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排序方式: 共有7716条查询结果,搜索用时 500 毫秒
71.
Both obesity and gestational diabetes mellitus (GDM) lead to poor maternal and fetal outcomes, including pregnancy complications, fetal growth issues, stillbirth, and developmental programming of adult-onset disease in the offspring. Increased placental oxidative/nitrative stress and reduced placental (trophoblast) mitochondrial respiration occur in association with the altered maternal metabolic milieu of obesity and GDM. The effect is particularly evident when the fetus is male, suggesting a sexually dimorphic influence on the placenta. In addition, obesity and GDM are associated with inflexibility in trophoblast, limiting the ability to switch between usage of glucose, fatty acids, and glutamine as substrates for oxidative phosphorylation, again in a sexually dimorphic manner. Here we review mechanisms underlying placental mitochondrial dysfunction: its relationship to maternal and fetal outcomes and the influence of fetal sex. Prevention of placental oxidative stress and mitochondrial dysfunction may improve pregnancy outcomes. We outline pathways to ameliorate deficient mitochondrial respiration, particularly the benefits and pitfalls of mitochondria-targeted antioxidants. 相似文献
72.
Jonathan C. Guito Joseph B. Prescott Catherine E. Arnold Brian R. Amman Amy J. Schuh Jessica R. Spengler Tara K. Sealy Jessica R. Harmon JoAnn D. Coleman-McCray Kirsten A. Kulcsar Elyse R. Nagle Raina Kumar Gustavo F. Palacios Mariano Sanchez-Lockhart Jonathan S. Towner 《Current biology : CB》2021,31(2):257-270.e5
73.
74.
Hui Li Shuyi Wang Fang-Hua Lee Ryan S. Roark Alex I. Murphy Jessica Smith Chengyan Zhao Juliette Rando Neha Chohan Yu Ding Eunlim Kim Emily Lindemuth Katharine J. Bar Ivona Pandrea Cristian Apetrei Brandon F. Keele Jeffrey D. Lifson Mark G. Lewis Thomas N. Denny Barton F. Haynes Beatrice H. Hahn George M. Shaw 《Journal of virology》2021,95(11)
75.
Leduc Antoine O. H. C. Costa Jessica S. Oliveira do Nascimento Silva Renata R. Winandy Gabrielle S. M. de Araújo Carlos B. 《Journal of Ethology》2021,39(2):225-234
Journal of Ethology - Noise pollution may impair the cognitive performances of several animal species, producing suboptimal behavioral responses. Involuntary shifts in attention from noise... 相似文献
76.
Nicholas Murgolo Alex G. Therien Bonnie Howell Daniel Klein Kenneth Koeplinger Linda A. Lieberman Gregory C. Adam Jessica Flynn Philip McKenna Gokul Swaminathan Daria J. Hazuda David B. Olsen 《PLoS pathogens》2021,17(2)
Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally. While the effects of SARS-CoV-2 infection are not completely understood, there appears to be a wide spectrum of disease ranging from mild symptoms to severe respiratory distress, hospitalization, and mortality. There are no Food and Drug Administration (FDA)-approved treatments for COVID-19 aside from remdesivir; early efforts to identify efficacious therapeutics for COVID-19 have mainly focused on drug repurposing screens to identify compounds with antiviral activity against SARS-CoV-2 in cellular infection systems. These screens have yielded intriguing hits, but the use of nonhuman immortalized cell lines derived from non-pulmonary or gastrointestinal origins poses any number of questions in predicting the physiological and pathological relevance of these potential interventions. While our knowledge of this novel virus continues to evolve, our current understanding of the key molecular and cellular interactions involved in SARS-CoV-2 infection is discussed in order to provide a framework for developing the most appropriate in vitro toolbox to support current and future drug discovery efforts. 相似文献
77.
Joy H. Meserve Jessica C. Nelson Kurt C. Marsden Jerry Hsu Fabio A. Echeverry Roshan A. Jain Marc A. Wolman Alberto E. Pereda Michael Granato 《PLoS genetics》2021,17(6)
The acoustic startle response is an evolutionarily conserved avoidance behavior. Disruptions in startle behavior, particularly startle magnitude, are a hallmark of several human neurological disorders. While the neural circuitry underlying startle behavior has been studied extensively, the repertoire of genes and genetic pathways that regulate this locomotor behavior has not been explored using an unbiased genetic approach. To identify such genes, we took advantage of the stereotypic startle behavior in zebrafish larvae and performed a forward genetic screen coupled with whole genome analysis. We uncovered mutations in eight genes critical for startle behavior, including two genes encoding proteins associated with human neurological disorders, Dolichol kinase (Dolk), a broadly expressed regulator of the glycoprotein biosynthesis pathway, and the potassium Shaker-like channel subunit Kv1.1. We demonstrate that Kv1.1 and Dolk play critical roles in the spinal cord to regulate movement magnitude during the startle response and spontaneous swim movements. Moreover, we show that Kv1.1 protein is mislocalized in dolk mutants, suggesting they act in a common genetic pathway. Combined, our results identify a diverse set of eight genes, all associated with human disorders, that regulate zebrafish startle behavior and reveal a previously unappreciated role for Dolk and Kv1.1 in regulating movement magnitude via a common genetic pathway. 相似文献
78.
Tra-My N. Duong Thanh-Van Le Khanh-Linh H. Tran Phuong-Tuyen Nguyen Bich-Phuong T. Nguyen Thu-Anh Nguyen Huong-Lan P. Nguyen Bich-Ngoc T. Nguyen Matthew C. Fisher Johanna Rhodes Guy Marks Greg J. Fox Sharon C.-A. Chen Michael G. Walsh Vanessa R. Barrs Jessica Talbot Catriona L. Halliday Tania C. Sorrell Jeremy N. Day Justin Beardsley 《Environmental microbiology》2021,23(12):7632-7642
Azole-resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land-use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. Of 119 ASF isolates, 55% were resistant (or non-wild type) to itraconazole, 65% to posaconazole and 50% to voriconazole. Azole resistance was more frequent in A. fumigatus sensu stricto isolates (95%) than other ASF species (32%). Resistant isolates and agricultural azole residues were overrepresented in samples from cultivated land. cyp51A gene sequence analysis showed 38/56 resistant A. fumigatus sensu stricto isolates carried known resistance mutations, with TR34/L98H most frequent (34/38). 相似文献
79.
Laritza Rojas Aymara Cabrera-Muñoz Dayrom Gil Pradas Jessica B. González Maday Alonso-del-Rivero Yamile González-González 《Biochemistry and Biophysics Reports》2021
CmPI-II is a Kazal-type tight-binding inhibitor isolated from the Caribbean snail Cenchritis muricatus. This inhibitor has an unusual specificity in the Kazal family, as it can inhibit subtilisin A (SUBTA), elastases and trypsin. An alanine in CmPI-II P1 site could avoid trypsin inhibition while improving/maintaining SUBTA and elastases inhibition. Thus, an alanine mutant of this position (rCmPI-II R12A) was obtained by site-directed mutagenesis. The gene cmpiR12A was expressed in P. pastoris KM71H yeast. The recombinant protein (rCmPI-II R12A) was purified by the combination of two ionic exchange chromatography (1:cationic, 2 anionic) followed by and size exclusion chromatography. The N-terminal sequence obtained as well as the experimental molecular weight allowed verifying the identity of the recombinant protein, while the correct folding was confirmed by CD experiments. rCmPI-II R12A shows a slightly increase in potency against SUBTA and elastases. The alanine substitution at P1 site on CmPI-II abolishes the trypsin inhibition, confirming the relevance of an arginine residue at P1 site in CmPI-II for trypsin inhibition and leading to a molecule with more potentialities in biomedicine. 相似文献
80.
Andrei Kochegarov Ashley Moses William Lian Jessica Meyer Michael C Hanna Larry F Lemanski 《Journal of biomedical science》2013,20(1):20