全文获取类型
收费全文 | 1311篇 |
免费 | 68篇 |
出版年
2022年 | 6篇 |
2021年 | 12篇 |
2019年 | 11篇 |
2018年 | 9篇 |
2017年 | 10篇 |
2016年 | 23篇 |
2015年 | 29篇 |
2014年 | 38篇 |
2013年 | 88篇 |
2012年 | 93篇 |
2011年 | 77篇 |
2010年 | 47篇 |
2009年 | 47篇 |
2008年 | 66篇 |
2007年 | 63篇 |
2006年 | 67篇 |
2005年 | 68篇 |
2004年 | 54篇 |
2003年 | 57篇 |
2002年 | 67篇 |
2001年 | 14篇 |
2000年 | 12篇 |
1999年 | 16篇 |
1998年 | 15篇 |
1997年 | 16篇 |
1996年 | 19篇 |
1995年 | 17篇 |
1994年 | 11篇 |
1993年 | 9篇 |
1992年 | 21篇 |
1991年 | 12篇 |
1990年 | 17篇 |
1989年 | 8篇 |
1988年 | 12篇 |
1986年 | 10篇 |
1985年 | 13篇 |
1984年 | 12篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1979年 | 6篇 |
1977年 | 8篇 |
1976年 | 8篇 |
1975年 | 5篇 |
1974年 | 7篇 |
1973年 | 5篇 |
1858年 | 7篇 |
1857年 | 48篇 |
1855年 | 8篇 |
1854年 | 24篇 |
1853年 | 8篇 |
排序方式: 共有1379条查询结果,搜索用时 15 毫秒
981.
Histone H10 a differentiation-specific member of the histone H1 family, accumulates in cells during the terminal phase of cell differentiation, in tissues composed of arrested cells or cells exhibiting little proliferation. Moreover, the induction of cell proliferation in vivo, i.e., after partial hepatectomy, is accompanied by a decrease in H10 content. These observations suggest that H10 may be involved in the arrest of cell proliferation in vivo. In order to investigate this possibility, we took advantage of the fact that after partial hepatectomy the initiation of cell division is not synchronous. The strategy was to know, at the level of a single cell, whether H10 decreases prior to the initiation of the S phase or whether a cell can initiate DNA replication having a significant amount of H10 in the nucleus. We defined new protocols to analyze H10 content and cell proliferation at the level of a single cell, both in situ and by flow cytometry. The simultaneous determination of the relative amount of H10 and the position of cells in the cell cycle showed that no significant difference in H10 content was detected in cells actively replicating their DNA compared to nondividing cells. These observations have been confirmed by the successive immunodetections of H10 and BrdU in situ on the same cells. Therefore, we show here that in vivo, cells can initiate DNA replication with significant amounts of H10 and that the decrease of H10 is not a prerequisite of cell division. We propose that the accumulation of H10 is not related to the arrest of cell proliferation, but is controlled in such a manner that the protein accumulates in slowly dividing cells and decreases in rapidly growing cells. 相似文献
982.
Jean-Jacques Lafitte Geneviéve Lamblin Michel Lhermitte Pascale Humbert Pierre Degand Phillippe Roussel 《Carbohydrate research》1977,56(2):385-389
Bronchial mucins, prepared from washings performed in macroscopically healthy areas of bronchial mucosa from 6 adult individuals, are glycoproteins of acidic nature that contained both sialic acid residues and sulfate groups. The number of sialic acid residues was greater than the number of sulfate groups. 相似文献
983.
Influence of Region-Specific Alterations of Neuropeptidase Content on the Catabolic Fates of Neuropeptides in Alzheimer's Disease 总被引:1,自引:0,他引:1
Carole Ichai Nathalie Chevallier Pia Delaere †Pascal Dournaud †Jacques Epelbaum Jean-Jacques Hauw Jean-Pierre Vincent Frédéric Checler 《Journal of neurochemistry》1994,62(2):645-655
Abstract: We established the cartography of 11 exo- and endopeptidases in the frontal and parietal cortices and in the cerebellum of brains of patients diagnosed with a senile dementia of the Alzheimer's type (SDAT). Comparison with those of four subjects who had died without known neurologic or psychiatric illness indicated that there existed a region-specific alteration of the peptidase contents in the disease. In the frontal area of SDAT brains, postproline dipeptidyl aminopeptidase and aminopeptidase M activities were significantly reduced. In the parietal cortex of SDAT brain, activities of three additional endopeptidases—angiotensin-converting enzyme, proline endopeptidase, and endopeptidase 24.15—were also drastically reduced. In contrast, the cerebellum displayed a set of proteolytic activities that remained unaffected in SDAT brain. The putative influence of the disease on the catabolic fates of neurotensin, neuropeptide Y, and somatostatin(1–14) was investigated. Neurotensin was catabolized at identical rates in the frontal and parietal cortices in nondemented and SDAT brains. In contrast, neuropeptide Y metabolism was slowed down in SDAT brains in the frontal but not in the parietal cortex. Finally, the degradation velocities of somatostatin(1–14) were lowered in both cortical areas of SDAT brains. It is interesting that, by means of specific peptidase inhibitors, we demonstrated that endopeptidase 24.15 participated in somatostatin(1–14) inactivation in the parietal but not in the frontal cortex. It is suggested that the lowering of the rate of somatostatin(1–14) inactivation in the parietal cortex of SDAT brains likely results from the depletion of endopeptidase 24.15 in this brain region. 相似文献
984.
H. Schott W. Heβ B. Leitner R. A. Schwendener 《Nucleosides, nucleotides & nucleic acids》2013,32(5-6):721-723
Abstract The prodrug N+-oleoyl ara C was incorporated into the membranes of functionalized unilamellar liposomes which were coupled to monoclonal antibodies. Cell-targeting of the prodrug-liposome-antibody complexes was investigated in vitro. 相似文献
985.
986.
Deravet Nicolas Orban de Xivry Jean-Jacques Ivanoiu Adrian Bier Jean-Christophe Segers Kurt Yüksel Demet Lefèvre Philippe 《Journal of computational neuroscience》2021,49(3):357-369
Journal of Computational Neuroscience - Prediction and time estimation are all but required for motor function in everyday life. In the context of eye movements, for instance, they allow predictive... 相似文献
987.
988.
Eric Fouache Jean-Jacques Dufaure Michelle Denèfle Anne-Marie Lézine Pétrika Léra Frano Prendi Gilles Touchais 《Vegetation History and Archaeobotany》2001,10(2):79-86
The archaeological site of Sovjan is located at the edge of lake Maliq. It was occupied from the early Bronze Age to the
early Iron Age. Pollen data from a short sequence of peat deposits dated between 4255±50 and 2420±45 uncal B.P. and charcoal,
seeds and wood from archaeological deposits have provided new information on human activities in the region. They are discussed
in the general frame of agricultural developments in the Balkans. Regional environment (regarding vegetation and hydrology)
and climate are also discussed.
Received June 15, 2000 / Accepted March 8, 2001 相似文献
989.