and inactivated proteasome activity. With an increased association of PKAR2α with PA28γ (a nuclear proteasome activator), the formation of PA28γ‐20S proteasome complex remarkably decreased in the nuclear fraction, followed by a reduced interaction of PKAR2α with 20S proteasome. Both downregulating PKAR2α by shRNA and upregulating proteasome by expressing PA28γ rescued hTau‐induced PKA inhibition and CREB dephosphorylation, and upregulating PKA improved hTau‐induced cognitive deficits in mice. Together, these data reveal that intracellular tau accumulation induces synapse and memory impairments by inhibiting PKA/CREB/BDNF/TrkB and PKA/GluA1 signaling, and deficit of PA28γ‐20S proteasome complex formation contributes to PKAR2α elevation and PKA inhibition. 相似文献