Weighted double deep Q-network based reinforcement learning for bi-objective multi-workflow scheduling in the cloud

Cluster Computing - As a promising distributed paradigm, cloud computing provides a cost-effective deploying environment for hosting scientific applications due to its provisioning elastic,...     

Effects of PAMK on lncRNA,miRNA, and mRNA expression profiles of thymic epithelial cells

Functional & Integrative Genomics - Polysaccharides from Atractylodes macrocephala Koidz (PAMK) can promote the proliferation of thymocytes and improve the body’s immunity. However, the...     

ANGPTL4 regulates the osteogenic differentiation of periodontal ligament stem cells

Functional & Integrative Genomics - The molecular mechanism of mechanical force regulating the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) has not been clearly...     

Analytical comparison of absolute quantification strategies to investigate the insulin signaling pathway in fat cells

So far, mass spectrometry-based targeted proteomics is the most sensitive approach to answer and address specific biological questions in an accurate and quantitative fashion. However, the data analysis design used for such quantification varies in the field leading to discrepancies in the reported values. In this study, different quantification strategies based on calibration curves were evaluated and compared. The best accuracy and coefficient of variation was achieved by ratio to ratio calibration curves. We applied the ratio to ratio quantification approach to analyze very low abundant insulin signaling proteins such as PIK3RA (0.10–0.93 fmol/μg), AKT1 (0.1–0.39 fmol/μg), and the insulin receptor (0.22–2.62 fmol/μg) in a fat cell model and demonstrated the adaptation of this pathway at different states of insulin sensitivity.     

CircRNAs Biogenesis,Functions, and Its Research Progress in Aquaculture

Russian Journal of Bioorganic Chemistry - CircRNAs is a novel type of endogenous RNA molecule that is produced from pre-mRNA without 5′cap and a tail of 3′polyA. It characterized by the...     

Design,Synthesis, and Biological Evaluation of a Novel Series of Pirfenidone Derivatives

Russian Journal of Bioorganic Chemistry - In this study, a series of novel pirfenidone derivatives were designed and synthesized, and their activities against pulmonary fibrosis were evaluated. The...     

Morphological and transcriptomic analysis of attenuated and virulent strains of Phytophthora infestans

International Microbiology - Phytophthora infestans is a hemibiotroph Oomycete that primarily infects tomato. In this study, the growth status and pathogenicity of attenuated and virulent strains...     

Transcriptome sequencing and global analysis of blue light-responsive genes provide clues for high carotenoid yields in Blakeslea trispora

International Microbiology - Blakeslea trispora has great potential uses in industrial production because of the excellent capability of producing a large quantity of carotenoids. However, the...