全文获取类型
收费全文 | 15874篇 |
免费 | 1621篇 |
国内免费 | 3篇 |
出版年
2022年 | 89篇 |
2021年 | 161篇 |
2020年 | 155篇 |
2019年 | 244篇 |
2018年 | 274篇 |
2017年 | 287篇 |
2016年 | 380篇 |
2015年 | 621篇 |
2014年 | 646篇 |
2013年 | 884篇 |
2012年 | 919篇 |
2011年 | 842篇 |
2010年 | 668篇 |
2009年 | 607篇 |
2008年 | 777篇 |
2007年 | 805篇 |
2006年 | 786篇 |
2005年 | 842篇 |
2004年 | 788篇 |
2003年 | 888篇 |
2002年 | 899篇 |
2001年 | 190篇 |
2000年 | 135篇 |
1999年 | 231篇 |
1998年 | 284篇 |
1997年 | 219篇 |
1996年 | 208篇 |
1995年 | 195篇 |
1994年 | 172篇 |
1993年 | 147篇 |
1992年 | 196篇 |
1991年 | 146篇 |
1990年 | 120篇 |
1989年 | 132篇 |
1988年 | 116篇 |
1987年 | 110篇 |
1986年 | 100篇 |
1985年 | 132篇 |
1984年 | 140篇 |
1983年 | 113篇 |
1982年 | 157篇 |
1981年 | 168篇 |
1980年 | 134篇 |
1979年 | 129篇 |
1978年 | 125篇 |
1977年 | 113篇 |
1976年 | 119篇 |
1975年 | 76篇 |
1974年 | 90篇 |
1973年 | 85篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
23.
24.
25.
26.
Véronique Lavoie Anne‐Elen Kernaleguen Guy Charron Nada Farhat Mariève Cossette Aida M. Mamarbachi Bruce G. Allen Eric Rhéaume Jean‐Claude Tardif 《Obesity (Silver Spring, Md.)》2011,19(4):722-728
Adiponectin is an adipokine whose plasma levels are inversely correlated to metabolic syndrome components. Adiponectin protects against atherosclerosis and decreases risks in myocardial infarction. Endothelial progenitor cells (EPCs) are a heterogeneous population of circulating cells involved in vascular repair and neovascularization. EPCs number is reduced in patients with cardiovascular disease. We hypothesize that the positive effects of adiponectin against atherosclerosis are explained in part by its interactions with EPCs. Cells were obtained from healthy volunteers' blood by mononuclear cell isolation and plating on collagen‐coated dishes. Three sub‐populations of EPCs were identified and characterized using flow cytometry. EPCs' expression of adiponectin receptors, AdipoR1, and AdipoR2 was evaluated by quantitative PCR. The effects of recombinant adiponectin on EPCs' susceptibility to apoptosis were assessed. Finally, expression of neutrophil elastase by EPCs and activity of this enzyme on adiponectin processing were assessed. Quantitative PCR analysis of EPCs mRNAs showed that AdipoR1 mRNA is expressed at higher levels than AdipoR2. Expression of AdipoR1 protein was confirmed by western blot. Adiponectin significantly increased survival of two sub‐populations of EPCs in conditions of serum deprivation. Such effect could not be demonstrated in the third EPCs sub‐population. We also demonstrated that EPCs, particularly one sub‐population, express neutrophil elastase. Neutrophil elastase activity was confirmed in EPCs' conditioned media. Adiponectin protects some EPCs sub‐populations against apoptosis and therefore could modulate EPCs ability to induce repair of vascular damage. Neutrophil elastase activity of EPCs could locally modulate adiponectin activity by its involvement in the generation of the globular form of adiponectin. 相似文献
27.
Effects of applications of municipal compost on uptake of copper,zinc and boron by garden vegetables
Summary Municipal compost applied to soils in plot experiments with cabbages, lettuces, beans, potatoes and peas in three successive years (25–100 tonnes per hectare) has produced significant enhancement of available soil Cu, Zn and B in each year. Associated significant increases in uptake were as follows: Cu, Zn and B with lettuces and beans, Zn and B with potatoes and B with peas. No significant increases in uptake of any of these elements was obtained in two experiments with cabbages.Compost treatment was associated with severe phytotoxic effects in the experiment with beans and with yield responses in the experiments with peas and potatoes. re]19721116 相似文献
28.
Jean L. Santos Paulo R. Yamasaki Chung Man Chin Célio H. Takashi Fernando R. Pavan Clarice Q.F. Leite 《Bioorganic & medicinal chemistry》2009,17(11):3795-3799
New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70–90%). All compounds (3a–l) were evaluated against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 μg/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis. 相似文献
29.
Nicolas Lamassiaude Berthine Toubate Cdric Neveu Pierre Charnet Catherine Dupuy Franoise Debierre-Grockiego Isabelle Dimier-Poisson Claude L. Charvet 《PLoS pathogens》2021,17(2)
Control of infestation by cosmopolitan lice (Pediculus humanus) is increasingly difficult due to the transmission of parasites resistant to pediculicides. However, since the targets for pediculicides have no been identified in human lice so far, their mechanisms of action remain largely unknown. The macrocyclic lactone ivermectin is active against a broad range of insects including human lice. Isoxazolines are a new chemical class exhibiting a strong insecticidal potential. They preferentially act on the γ-aminobutyric acid (GABA) receptor made of the resistant to dieldrin (RDL) subunit and, to a lesser extent on glutamate-gated chloride channels (GluCls) in some species. Here, we addressed the pediculicidal potential of isoxazolines and deciphered the molecular targets of ivermectin and the ectoparasiticide lotilaner in the human body louse species Pediculus humanus humanus. Using toxicity bioassays, we showed that fipronil, ivermectin and lotilaner are efficient pediculicides on adult lice. The RDL (Phh-RDL) and GluCl (Phh-GluCl) subunits were cloned and characterized by two-electrode voltage clamp electrophysiology in Xenopus laevis oocytes. Phh-RDL and Phh-GluCl formed functional homomeric receptors respectively gated by GABA and L-glutamate with EC50 values of 16.0 μM and 9.3 μM. Importantly, ivermectin displayed a super agonist action on Phh-GluCl, whereas Phh-RDL receptors were weakly affected. Reversally, lotilaner strongly inhibited the GABA-evoked currents in Phh-RDL with an IC50 value of 40.7 nM, whereas it had no effect on Phh-GluCl. We report here for the first time the insecticidal activity of isoxazolines on human ectoparasites and reveal the mode of action of ivermectin and lotilaner on GluCl and RDL channels from human lice. These results emphasize an expected extension of the use of the isoxazoline drug class as new pediculicidal agents to tackle resistant-louse infestations in humans. 相似文献
30.
Loïc Pellissier Charlotte Ndiribe Anne Dubuis Jean‐Nicolas Pradervand Nicolas Salamin Antoine Guisan Sergio Rasmann 《Ecology letters》2013,16(5):600-608
Understanding drivers of biodiversity patterns is of prime importance in this era of severe environmental crisis. More diverse plant communities have been postulated to represent a larger functional trait‐space, more likely to sustain a diverse assembly of herbivore species. Here, we expand this hypothesis to integrate environmental, functional and phylogenetic variation of plant communities as factors explaining the diversity of lepidopteran assemblages along elevation gradients in the Swiss Western Alps. According to expectations, we found that the association between butterflies and their host plants is highly phylogenetically structured. Multiple regression analyses showed the combined effect of climate, functional traits and phylogenetic diversity in structuring butterfly communities. Furthermore, we provide the first evidence that plant phylogenetic beta diversity is the major driver explaining butterfly phylogenetic beta diversity. Along ecological gradients, the bottom up control of herbivore diversity is thus driven by phylogenetically structured turnover of plant traits as well as environmental variables. 相似文献