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551.
Karthick Dharmalingam Velvizhi Dharmalingam Satheesh Durairaj Praveen Sharma Selvaraj Jayaraman 《Bioinformation》2021,17(11):924
It is of interest to document the molecular docking analysis data of penta-galloyl-glucose with VEGF signaling molecules in the context of cancer. Data shows that penta-galloyl-glucose have optimal binding affinities with VEGF-A,VEGFR-2, PKC, RAF, MEK, ERK and AKT with binding affinity of -7.9,-8.3,-8.6, -3.7,10.1,-9 and -10.8 kcal/mol respectively for further consideration in this context. 相似文献
552.
Ponnulakshmi Rajagopal Selvaraj Jayaraman Shazia Fathima JH Saravanan Radhakrishnan Patil Ashlesh Laxman Vijaya Prakash Krishnan Muthaiah Satyendra Chandra Tripathi TS Gugapriya Aaditya Madhusudan Tarnekar Gayatri Girish Muthiyan Vishwajit Ravindra Deshmukh Bharat Ramrao Sontakke Kirubhanand Chandrashekar 《Bioinformation》2021,17(11):928
553.
S Saleem Basha Dhirendra Tripathi Sravanthi Koora K Satyanarayana Selvaraj Jayaraman 《Bioinformation》2021,17(5):568
The use of "kabasura kudineer" (liquid soup made from Indian medicinal plants) for combating COVID-19 has been common in the states of Tamilnadu and Puducherry, India during the pandemic. Therefore, it is of interest to document the molecular docking analysis of IL-6 inhibitors with potential antiviral compounds from "kabasura kudineer" extract. We show the optimal binding features of gallic acid and luteolin with the Interleukin-6 protein for further consideration. 相似文献
554.
The interaction between the third-order T suppressor (Ts3) cell and the idiotype (Id)-specific second-order Ts factor (TsF2) was studied in the phenyltrimethylamino (TMA) hapten system. The experimental system which we used allowed the independent analysis of induction and activation requirements of Ts3. The procedure consisted of inducing the Ts3 in vivo and activating the enriched T-cell populations containing Ts3 in vitro with TsF2. The suppressive potential was then tested in mice previously primed for delayed-type hypersensitivity responses which were also treated with cyclophosphamide to deplete Ts3 and other drug-sensitive Ts cell types. Using this experimental system, it was found that the Id-specific TsF2 was required for the in vitro activation of Ts3. Furthermore, the TsF2 activated only the homologous and not heterologous antigen-primed Ts3-containing T cells and moreover, the target of TsF2 was found to be the Ts cells bearing hapten-specific receptors. Once the TMA hapten-specific Ts3 was activated with TsF2, the ensuing suppression was antigen nonspecific. The data demonstrate that the Ts3 represents a final effector Ts cell type in the TMA system. 相似文献
555.
Arif mutantof Escherichia coli that exhibits medium and temperature-dependent sensitivity to rifampicin is described. In the absence of rifampicin, this strain grows in minimal and rich media at 30°C and 42°C. In its presence it is viable in rich medium at both temperatures, but in minimal medium only at 30°C. In minimal-rifampicin medium at the higher temperature, RNA synthesis is decreased. The addition of certain divalent salts (MgSO4, CaCl2, BaCl2) in excess, or chelators (EDTA, EGTA, o-phenanthrolein) greatly increase viability in minimal-rifampicin medium at 42°C. Excess MgSO4 (10 mM) also increases the rate of RNA synthesis in the same medium. A model is proposed wherein therif mutation is suggested to cause a structural change in RNA polymerase that allows the binding of rifampicin and other ligands at 42°C. Rifampicin-binding is suggested to alter the conformation of RNA polymerase, impairing its ability to express genes required for growth in minimal medium. Implicit in this view is the assumption that these genes are structurally different from those expressed in rich medium in respect of certain template features recognized by RNA polymerase. 相似文献
556.
Exposure of freshwater fish to saline conditions brings about somewhat drastic changes in the mitochondrial energy metabolism. These include abolition of oxidative phosphorylation, ATP-induced contraction of swollen mitochondria and transhydrogenase activity. On the other hand the endogenous calcium levels and protein synthetic capacity are elevated. In vitro protein synthesis by mitochondria from freshwater and stressed fish shows qualitative and quantitative variations. Effluxing the excess calcium by treatment with NaCl or inhibiting the protein synthesis by chloramphenicol in stressed mitochondria restores almost all the functions. It is proposed that the energy potential formed by the mitochondrial membrane is channelized to perform different functions and that the ratio of channelization can be altered to suit the needs of the cell. 相似文献
557.
Importance of biofilm formation for corrosion inhibition of SAE 1018 steel by axenic aerobic biofilms 总被引:1,自引:0,他引:1
A Jayaraman E T Cheng J C Earthman T K Wood 《Journal of industrial microbiology & biotechnology》1997,18(6):396-401
To investigate if corrosion inhibition by aerobic biofilms is a general phenomenon, carbon steel (SAE 1018) coupons were
exposed to a complex liquid medium (Luria–Bertani) and seawater-mimicking medium (VNSS) containing fifteen different pure-culture
bacterial suspensions representing seven genera. Compared to sterile controls, the mass loss in the presence of these bacteria
(which are capable of developing a biofilm to various degrees) decreased by 2- to 15-fold. The extent of corrosion inhibition
in LB medium depended on the nature of the biofilm: an increased proportion of live cells, observed with confocal scanning
laser microscopy (CSLM) and image analysis, decreased corrosion. Corrosion inhibition in LB medium was greatest with Pseudomonas putida (good biofilm formation), while metal coupons exposed to Streptomyces lividans in LB medium (poor biofilm formation) corroded in a manner similar to the sterile controls. Pseudomonas mendocina KR1 reduced corrosion the most in VNSS. It appears that only a small layer of active, respiring cells is required to inhibit
corrosion, and the corrosion inhibition observed is due to the attached biofilm.
Received 09 December 1996/ Accepted in revised form 19 March 1997 相似文献
558.
L J Ko S Y Shieh X Chen L Jayaraman K Tamai Y Taya C Prives Z Q Pan 《Molecular and cellular biology》1997,17(12):7220-7229
559.
560.