The effect of DL-β-methylaspartic acid on the growth ofEscherichia coli

ВЫла кислота была под готовлена и двух его и зомеры отделить друг от друга. Больше erythro-раст воримой форме стимул ировали рост (itEscherichia титр) в синтетических средн ие на концентрацию 1–5 gmmoles мл. Менее растворимы е фракции, содержащие threo-форма препятствует росту из (itEscherichia коли) на дан ной концентрации. Инг ибирование роста сви детельствует путем п ролонгации лаг фазы; Темпы роста в логари фмической фазы и Макс имальное количество ячеек не были пострад авшим от аналога. Торм озящий последствия, в ызванные threo-форма methylaspartic ки слоты могут быть пода влены Помимо этого из аспарагиновой кисло ты.     

Biliary excretion of [C]succinylsulphathiazole in the rat and rabbit

1. After intravenous injection about 30% of the dose (20mg./kg.) of succinylsulphathiazole is excreted unchanged in the bile in 3hr. by the rat, whereas only about 1% is excreted by the rabbit. When the renal pedicles are ligated the biliary excretion of succinylsulphathiazole in the rat increases to about 80% of the dose, but in the rabbit under these conditions the biliary excretion is only 2% of the dose. 2. In the rat, the sulphonamide readily enters the liver and biliary excretion occurs against a concentration gradient from liver to bile; further, the excretory process can be saturated, and can be depressed by the simultaneous administration of phenolphthalein glucuronide or bile salts. 3. In the rabbit, these conditions have not been found; succinylsulphathiazole does not readily enter the liver from the plasma, there is no transfer of the drug from the liver cells to the bile against a concentration gradient, and no saturation or depression of the biliary excretion of succinylsulphathiazole is found. 4. It is suggested that two factors responsible, at least partly, for the low biliary excretion of succinylsulphathiazole in the rabbit are the poor entry of the sulphonamide into the liver in this species and a deficiency of the concentrative mechanism for its excretion in the bile.     

Inclusions cytoplasmiques lamellaires dans les tubes collecteurs du rein au cours de la néphrose osmotique

Summary Osmotic nephrosis was induced in mice by intraperitoneal injections of a solution of sucrose or glucose. In most of the animals, the pale cells of the initial segment of the collecting tubules contain extremely peculiar dense granules. These inclusions contain lamellar systems of which the appearance closely resembles that of lecithine-cholesterol dispersions, as observed with an electron microscope after negative staining. These inclusions, which are probably related with the resorbtive function of the pale cells, are considered as residual bodies, and classified as belonging to the lysosome family.

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Zusammenfassung Osmotische Nephrosen wurden durch intraperitoneale Injektionen von Saccharose bzw. Glukose erzeugt. Bei den meisten der untersuchten weißen Mäuse findet man in den hellen Zellen der Pars proximalis der Sammelrose dunkle Einschlüsse von besonderem Aussehen. Diese Einschlüsse enthalten eine lamellenartige Innenstruktur, welche an Dispersionen von Lecithin oder Lecithin-Cholesterin in elektronenoptischen Aufnahmen nach negative staining erinnern. Diese Einschlüsse der Sammelrohrzellen stehen wahrscheinlich zu der Funktion der Reabsorption in Beziehung; sie gehören nach unserer Auffassung mit den Residualkörpern (residual body) zur Gruppe der Lysosomen.

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Ce travail a partiellement bènèficiè de l'aide du Fonds National Suisse de la Recherche Scientifique et de la contribution du «Consiglio Nazionale délie Ricerche», Italie.     

Evaluation of the Urea Washout Pyelogram and Urography in the Assessment of Renovascular Hypertension

The urea washout (UWT) modification of the intravenous pyelogram was used to study 146 hypertensive patients in order to detect the presence of significant renovascular abnormalities. A positive result was obtained in 55 patients and direct confirmation of main renal artery stenoses by selective renal arteriography was obtained in 26. Bilateral abnormalities were confirmed in seven of the 26 patients. No false-negative results were encountered. The usefulness of this test as a comprehensive screening test is outlined. It demonstrated a high degree of accuracy in the diagnosis of significant unilateral or bilateral main renal artery stenosis in addition to the detection of diffuse intrarenal arteriolar disease. It was of value in the postoperative assessment of operative repair of main renal artery defects. The urea washout test embodies both an anatomical and a physiological approach in the roentgen diagnosis of curable renovascular hypertension. The altered physiology resulting from significant main renal artery stenosis makes possible the use of the urea washout intravenous pyelogram. The value of other forms of intravenous pyelography is described.